Journal article
Excitation-contraction coupling in pulmonary vascular smooth muscle involves tyrosine kinase and Rho kinase
Abstract
We investigated the mechanisms that underlie the responses to norepinephrine (NE) and thromboxane (Tx) A(2) (TxA2) in the canine pulmonary vasculature with fura 2 fluorimetric, intracellular microelectrode, and force transduction techniques. KCl, caffeine, and cyclopiazonic acid elevated intracellular Ca2+ concentration levels and tone, indicating that Ca2+ mobilization is sufficient to produce contraction. However, contractions evoked by NE or …
Authors
Janssen LJ; Lu-Chao H; Netherton S
Journal
American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 280, No. 4, pp. l666–l674
Publisher
American Physiological Society
Publication Date
April 1, 2001
DOI
10.1152/ajplung.2001.280.4.l666
ISSN
1040-0605
Fields of Research (FoR)
Medical Subject Headings (MeSH)
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic AcidAnimalsCaffeineCalciumDogsElectrophysiologyIn Vitro TechniquesIndolesIntracellular Signaling Peptides and ProteinsMuscle, Smooth, VascularNorepinephrineProtein Serine-Threonine KinasesProtein-Tyrosine KinasesPulmonary CirculationVasoconstrictionVasoconstrictor Agentsrho-Associated Kinases