Journal article
Anticoagulant Actions of Tissue Factor Pathway Inhibitor on Tissue-Factor-Dependent Plasma Coagulation
Abstract
The initiation and propagation of in vivo coagulation are thought to be catalyzed by factor VIIa-tissue factor (an activator of factor X and factor IX) and factor IXa-factor VIIIa (an activator of factor IX), respectively. The enzymatic activity of factor VIIa-tissue factor is abrogated by tissue factor pathway inhibitor (TFPI), which anchors a quaternary complex consisting of equimolar TFPI, factor Xa, factor VIIa, and tissue factor in which …
Authors
Ofosu F
Journal
Seminars in Thrombosis and Hemostasis, Vol. 21, No. 02, pp. 240–244
Publisher
Thieme
Publication Date
4 1995
DOI
10.1055/s-2007-1000399
ISSN
0094-6176