Journal article
ATM activity contributes to the tumor-suppressing functions of p14ARF
Abstract
P14/p19ARF (ARF) plays a major role in the activation of p53 by oncogenic signals. The biochemical basis of this has not been fully elucidated. We report here that forced expression of p14ARF enhances phosphorylation of p53 serine 15 (p53S15) in NIH3T3, IMR90 and MCF7 cells. Ectopic expression of the oncogenes c-myc, E2F1 and E1A, all of which activate p53 at least partially via ARF, lead to p53S15 phosphorylation in IMR90 cells. In addition, …
Authors
Li Y; Wu D; Chen B; Ingram A; He L; Liu L; Zhu D; Kapoor A; Tang D
Journal
Oncogene, Vol. 23, No. 44, pp. 7355–7365
Publisher
Springer Nature
Publication Date
September 23, 2004
DOI
10.1038/sj.onc.1207957
ISSN
0950-9232
Fields of Research (FoR)
Medical Subject Headings (MeSH)
3T3 CellsAnimalsAtaxia TelangiectasiaAtaxia Telangiectasia Mutated ProteinsBase SequenceCell Cycle ProteinsCell DivisionCell Line, TumorDNA-Binding ProteinsGenes, mycHumansMiceMolecular Sequence DataPhosphorylationProtein Serine-Threonine KinasesRNA, AntisenseRNA, Small InterferingRecombinant ProteinsReverse Transcriptase Polymerase Chain ReactionTransfectionTumor Suppressor Protein p14ARFTumor Suppressor Protein p53Tumor Suppressor Proteins