Journal article
Control of oxygen free radical formation from mitochondrial complex I: roles for protein kinase A and pyruvate dehydrogenase kinase
Abstract
Human NADH CoQ oxidoreductase is composed of a total of 43 subunits and has been demonstrated to be a major site for the production of superoxide by mitochondria. Incubation of rat heart mitochondria with ATP resulted in the phosphorylation of two mitochondrial membrane proteins, one with a M(r) of 6 kDa consistent with the NDUFA1 (MWFE), and one at 18kDa consistent with either NDUFS4 (AQDQ) or NDUFB7 (B18). Phosphorylation of both subunits was …
Authors
Raha S; Myint AT; Johnstone L; Robinson BH
Journal
Free Radical Biology and Medicine, Vol. 32, No. 5, pp. 421–430
Publisher
Elsevier
Publication Date
March 2002
DOI
10.1016/s0891-5849(01)00816-4
ISSN
0891-5849
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adenosine TriphosphateAnimalsBlotting, WesternCyclic AMPCyclic AMP-Dependent Protein KinasesElectron Transport Complex IEnzyme ActivationFirefly LuciferinHumansImidazolesMembrane ProteinsMitochondria, HeartNADNADH DehydrogenaseNADH, NADPH OxidoreductasesOxygen ConsumptionPhosphorylationProtein Kinase InhibitorsProtein KinasesProtein Serine-Threonine KinasesPyrazinesPyruvate Dehydrogenase Acetyl-Transferring KinaseRatsRats, WistarReactive Oxygen SpeciesSuperoxides