The sonic hedgehog factor GLI1 imparts drug...

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation

Abstract

A new mechanism by which acute myeloid leukaemia patients become resistant to Ara-C and a newer treatment, ribavirin, is uncovered; these drugs can be glucuronidated and thereby inactivated by members of the UDP glucuronosyltransferase family of enzymes activated through GLI1 signalling.

Authors

Zahreddine HA; Culjkovic-Kraljacic B; Assouline S; Gendron P; Romeo AA; Morris SJ; Cormack G; Jaquith JB; Cerchietti L; Cocolakis E

Journal

Nature, Vol. 511, No. 7507, pp. 90–93

Publisher

Springer Nature

Publication Date

July 3, 2014

DOI

10.1038/nature13283

ISSN

0028-0836

Associated Experts

Brian Leber

Professor Emeritus, Faculty of Health Sciences

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