Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell–dependent B cell responses Academic Article uri icon

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abstract

  • Costimulation through the inducible costimulator (ICOS) and its ligand (ICOSL) is essential for T cell-dependent B cell responses, but the cellular and temporal dynamics underlying its in vivo effects are poorly defined. Here we have shown that Icosl(-/-) and Icos(-/-) mice had similar phenotypes and that ICOS-ICOSL costimulation modulated the early but not late phases of IgG1 affinity maturation. Exploiting the adoptive transfer of T or B cells from primed Icosl(-/-) mice, we provided genetic evidence that costimulation through ICOSL was essential for primary but not secondary helper T cell responses and for the control of both T and B cell activities, resulting in T cell-dependent IgG1 production.

authors

  • Mak, Tak W
  • Shahinian, Arda
  • Yoshinaga, Steve K
  • Wakeham, Andrew
  • Boucher, Louis-Martin
  • Pintilie, Melania
  • Duncan, Gordon
  • Gajewska, Beata U
  • Gronski, Matthew
  • Eriksson, Urs
  • Odermatt, Bernhard
  • Ho, Alexandra
  • Bouchard, Denis
  • Whorisky, John S
  • Jordana, Manel
  • Ohashi, Pamela S
  • Pawson, Tony
  • Bladt, Friedhelm
  • Tafuri, Anna

publication date

  • August 2003