BldD fromStreptomyces coelicoloris a non-essential global regulator that binds its own promoter as a dimer Academic Article uri icon

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abstract

  • We have shown that the bldD gene of Streptomyces coelicolor, while required for antibiotic production and morphological differentiation, is not essential for viability. We have also demonstrated that BldD forms a higher order complex both in solution and when bound to target DNA. Purified BldD exists in three forms in solution, as a tetramer, dimer and monomer, but only in the dimeric form when bound to its own promoter/operator.

authors

  • Elliot, Marie
  • Locke, Troy R
  • Galibois, Claire M
  • Leskiw, Brenda K

publication date

  • August 2003