Journal article
Characterization of nickel-induced mutations
Abstract
A Chinese hamster ovary cell line (designated AS52) has been used to test the mutagenicity of nickel compounds. This line lacks the endogenous gene for hypoxanthine phosphoribosyl transferase (HPRT) but contains an inserted bacterial gene coding for the enzyme guanine-hypoxanthine phosphoribosyl transferase (gpt) which is the targeted locus for selection. Isolated mutants were clonally expanded and analysed utilizing the polymerase chain …
Authors
Rossetto FE; Turnbull JD; Nieboer E
Journal
The Science of The Total Environment, Vol. 148, No. 2-3, pp. 201–206
Publisher
Elsevier
Publication Date
June 1994
DOI
10.1016/0048-9697(94)90397-2
ISSN
0048-9697