Journal article
YAP1 Meets Tumor Suppression
Abstract
In this issue of Molecular Cell, Matallanas et al. (2007) demonstrate that RASSF1A-induced apoptosis impinges on the transcriptional coactivator YAP1, whose nuclear translocation and binding to p73 result in proper execution of the cell death pathway. Indeed, RASSF1A silencing in tumors inhibits YAP1-p73-dependent apoptosis.
Authors
Strano S; Blandino G
Journal
Molecular Cell, Vol. 27, No. 6, pp. 863–864
Publisher
Elsevier
Publication Date
September 2007
DOI
10.1016/j.molcel.2007.09.004
ISSN
1097-2765
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Adaptor Proteins, Signal TransducingApoptosisDNA-Binding ProteinsHumansNuclear ProteinsPhosphoproteinsProtein BindingProtein Serine-Threonine KinasesProto-Oncogene Proteins c-rafSerine-Threonine Kinase 3Transcription FactorsTranscription, GeneticTumor Protein p73Tumor Suppressor Protein p53Tumor Suppressor ProteinsYAP-Signaling Proteins