Journal article
Known Bioactive Small Molecules Probe the Function of a Widely Conserved but Enigmatic Bacterial ATPase, YjeE
Abstract
Escherichia coli YjeE is a broadly conserved bacterial ATPase of unknown function that has been widely characterized as essential. Here, the transcriptional regulation of the promoter of yjeE (P(yjeE)) was probed using a luciferase reporter and 172 antibiotics of diverse mechanisms. Norfloxacin and other fluorquinolones were found to be the most potent activator of P(yjeE) through binding to DNA gyrase. The stimulation of P(yjeE) by norfloxacin …
Authors
Mangat CS; Brown ED
Journal
Cell Chemical Biology, Vol. 15, No. 12, pp. 1287–1295
Publisher
Elsevier
Publication Date
December 2008
DOI
10.1016/j.chembiol.2008.10.007
ISSN
2451-9456