Journal article
Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo
Abstract
Background:Evidence suggests that dysregulation of energy-sensing pathways closely associates with renal cell carcinoma (RCC) development. The metabolic regulation is largely controlled by 5′-AMP activated protein kinase (AMPK) which is activated through phosphorylation by LKB1.Methods:The expression of LKB1 was determined by reverse transcription–PCR using 10 clinical clear cell RCC (ccRCC) samples and their adjacent normal renal parenchyma, …
Authors
Duivenvoorden WC; Beatty LK; Lhotak S; Hill B; Mak I; Paulin G; Gallino D; Popovic S; Austin RC; Pinthus JH
Journal
British Journal of Cancer, Vol. 108, No. 2, pp. 327–333
Publisher
Springer Nature
Publication Date
2 2013
DOI
10.1038/bjc.2012.574
ISSN
0007-0920
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesAnimalsCarcinoma, Renal CellCell Line, TumorCell ProliferationHumansKidney NeoplasmsMaleMiceMice, Inbred BALB CMice, NudeNeoplasm InvasivenessPhosphorylationProtein Serine-Threonine KinasesRNA InterferenceRNA, Small InterferingSignal TransductionTransplantation, HeterologousVascular Endothelial Growth Factor A