Journal article
Mechanisms for the Anticoagulant Effects of Synthetic Antithrombins
Abstract
The important roles of thrombin in the development and propagation of thrombosis are well recognized. In addition to being the enzyme for clotting fibrinogen (the major protein component of blood clots), thrombin accelerates its own generation by activating factor V, factor VIII, factor XI and platelets. It accelerates the stabilization of clots by activating factor XIII to factor XIIIa, the enzyme which crosslinks fibrin. There are probably …
Authors
Ofosu FA
Journal
Advances in Experimental Medicine and Biology, Vol. 340, , pp. 213–226
Publisher
Springer Nature
Publication Date
1993
DOI
10.1007/978-1-4899-2418-6_19
ISSN
0065-2598