Prothrombin Concept

subject area of

• A Control Switch for Prothrombinase  Journal Articles
• A Protease TAMER: a nucleic acid‐based anticoagulant  Journal Articles
• A single dose of aprotinin prevents platelet hyporeactivity after coronary artery bypass graft surgery  Journal Articles
• A549 Lung Epithelial Cells Synthesize Anticoagulant Molecules on the Cell Surface and Matrix and in Conditioned Media  Journal Articles
• Activated prothrombin complex concentrate for dabigatran‐associated bleeding  Journal Articles
• Activation of factor X and prothrombin in antithrombin-III depleted plasma: The effects of heparin  Journal Articles
• Age-related differences in heparin response  Journal Articles
• Age‐related changes in factor VII proteolysis in vivo  Journal Articles
• Altered regulation of in-vivo coagulation in orthopedic patients prior to knee or hip replacement surgery  Journal Articles
• An Antithrombin III Assay Based on Factor Xa Inhibition Provides a More Reliable Test to Identify Congenital Antithrombin III Deficiency Than an Assay Based on Thrombin Inhibition  Journal Articles
• An Approach to Assigning In Vitro Potency to Unfractionated and Low Molecular Weight Heparins Based on the Inhibition of Prothrombin Activation and Catalysis of Thrombin Inhibition  Journal Articles
• An Increased Uptake of Prothrombin, Antithrombin, and Fibrinogen by the Rabbit Balloon-Deendothelialized Aorta Surface In Vivo Is Maintained Until Reendothelialization Is Complete  Journal Articles
• Andexanet Alfa for the Reversal of Factor Xa Inhibitor Activity  Journal Articles
• Anti-prothrombin antibodies and other acquired antibodies associated with thrombosis in children  Journal Articles
• Anticoagulant Actions of Tissue Factor Pathway Inhibitor on Tissue-Factor-Dependent Plasma Coagulation  Journal Articles
• Anticoagulant Mechanisms of Orgaran (Org 10172) and Its Fraction with High Affinity to Antithrombin III (Org 10849)  Journal Articles
• Are There Patients With Acute Ischemic Stroke and Atrial Fibrillation That Benefit From Low Molecular Weight Heparin?  Journal Articles
• Beyond Unfractionated Heparin and Warfarin  Journal Articles
• Bleeding and antidotes in new oral anticoagulants  Journal Articles
• Catabolism of rabbit prothrombin in rabbits: uptake of prothrombin by the aorta wall before and after a de-endothelializing injury in vivo.  Journal Articles
• Challenges with heparin-based anticoagulation during cardiopulmonary bypass in children: Impact of low antithrombin activity  Journal Articles
• Comparative catabolism of prothrombin and antithrombin in normal and alloxan-diabetic rabbits  Journal Articles
• Comparison of 1 month with 3 months of anticoagulation for a first episode of venous thromboembolism associated with a transient risk factor  Journal Articles
• Comparison of 5-mg and 10-mg Loading Doses in Initiation of Warfarin Therapy  Journal Articles
• Comparison of three‐factor and four‐factor prothrombin complex concentrates regarding reversal of the anticoagulant effects of rivaroxaban in healthy volunteers  Journal Articles
• Conformational Changes in Thrombin When Complexed by Serpins  Journal Articles
• Covalent antithrombin-heparin effect on thrombin-thrombomodulin and activated protein C reaction with factor V/Va  Journal Articles
• Decreased Concentrations of Heparinoids Are Required to Inhibit Thrombin Generation in Plasma from Newborns and Children Compared to Plasma from Adults due to Reduced Thrombin Potential  Journal Articles
• Decreased Thrombin Activity of Fibrin Clots Prepared in Cord Plasma Compared with Adult Plasma  Journal Articles
• Differences in prethrombin-1 activation with human or bovine factor Va can be attributed to the heavy chain  Journal Articles
• Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish  Journal Articles
• Duration of anticoagulant therapy for venous thromboembolism  Journal Articles
• EFFECT OF SERA ON THROMBIN ACTIVATION RATE CONSTANTS: A ONE‐STAGE ASSAY OF THE EXTRINSIC SYSTEM  Journal Articles
• Effect of Covalent Serpin–Heparinoid Complexes on Plasma Thrombin Generation on Fetal Distal Lung Epithelium  Journal Articles
• Effect of Heparin Loading During Congenital Heart Operation on Thrombin Generation and Blood Loss  Journal Articles
• Effect of a novel covalent antithrombin-heparin complex on thrombin generation on fetal distal lung epithelium  Journal Articles
• Effects of Dermatan Sulfate and Heparin on Inhibition of Thrombus Growth in Vivo  Journal Articles
• Effects on Thrombin Generation of Single Injections of Hirulog™ in Patients with Calf Vein Thrombosis  Journal Articles
• EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis  Journal Articles
• Evidence for Allosteric Linkage between Exosites 1 and 2 of Thrombin  Journal Articles
• Evolving Treatments for Arterial and Venous Thrombosis  Journal Articles
• Factor V Leiden and prothrombin gene G20210A mutations in Italian patients with Behçet's disease and deep vein thrombosis  Journal Articles
• Factors That Predict Risk of Thrombosis in Relatives of Patients With Unprovoked Venous Thromboembolism  Journal Articles
• Factors that predict thrombosis in relatives of patients with venous thromboembolism  Journal Articles
• Familial thrombophilia and the prothrombin 20210A mutation  Journal Articles
• Fibrinolytic properties of lysine‐derivatized polyethylene in contact with flowing whole blood (Chandler loop model)  Journal Articles
• Four-Factor Prothrombin Complex Concentrate for Urgent Reversal of Vitamin K Antagonists in Patients With Major Bleeding  Journal Articles
• Further Evidence for Two Functional Forms of Prothrombinase Each Specific for Either of the Two Prothrombin Activation Cleavages  Journal Articles
• HD1, a Thrombin-directed Aptamer, Binds Exosite 1 on Prothrombin with High Affinity and Inhibits Its Activation by Prothrombinase  Journal Articles
• HD1, a thrombin- and prothrombin-binding DNA aptamer, inhibits thrombin generation by attenuating prothrombin activation and thrombin feedback reactions  Journal Articles
• Hemorrhagic Complications Following Abdominal Paracentesis in Acute on Chronic Liver Failure: A Propensity Score Analysis.  Journal Articles
• Hemostatic System Activation in Patients with Lupus Anticoagulant and Essential Thrombocythemia  Journal Articles
• Heparan sulfate and dermatan sulfate inhibit the generation of thrombin activity in plasma by complementary pathways  Journal Articles
• Heparan sulfate and dermatan sulfate inhibit the generation of thrombin activity in plasma by complementary pathways.  Journal Articles
• Heparin and Low Molecular Weight Heparins Inhibit Prothrombinase Formation but not its Activity in Plasma  Journal Articles
• Heparin sensitivity and resistance in the neonate: An explanation  Journal Articles
• Heparin with low affinity to antithrombin III inhibits the activation of prothrombin in normal plasma  Journal Articles
• Hypercoagulable States  Journal Articles
• Iatrogenic causes of an ICH  Journal Articles
• Identification and characterization of a factor Va-binding site on human prothrombin fragment 2  Journal Articles
• Identification of a Unique Glomerular Factor X Activator in Murine Lupus Nephritis  Journal Articles
• Impact of simvastatin on hemostatic and fibrinolytic regulators in Type 2 diabetes mellitus  Journal Articles
• In the Presence of Phospholipids, Glycosaminoglycans Potentiate Factor Xa-Mediated Protein C Activation by Modulating Factor Xa Activity  Journal Articles
• In vitro and ex vivo Activities of CY216: Comparison with Other Low Molecular Weight Heparins  Journal Articles
• Incorporation of Factor Va into Prothrombinase Is Required for Coordinated Cleavage of Prothrombin by Factor Xa  Journal Articles
• Increased sulphation improves the anticoagulant activities of heparan sulphate and dermatan sulphate  Journal Articles
• Inherited Thrombophilia in Childhood Arterial Stroke: Data from Lebanon  Journal Articles
• Inhibition of factor X and factor V activation by dermatan sulfate and a pentasaccharide with high affinity for antithrombin III in human plasma  Journal Articles
• Inhibition of factor X, factor V and prothrombin activation by the bis(lactobionic acid amide) LW10082  Journal Articles
• Inhibition of the amplification reactions of blood coagulation by site-specific inhibitors of α-thrombin  Journal Articles
• Inhibition of thrombin generation by simvastatin and lack of additive effects of aspirin in patients with marked hypercholesterolemia  Journal Articles
• Interactions of heparin and a covalently-linked antithrombin-heparin complex with components of the fibrinolytic system  Journal Articles
• International Council for Standardization in Haematology (ICSH) Recommendations for Laboratory Measurement of Direct Oral Anticoagulants  Journal Articles
• Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara  Journal Articles
• Localization of the Thrombin-binding Domain on Prothrombin Fragment 2  Journal Articles
• Measurement of Markers of Activated Coagulation in Antithrombin III Deficient Subjects  Journal Articles
• Measurement of factor Xa‐antithrombin III in plasma: relationship to prothrombin activation in vivo  Journal Articles
• Mechanism of inhibition of the prothrombinase complex by a covalent antithrombin-heparin complex  Journal Articles
• Mechanisms for Inhibition of the Generation of Thrombin Activity by Sulfated Polysaccharides^a  Journal Articles
• Mechanisms for the Anticoagulant Effects of Synthetic Antithrombins  Journal Articles
• Mechanisms responsible for the failure of protamine 
to inactivate low‐molecular‐weight heparin  Journal Articles
• Mesenteric-portal Vein Thrombosis in a Patient with Hyperhomocysteinemia and Heterozygous for 20210A Prothrombin Allele  Journal Articles
• Metabolism of rabbit plasma-derived factor VII in relation to prothrombin in rabbits  Journal Articles
• Minimal impact of anticoagulant on in vitro whole blood quality throughout a 35‐day cold‐storage regardless of leukoreduction timing  Journal Articles
• Modulation of intrinsic prothrombin activation by fibrinogen and fibrin I.  Journal Articles
• No Association between the 20210 G/A Prothrombin Gene Mutation and Premature Coronary Artery Disease  Journal Articles
• Optimal reversal of vitamin K antagonists  Journal Articles
• Periprocedural management of patients receiving a vitamin K antagonist or a direct oral anticoagulant requiring an elective procedure or surgery  Journal Articles
• Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by Pseudomonas aeruginosa virulence factor pyocyanin  Journal Articles
• Plasma Anticoagulant Mechanisms of Heparin, Heparan Sulfate, and Dermatan Sulfatea  Journal Articles
• Plasma Thrombin Neutralization Assay: Pharmacokinetic Applications  Journal Articles
• Plasminogen II accumulates five times faster than plasminogen I at the site of a balloon de-endothelializing injury in vivo to the rabbit aorta: Comparison with other hemostatic proteins  Journal Articles
• Preclinical differentiation of low molecular weight heparins.  Journal Articles
• Predictors of the post‐thrombotic syndrome during long‐term treatment of proximal deep vein thrombosis  Journal Articles
• Probable regulation of factor VIIa–tissue factor and prothrombinase by factor Xa–TFPI and TFPI in vivo  Journal Articles
• Prolonged Expression of Procoagulant Activity of Human Platelets Degranulated by Thrombin  Journal Articles
• Prolonged hemorrhagic shock does not impair regeneration of plasma coagulant masses in the rabbit  Journal Articles
• Prophylactic doses of enoxaparin and heparin inhibit prothrombin activation.  Journal Articles
• Prophylactically Effective Doses of Enoxaparin and Heparin Inhibit Prothrombin Activation  Journal Articles
• Proteomic analysis of plasma from Holstein cows testing positive for mycobacterium avium subsp. Paratuberculosis (MAP)  Journal Articles
• Prothrombin 20210A and familial thrombophilia  Journal Articles
• Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate  Journal Articles
• Prothrombin, alone or in complex concentrates or plasma, reduces bleeding in a mouse model of blood exchange-induced coagulopathy  Journal Articles
• Prothrombotic Disorders in Infants and Children With Cerebral Thromboembolism  Journal Articles
• Rapid diagnosis of coagulopathies from vitamin K deficiency in a consecutive case cohort evaluated by comparative assessment of factor II by one stage assays with prothrombin time versus Ecarin reagents  Journal Articles
• Rationale Behind the Development of Low Molecular Weight Heparin Derivatives  Journal Articles
• Reactivation of coagulation after stopping infusions of recombinant hirudin and unfractionated heparin in unstable angina and myocardial infarction without ST elevation: results of a randomized trial  Journal Articles
• Relationship Between Thromboembolic Complications and Intensity of Treatment During Long-Term Prophylaxis with Oral Anticoagulants Following DVT  Journal Articles
• Reliability of the international normalized ratio for monitoring the induction phase of warfarin: Comparison with the prothrombin time ratio  Journal Articles
• Review: Laboratory markers quantifying prothrombin activation and actions of thrombin in venous and arterial thrombosis do not accurately assess disease severity or the effectiveness of treatment  Journal Articles
• Risk of Recurrent Venous Thromboembolism in Patients With Common Thrombophilia  Journal Articles
• Role of thrombophilic risk factors in children with non-stroke cerebral palsy  Journal Articles
• SR123781A: A New Once-Daily Synthetic Oligosaccharide Anticoagulant for Thromboprophylaxis After Total Hip Replacement Surgery  Journal Articles
• Serum-induced platelet procoagulant activity: An assay for the characterization of prothrombotic disorders  Journal Articles
• Suboptimal effect of a three‐factor prothrombin complex concentrate (Profilnine‐SD) in correcting supratherapeutic international normalized ratio due to warfarin overdose  Journal Articles
• Synthesis and turnover of prothrombin during experimental inflammation in rats.  Journal Articles
• The Antithrombotic Properties of Human Prothrombin Fragment 1.2 in Mice  Journal Articles
• The Effect of Prothrombotic Blood Abnormalities on Risk of Deep Vein Thrombosis in Users of Hormone Replacement Therapy  Journal Articles
• The Effects of Hormone Replacement Therapy on Thrombin Generation, Fibrinolysis Inhibition, and Resistance to Activated Protein C  Journal Articles
• The Procoagulant State of the VX-2 Tumor in Rabbit Lung In Vivo  Journal Articles
• The Risk of Recurrent Venous Thromboembolism in Carriers and Non-carriers of the G1691A Allele in the Coagulation Factor V Gene and the G20210A Allele in the Prothrombin Gene  Journal Articles
• The activation of coagulation by extracts of mucus: a possible pathway of intravascular coagulation accompanying adenocarcinomas.  Journal Articles
• The affinity of human, rabbit and bovine thrombins for sepharose-lysine and other conjugates  Journal Articles
• The blood platelet as a model for regulating blood coagulation on cell surfaces and its consequences.  Journal Articles
• The direct thrombin inhibitor hirudin  Journal Articles
• The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces  Journal Articles
• The hypercoagulable state in cancer patients  Journal Articles
• The importance of thrombin inhibition for the expression of the anticoagulant activities of heparin, dermatan sulphate, low molecular weight heparin and pentosan polysulphate  Journal Articles
• The inhibition of thrombin-dependent positive-feedback reactions is critical to the expression of the anticoagulant effect of heparin  Journal Articles
• The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase  Journal Articles
• The isolation of prothrombin, factor IX and factor X from human factor IX concentrates  Journal Articles
• The low molecular weight heparin Enoxaparin inhibits the consumption of factor VII and prothrombin activation in vivo associated with elective knee replacement surgery  Journal Articles
• The risk of major bleeding in patients with factor V Leiden or prothrombin G20210A gene mutation while on extended anticoagulant treatment for venous thromboembolism  Journal Articles
• The risk of recurrent venous thromboembolism in carriers and non-carriers of the G1691A allele in the coagulation factor V gene and the G20210A allele in the prothrombin gene. DURAC Trial Study Group. Duration of Anticoagulation.  Journal Articles
• Thrombin Generation and Presence of Thrombin Receptor in Ovarian Follicles1  Journal Articles
• Thrombin Generation during Cardiac Surgery: Is Heparin the Ideal Anticoagulant?  Journal Articles
• Thrombin Generation in Newborn Plasma Is Critically Dependent on the Concentration of Prothrombin  Journal Articles
• Thrombin Inhibition Is Impaired in Plasma of Sick Neonates  Journal Articles
• Thrombin Inhibition by Hirudin: How Hirudin Inhibits Thrombin  Journal Articles
• Thrombin Regulation in Children Differs from Adults in the Absence and Presence of Heparin  Journal Articles
• Thrombin and Antithrombotics  Journal Articles
• Thrombin binding to platelets and their activation in plasma  Journal Articles
• Thromboembolic safety and efficacy of prothrombin complex concentrates in the emergency reversal of warfarin coagulopathy  Journal Articles
• Thromboepidemiology: Identifying patients with heritable risk for thrombin-mediated thromboembolic events  Journal Articles
• Thrombophilia and location of venous thromboembolism  Journal Articles
• Thrombosis in Children  Journal Articles
• Thrombosis in inherited factor VII deficiency  Journal Articles
• Towards the genetic basis of cerebral venous thrombosis—the BEAST Consortium: a study protocol  Journal Articles
• Undercarboxylation of recombinant prothrombin revealed by analysis of γ‐carboxyglutamic acid using capillary electrophoresis and laser‐induced fluorescence  Journal Articles
• Unfractionated heparin inhibits thrombin-catalysed amplification reactions of coagulation more efficiently than those catalysed by factor Xa  Journal Articles
• Uptake of heparin cofactor II and antithrombin into the aorta wall after a deendothelializing injury in vivo: Comparison with the behaviors of prothrombin and fibrinogen  Journal Articles
• Why Is Factor Xa Not a Better Target Than Factor IIa for Therapeutic Inhibition of Coagulation?  Journal Articles
• Withdrawal of warfarin after deep vein thrombosis  Journal Articles
• [Prothromplex in stead of Beriplex P/N as acute antidote against warfarin].  Journal Articles
• α2-Macroglobulin Remains as Important as Antithrombin III for Thrombin Regulation in Cord Plasma in the Presence of Endothelial Cell Surfaces  Journal Articles