Journal article
Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish
Abstract
The ability to prevent blood loss in response to injury is a conserved function of all vertebrates. Complete deficiency of the central clotting enzyme prothrombin has never been observed in humans and is incompatible with postnatal life in mice, thus limiting the ability to study its role in vivo. Zebrafish are able to tolerate severe hemostatic deficiencies that are lethal in mammals. We have generated a targeted genetic deletion in the …
Authors
Grzegorski SJ; Hu Z; Liu Y; Yu X; Ferguson AC; Madarati H; Friedmann AP; Reyon D; Kim PY; Kretz CA
Journal
Scientific Reports, Vol. 10, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41598-020-60840-7
ISSN
2045-2322