Journal article
EspP, an Extracellular Serine Protease from Enterohemorrhagic E. coli, Reduces Coagulation Factor Activities, Reduces Clot Strength, and Promotes Clot Lysis
Abstract
BACKGROUND: EspP (E. coli secreted serine protease, large plasmid encoded) is an extracellular serine protease produced by enterohemorrhagic E. coli (EHEC) O157:H7, a causative agent of diarrhea-associated Hemolytic Uremic Syndrome (D+HUS). The mechanism by which EHEC induces D+HUS has not been fully elucidated.
OBJECTIVES: We investigated the effects of EspP on clot formation and lysis in human blood.
Authors
Kuo KHM; Khan S; Rand ML; Mian HS; Brnjac E; Sandercock LE; Akula I; Julien J-P; Pai EF; Chesney AE
Journal
PLOS ONE, Vol. 11, No. 3,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0149830
ISSN
1932-6203
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Blood CoagulationBlood Coagulation DisordersBlood Coagulation FactorsEnterohemorrhagic Escherichia coliEscherichia coli O157Escherichia coli ProteinsFibrin Clot Lysis TimeFibrinolysisHemolytic-Uremic SyndromeHumansPartial Thromboplastin TimeProthrombinProthrombin TimeSerine EndopeptidasesSerine ProteasesThrombosis