Gene Deletion Concept

subject area of

• A Reliable Screening Test to Identify Adult Carriers of the (--SEA) alpha0-Thalassemia Deletion  Academic Article
• A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism  Academic Article
• A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium  Academic Article
• A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria  Academic Article
• A novel compound heterozygous mutation of the luteinizing hormone receptor –implications for fertility  Academic Article
• A novel nucleoid-associated protein specific to the actinobacteria  Academic Article
• A robust platform for chemical genomics in bacterial systems  Academic Article
• AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance  Academic Article
• AMPK β1 reduces tumor progression and improves survival in p53 null mice  Academic Article
• ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes  Academic Article
• ATM whole gene deletion in an Italian family with hereditary pancreatic cancer: Challenges to cancer risk prediction associated with an 11q22.3 microdeletion  Academic Article
• Absence of a Paternally Inherited FOXP2 Gene in Developmental Verbal Dyspraxia  Academic Article
• Aggregation via the Red, Dry, and Rough Morphotype Is Not a Virulence Adaptation in Salmonella enterica Serovar Typhimurium  Academic Article
• Antagonistic regulation of motility and transcriptome expression by RpoN and RpoS in Escherichia coli  Academic Article
• Anti-ζ Antibody Screening for α-Thalassemia Using Dried Filter Paper Blood  Academic Article
• Apoptotic Cell Death in Mouse Models of GM2 Gangliosidosis and Observations on Human Tay-Sachs and Sandhoff Diseases  Academic Article
• Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein  Academic Article
• Atypical clinical course in juvenile metachromatic leukodystrophy involving novel arylsulfatase A gene mutations  Academic Article
• BMP Receptor ALK3 Controls Collecting System Development  Academic Article
• Bacteria Getting into Shape: Genetic Determinants of E. coli Morphology  Academic Article
• BldD fromStreptomyces coelicoloris a non-essential global regulator that binds its own promoter as a dimer  Academic Article
• CYFIP/Sra-1 Controls Neuronal Connectivity in Drosophila and Links the Rac1 GTPase Pathway to the Fragile X Protein  Academic Article
• Characterisation of a novel 49�3�kbG?(A???)0-thalassaemia deletion in seven families of Asian descent  Academic Article
• Characterisation of the British α0-thalassaemia deletion: evidence of a founder effect in Newfoundland, Canada  Academic Article
• Characterization of a Rare Single α-Globin Gene Deletion in a Chinese Woman with Hb H Disease  Academic Article
• Characterization of a lymphoblastoid line deleted for lambda immunoglobulin genes  Academic Article
• Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance  Academic Article
• Characterization of nickel-induced mutations  Academic Article
• Characterization of the Depletion of 2-C-Methyl-d-Erythritol-2,4-Cyclodiphosphate Synthase in Escherichia coli and Bacillus subtilis  Academic Article
• Chlamydiae-specific proteins and indels: novel tools for studies  Academic Article
• Clinical course and molecular characterization of a compound heterozygote for sickle hemoglobin and hemoglobin kenya  Academic Article
• Clinical, enzymatic and molecular characterization of nine new patients with malonyl-coenzyme A decarboxylase deficiency  Academic Article
• Complementation of growth defect in anampCdeletion mutant ofEscherichia coli  Academic Article
• Conditional Deletion of Activating Protein 2α (AP-2α) in the Developing Retina Demonstrates Non-Cell-Autonomous Roles for AP-2α in Optic Cup Development  Academic Article
• Conditional deletion of AP-2β in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma  Academic Article
• Conserved indels in essential proteins that are distinctive characteristics of Chlamydiales and provide novel means for their identification  Academic Article
• Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell–dependent B cell responses  Academic Article
• Crp Is a Global Regulator of Antibiotic Production in Streptomyces  Academic Article
• Deleting Rac1 improves vertebral bone quality and resistance to fracture in a murine ovariectomy model  Academic Article
• Deletion of GSK-3β in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation  Academic Article
• Detection of the (–SEA) double α-globin gene deletion by a simple immunologic assay for embryonic ζ-globin chains  Academic Article
• Development of Cell Lines Capable of Complementing E1, E4, and Protein IX Defective Adenovirus Type 5 Mutants  Academic Article
• Development of a size-restricted pIX-deleted helper virus for amplification of helper-dependent adenovirus vectors  Academic Article
• Development, Antibiotic Production, and Ribosome Assembly in Streptomyces venezuelae Are Impacted by RNase J and RNase III Deletion  Academic Article
• Diagnostic testing for α-globin gene disorders in a heterogeneous North American population  Academic Article
• Disruption of M-T5, a novel myxoma virus gene member of poxvirus host range superfamily, results in dramatic attenuation of myxomatosis in infected European rabbits.  Academic Article
• Dual amyloid domains promote differential functioning of the chaplin proteins during Streptomyces aerial morphogenesis  Academic Article
• Duplication of Teichoic Acid Biosynthetic Genes in Staphylococcus aureus Leads to Functionally Redundant Poly(Ribitol Phosphate) Polymerases  Academic Article
• ERM is required for transcriptional control of the spermatogonial stem cell niche  Academic Article
• Estimating the Frequency of Horizontal Gene Transfer Using Phylogenetic Models of Gene Gain and Loss  Academic Article
• Evidence that Herpes Simplex Virus VP16 Is Required for Viral Egress Downstream of the Initial Envelopment Event  Academic Article
• Evolution of Proteasome Regulators in Eukaryotes  Academic Article
• Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase fromPlasmodium falciparum  Academic Article
• Extending knowledge on inherited platelet disorders associated with thrombocytopenia  Academic Article
• Fetal hemoglobin in sickle cell anemia: a glass half full?  Academic Article
• From p63 to p53 across p73  Academic Article
• GUTI: a new antigen in the Cromer blood group system  Academic Article
• Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3  Academic Article
• Genetic Interaction Screens with Ordered Overexpression and Deletion Clone Sets Implicate the Escherichia coli GTPase YjeQ in Late Ribosome Biogenesis  Academic Article
• Genomic and Genic Deletions of the FOX Gene Cluster on 16q24.1 and Inactivating Mutations of FOXF1 Cause Alveolar Capillary Dysplasia and Other Malformations  Academic Article
• Genomic organization and linkage via a bidirectional promoter of the AP-3 (adaptor protein-3) mu3A and AK (adenosine kinase) genes: deletion mutants of AK in Chinese hamster cells extend into the AP-3 mu3A gene  Academic Article
• Gigantic splenomegaly in a 27-year-old male of South-East Asian descent with concurrent diagnosis of myeloproliferative neoplasm and hemoglobin H disease  Academic Article
• Glucosamine-Induced Endoplasmic Reticulum Dysfunction Is Associated With Accelerated Atherosclerosis in a Hyperglycemic Mouse Model  Academic Article
• HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data  Academic Article
• Hb Adana (HBA2 or HBA1: c.179G > A) and alpha thalassemia: Genotype-phenotype correlation  Academic Article
• Hb H hydrops foetalis syndrome: a case report and review of literature  Academic Article
• Hemoglobin H (Hb H) disease in Canada: Molecular diagnosis and review of 116 cases  Academic Article
• Heterophilic Binding of L1 on Unmyelinated Sensory Axons Mediates Schwann Cell Adhesion and Is Required for Axonal Survival  Academic Article
• High rates of lateral gene transfer are not due to false diagnosis of gene absence  Academic Article
• Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy  Academic Article
• Host Defense Peptide Resistance Contributes to Colonization and Maximal Intestinal Pathology by Crohn's Disease-Associated Adherent-Invasive Escherichia coli  Academic Article
• Identification of two novel β°-thalassemia mutations in a filipino family: Frameshift codon 67 (− TG) and a β-globin gene deletion  Academic Article
• Inactivation of MuxABC-OpmB transporter system in Pseudomonas aeruginosa leads to increased ampicillin and carbenicillin resistance and decreased virulence  Academic Article
• Infantile metachromatic leukodystrophy (MLD) in a compound heterozygote for the c.459 + 1G > A mutation and a complete deletion of theARSA gene  Academic Article
• Inferring Bacterial Genome Flux While Considering Truncated Genes  Academic Article
• Interphase FISH analysis of PTEN in histologic sections shows genomic deletions in 68% of primary prostate cancer and 23% of high-grade prostatic intra-epithelial neoplasias  Academic Article
• Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome  Academic Article
• Known Bioactive Small Molecules Probe the Function of a Widely Conserved but Enigmatic Bacterial ATPase, YjeE  Academic Article
• Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function  Academic Article
• Lentiviral vectors pseudotyped with minimal filovirus envelopes increased gene transfer in murine lung  Academic Article
• Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity1  Academic Article
• Loss of Hepatocyte-Nuclear-Factor-1α Impacts on Adult Mouse Intestinal Epithelial Cell Growth and Cell Lineages Differentiation  Academic Article
• Loss of Hepatocyte-Nuclear-Factor-4α Affects Colonic Ion Transport and Causes Chronic Inflammation Resembling Inflammatory Bowel Disease in Mice  Academic Article
• Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα  Academic Article
• Menin Links the Stress Response to Genome Stability in Drosophila melanogaster  Academic Article
• Metabolic modelling reveals the specialization of secondary replicons for niche adaptation in Sinorhizobium meliloti  Academic Article
• Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation  Academic Article
• Microdeletion in distal 17p13.1: A recognizable phenotype with microcephaly, distinctive facial features, and intellectual disability  Academic Article
• Modulation of Hexa-Acyl Pyrophosphate Lipid A Population under Escherichia coli Phosphate (Pho) Regulon Activation  Academic Article
• Mouse models for mitochondrial disease  Academic Article
• Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma  Academic Article
• Novel 27.9 kb α0-thalassemia deletion in a Filipino woman  Academic Article
• Novel Repressor of Escherichia coli O157:H7 Motility Encoded in the Putative Fimbrial Cluster OI-1  Academic Article
• Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure  Academic Article
• Novel seventeen basepair deletion in exon 3 of the β-globin gene  Academic Article
• OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome  Academic Article
• Oxidative stress and the mitochondrial theory of aging in human skeletal muscle  Academic Article
• PCR-based diagnosis of the Filipino (??FIL) and Thai (??THAI) ?-thalassemia-1 deletions  Academic Article
• Packaging capacity and stability of human adenovirus type 5 vectors.  Academic Article
• Parents of children with spinal muscular atrophy are not obligate carriers: Carrier testing is important for reproductive decision-making  Academic Article
• Phenotypic spectrum associated with de novo and inherited deletions and duplications at 16p11.2 in individuals ascertained for diagnosis of autism spectrum disorder  Academic Article
• PhoU Allows Rapid Adaptation to High Phosphate Concentrations by Modulating PstSCAB Transport Rate in Sinorhizobium meliloti  Academic Article
• Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among Diverse Processes in Bacterial Cell Wall Biogenesis  Academic Article
• Production and Characterization of Monoclonal Antibodies to ARVCF  Academic Article
• Production and characterization of human 293 cell lines expressing the site-specific recombinase Cre  Academic Article
• Protein signatures distinctive of chlamydial species: horizontal transfers of cell wall biosynthesis genes glmU from archaea to chlamydiae and murA between chlamydiae and Streptomyces a aThe GenBank accession numbers for the sequences reported in this paper are indicated in the text.  Academic Article
• Pseudomonas aeruginosa Minor Pilins Are Incorporated into Type IV Pili  Academic Article
• Quantification of mitochondrial sublimons in human fibrillating atria  Academic Article
• Rare Deletions at the Neurexin 3 Locus in Autism Spectrum Disorder  Academic Article
• Regulation of Gastric Acid Secretion by PKB/Akt2  Academic Article
• Resistance exercise training decreases oxidative damage to DNA and increases cytochrome oxidase activity in older adults  Academic Article
• Ribosome biogenesis; the KsgA protein throws a methyl-mediated switch in ribosome assembly  Academic Article
• Role for Retinoblastoma Protein Family Members in UV-enhanced Expression from the Human Cytomegalovirus Immediate Early Promoter¶  Academic Article
• Salmonella Evades d-Amino Acid Oxidase To Promote Infection in Neutrophils  Academic Article
• Salmonella enterica Serovar Senftenberg Human Clinical Isolates Lacking SPI-1  Academic Article
• SapB and the chaplins: connections between morphogenetic proteins in Streptomyces coelicolor  Academic Article
• Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen  Academic Article
• Severe fetal and neonatal hemolytic anemia due to a 198 kb deletion removing the complete β-globin gene cluster  Academic Article
• Sickle cell disease due to compound heterozygosity for Hb S and a novel 7.7-kb ?-globin gene deletion  Academic Article
• Single-Tube Multiplex-PCR Screen for Anti-3.7 and Anti-4.2 α-Globin Gene Triplications  Academic Article
• SmeA, a small membrane protein with multiple functions in Streptomyces sporulation including targeting of a SpoIIIE/FtsK-like protein to cell division septa  Academic Article
• SseL Is a Salmonella-Specific Translocated Effector Integrated into the SsrB-Controlled Salmonella Pathogenicity Island 2 Type III Secretion System  Academic Article
• Stromally Expressed β-Catenin Modulates Wnt9b Signaling in the Ureteric Epithelium  Academic Article
• Targeted Deletion ofAP-2α Leads to Disruption in Corneal Epithelial Cell Integrity and Defects in the Corneal Stroma  Academic Article
• Targeted Deletion offgl2Leads to Impaired Regulatory T Cell Activity and Development of Autoimmune Glomerulonephritis  Academic Article
• Targeted Mutagenesis of Burkholderia thailandensis and Burkholderia pseudomallei through Natural Transformation of PCR Fragments  Academic Article
• The ATPase activity of an ‘essential’ Bacillus subtilis enzyme, YdiB, is required for its cellular function and is modulated by oligomerization  Academic Article
• The Genome-Wide Interaction Network of Nutrient Stress Genes inEscherichia coli  Academic Article
• The Helicobacter pyloricell shape promoting protein Csd5 interacts with the cell wall, MurF, and the bacterial cytoskeleton  Academic Article
• The Ocular Manifestations of Jacobsen Syndrome: A Report of Four Cases and a Review of the Literature  Academic Article
• The Pleckstrin homology like domain family member, TDAG51, is temporally regulated during skeletal muscle regeneration  Academic Article
• The SseC translocon component in Salmonella enterica serovar Typhimurium is chaperoned by SscA  Academic Article
• The advantages and disadvantages of horizontal gene transfer and the emergence of the first species  Academic Article
• The attenuated virulence of aBurkholderia cenocepacia paaABCDEmutant is due to inhibition of quorum sensing by release of phenylacetic acid  Academic Article
• The expanding clinical phenotype of Bosch-Boonstra-Schaaf optic atrophy syndrome: 20 new cases and possible genotype–phenotype correlations  Academic Article
• The gene cluster for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230 includes novel shikimate pathway homologues and a monomodular non-ribosomal peptide synthetase gene The GenBank accession number for the sequence reported in this paper is AF262220.  Academic Article
• The gut microbiome regulates host glucose homeostasis via peripheral serotonin  Academic Article
• The pdx genetic marker adjacent to the chloramphenicol biosynthesis gene cluster in Streptomyces venezuelae ISP5230: functional characterization The GenBank accession number for the sequence reported in this paper is AF286159.  Academic Article
• The phylogeny of proteobacteria: relationships to other eubacterial phyla and eukaryotes  Academic Article
• The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults  Academic Article
• The role of laterally transferred genes in adaptive evolution  Academic Article
• The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation  Academic Article
• The tRNAargGene andengAAre Essential Genes on the 1.7-Mb pSymB Megaplasmid of Sinorhizobium meliloti and Were Translocated Together from the Chromosome in an Ancestral Strain  Academic Article
• The yjeQ Gene Is Required for Virulence of Staphylococcus aureus  Academic Article
• Tissue-Specific Role of Glycogen Synthase Kinase 3β in Glucose Homeostasis and Insulin Action  Academic Article
• Trichlorination of a Teicoplanin-Type Glycopeptide Antibiotic by the Halogenase StaI Evades Resistance  Academic Article
• Uncovering rate variation of lateral gene transfer during bacterial genome evolution  Academic Article
• Understanding ribosome assembly: the structure of in vivo assembled immature 30S subunits revealed by cryo-electron microscopy  Academic Article
• Using G-deleted vesicular stomatitis virus to probe the innate anti-viral response  Academic Article
• Wall Teichoic Acid Polymers Are Dispensable for Cell Viability in Bacillus subtilis  Academic Article
• Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity  Academic Article
• ets‐1 is transcriptionally up‐regulated by H 2 O 2 via an antioxidant response element  Academic Article
• p14ARF inhibits the growth of p53 deficient cells in a cell-specific manner  Academic Article
• β-thalassemia intermedia due to compound heterozygosity for two β-globin gene promoter mutations, including a novel TATA box deletion  Academic Article