Gene products required for in vivo growth and survival of
Staphylococcus aureusand other pathogens represent new targets for antimicrobial chemotherapy. In this study we created a Staphylococcus aureus yjeQdeletion strain and tested its virulence using a mouse kidney abscess infection model. The yjeQdeletion strain was compromised for growth in vitro and severely attenuated for virulence. We concluded that yjeQis an attractive and novel new drug target.