Journal article
Isolation and characterization of cotiaractivase, a novel low molecular weight prothrombin activator from the venom of Bothrops cotiara
Abstract
In this study, we isolated a novel prothrombin activator from the venom of Bothrops cotiara, a Brazilian lance-headed pit viper (Cotiara, Jararaca preta, Biocotiara), which we have designated "cotiaractivase" (prefix: cotiar- from B. cotiara; suffix: -activase, from prothrombin activating activity). Cotiaractivase was purified using a phenyl-Superose hydrophobic interaction column followed by a Mono-Q anion exchange column. It is a single-chain …
Authors
Senis YA; Kim PY; Fuller GLJ; García Á; Prabhakar S; Wilkinson MC; Brittan H; Zitzmann N; Wait R; Warrell DA
Journal
Biochimica et Biophysica Acta, Vol. 1764, No. 5, pp. 863–871
Publisher
Elsevier
Publication Date
5 2006
DOI
10.1016/j.bbapap.2006.03.004
ISSN
0006-3002