Journal article
Diagnostic testing for α‐globin gene disorders in a heterogeneous North American population
Abstract
Adult hemoglobin is a heterotetramer composed of two α-globin chains and two β-globin chains (α2 β2 ), each of which contains a heme molecule capable of binding oxygen and facilitating oxygen transport. The α-globin chains are expressed from duplicated genes within a tandem gene cluster located on chromosome region 16p13.3. High-level expression of the α-globin genes commences early in fetal development and continues throughout life. The …
Authors
Waye JS; Eng B
Journal
International Journal of Laboratory Hematology, Vol. 35, No. 3, pp. 306–313
Publisher
Wiley
Publication Date
June 2013
DOI
10.1111/ijlh.12066
ISSN
1751-5521