Multicenter Studies as Topic Concept

subject area of

• A Challenging Question Regarding the Use of Topical Corticosteroids for Mycosis Fungoides  Academic Article
• A Practical Guide to Research: Design, Execution, and Publication  Academic Article
• A community-based clinical trial of Intra-Venous zOledRonic acid once Yearly in comparison to oral bisphosphonates in postmenopausal women with osteoporosis: The IVORY trial  Academic Article
• A multinational registry to study the characteristics and outcomes of heart failure patients: The global congestive heart failure (G-CHF) registry  Academic Article
• A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis Genetic modifier studies  Academic Article
• A phase II clinical and pharmacokinetic study of intravenous exatecan mesylate (DX-8951f) in patients with untreated metastatic gastric cancer  Academic Article
• A prediction model for sudden cardiac death in patients with heart failure and preserved ejection fraction  Academic Article
• A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol  Academic Article
• A review of exemestane in the management of breast cancer  Academic Article
• A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial  Academic Article
• ASymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the atrial fibrillation Reduction atrial pacing Trial (ASSERT)  Academic Article
• Accumulation of Deficits as a Key Risk Factor for Cardiovascular Morbidity and Mortality: A Pooled Analysis of 154 000 Individuals  Academic Article
• Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials  Academic Article
• Acupuncture treatment for knee osteoarthritis with sensitive points: protocol for a multicentre randomised controlled trial  Academic Article
• Acute myelogenous leukemia in adolescents and young adults  Academic Article
• Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol  Academic Article
• Adjudicating Outcomes: Fundamentals  Academic Article
• Adjudicating ventilator-associated pneumonia in a randomized trial of critically ill patients  Academic Article
• Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials  Academic Article
• Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis  Academic Article
• Adjuvant/neoadjuvant trastuzumab therapy in women with HER-2/neu-overexpressing breast cancer: A systematic review  Academic Article
• Age of the female partner is a prognostic factor in prolonged unexplained infertility: a multicenter study *†  Academic Article
• Agreement in reporting between trial publications and current clinical trial registry in high impact journals: A methodological review  Academic Article
• Analysis of Regional Timelines To Set Up a Global Phase III Clinical Trial in Breast Cancer: The Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Experience  Academic Article
• Antibiotic Review Kit for Hospitals (ARK-Hospital): study protocol for a stepped-wedge cluster-randomised controlled trial  Academic Article
• Anticoagulant therapy after acute myocardial infarction  Academic Article
• Antivirals for influenza-Like Illness? A randomised Controlled trial of Clinical and Cost effectiveness in primary CarE (ALIC4E): the ALIC4E protocol  Academic Article
• Are large clinical trials in orthopaedic trauma justified?  Academic Article
• Aspirin Versus Low-Molecular-Weight Heparin for Ischemic Stroke in Children: An Unanswered Question  Academic Article
• Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study  Academic Article
• Association of cyclooxygenase-2 genetic variant with cardiovascular disease  Academic Article
• Association of mitral annular calcification and aortic valve morphology: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study  Academic Article
• At-risk registers integrated into primary care to stop asthma crises in the UK (ARRISA-UK): study protocol for a pragmatic, cluster randomised trial with nested health economic and process evaluations  Academic Article
• Becoming and staying physically active in adolescents with cerebral palsy: protocol of a qualitative study of facilitators and barriers to physical activity  Academic Article
• Bone Turnover Markers as Predictors of Skeletal Complications in Prostate Cancer, Lung Cancer, and Other Solid Tumors  Academic Article
• Burden of Proof for Tolvaptan in ADPKD  Academic Article
• Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies  Academic Article
• CANadian Network and Centre for Trials INternationally (CANNeCTIN): A national network for Canadian-led trials in cardiovascular diseases and diabetes mellitus  Academic Article
• Can orthopedic trials change practice?  Academic Article
• Candidemia in patients with diabetes mellitus: epidemiology and predictors of mortality  Academic Article
• Care and outcomes of Canadian children hospitalised with periorbital and orbital cellulitis: protocol for a multicentre, retrospective cohort study  Academic Article
• Carotid plaque formation and its evaluation with angiography, ultrasound, and MR angiography  Academic Article
• Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections  Academic Article
• Central statistical monitoring: Detecting fraud in clinical trials  Academic Article
• Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction  Academic Article
• Challenges to complete and useful data sharing  Academic Article
• Choices of Methodology in Pharmacoeconomic Studies  Academic Article
• Choisir un questionnaire de qualité de vie  Academic Article
• Classification and appraisal of the level of clinical evidence of publications from the Canadian Association of Pediatric Surgeons for the past 10 years  Academic Article
• Clinical trial update: National Cancer Institute of Canada  Academic Article
• Coached, Coordinated, Enhanced Neonatal Transition (CCENT): protocol for a multicentre pragmatic randomised controlled trial of transition-to-home support for parents of high-risk infants  Academic Article
• Cognitive Outcomes after DEXmedetomidine sedation in cardiac surgery: CODEX randomised controlled trial protocol  Academic Article
• Cognitive impairment and risk of cardiovascular events and mortality  Academic Article
• Collaborative multicenter trials in Latin America: challenges and opportunities in orthopedic and trauma surgery  Academic Article
• Combined Analysis of Asthma Safety Trials of Long-Acting β2-Agonists  Academic Article
• Comment on ‘A multicentre randomized controlled trial of expectant management versus IVF in women with Fallopian tube patency’  Academic Article
• Comparative Therapeutic Studies with Tilavist  Academic Article
• Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study  Academic Article
• Comparison of 12 Risk Stratification Schemes to Predict Stroke in Patients With Nonvalvular Atrial Fibrillation  Academic Article
• Comparisons of cause of death verification methods and costs in the lipid research clinics program mortality follow-up study  Academic Article
• Complex care for kids Ontario: protocol for a mixed-methods randomised controlled trial of a population-level care coordination initiative for children with medical complexity  Academic Article
• Conducting economic evaluations alongside multinational clinical trials: Toward a research consensus  Academic Article
• Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials  Academic Article
• Construction of a FRAX® model for the assessment of fracture probability in Canada and implications for treatment  Academic Article
• Contrasting evidence to reimbursement reality for off-label use (OLU) of drug treatments in cancer care: rationale and design of the CEIT-OLU project  Academic Article
• Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial  Academic Article
• Coordination of international multicenter studies: governance and administrative structure  Academic Article
• Coronary stenting in diabetic patients: Results from the ROSETTA registry  Academic Article
• Cost Implications of the Use of Ramipril in High-Risk Patients Based on the Heart Outcomes Prevention Evaluation (HOPE) Study  Academic Article
• Cost‐effectiveness analysis of a multinational RCT with a binary measure of effectiveness and an interacting covariate  Academic Article
• Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis  Academic Article
• Cytoreductive nephrectomy in metastatic renal cell carcinoma: the evolving role of surgery in the era of molecular targeted therapy  Academic Article
• Design and Analytic Considerations in Determining the Cost-Effectiveness of Early Intervention in Asthma from a Multinational Clinical Trial  Academic Article
• Design and baseline characteristics of participants in the R esearching cardiovascular E vents with a W eekly IN cretin in D iabetes ( REWIND ) trial on the cardiovascular effects of dulaglutide  Academic Article
• Design and rationale of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial  Academic Article
• Design of the INPULSIS™ trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis  Academic Article
• Development of a clinical prediction model for the postthrombotic syndrome in a prospective cohort of patients with proximal deep vein thrombosis  Academic Article
• Diabetes mellitus, a predictor of morbidity and mortality in the studies of left ventricular dysfunction (SOLVD) trials and registry  Academic Article
• Diarrhoea: interventions, consequences and epidemiology in the intensive care unit (DICE-ICU): a protocol for a prospective multicentre cohort study  Academic Article
• Donepezil and rivastigmine in the treatment of Alzheimer's disease: a best-evidence synthesis of the published data on their efficacy and cost-effectiveness  Academic Article
• Economic Evaluation of Rivastigmine in Patients with Parkinson??s Disease Dementia  Academic Article
• Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol  Academic Article
• Effect of Angiotensin-Converting Enzyme Inhibitors in Left Ventricular Dysfunction  Academic Article
• Effect of acute angiotensin converting enzyme inhibition on left ventricular filling in patients with congestive heart failure. Relation to right ventricular volumes.  Academic Article
• Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: the DIG study  Academic Article
• Effect of visceral metastases on the efficacy and safety of everolimus in postmenopausal women with advanced breast cancer: Subgroup analysis from the BOLERO-2 study  Academic Article
• Effectiveness and safety of Chinese herbal medicine xuanbi antong granules for the treatment of borderline coronary lesions: study protocol for a randomised, double-blinded, placebo-controlled, multicentre clinical trial  Academic Article
• Effectiveness of Dorzolamide–Timolol (COSOPT) in Patients Who Were Treatment Naive for Open-Angle Glaucoma or Ocular Hypertension: The COSOPT First-Line Study  Academic Article
• Effects of Dronedarone Started Rapidly After Amiodarone Discontinuation  Academic Article
• Effects of exercise interventions on cardiovascular health in individuals with chronic, motor complete spinal cord injury: protocol for a randomised controlled trial [Cardiovascular Health/Outcomes: Improvements Created by Exercise and education in SCI (CHOICES) Study]  Academic Article
• Efficacy and tolerability of a “suprabioavailable” formulation of fenofibrate in patients with dyslipidemia: a pooled analysis of two open-label trials  Academic Article
• El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos  Academic Article
• Emergence of the Primary Pediatric Stroke Center  Academic Article
• Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel  Academic Article
• Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT  Academic Article
• Evaluating the effectiveness of rosuvastatin in preventing the progression of diastolic dysfunction in aortic stenosis: A substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study  Academic Article
• Evaluation of Buspirone as an Antianxiety Agent: Buspirone and Diazepam versus Placebo*  Academic Article
• Evaluation of outcome and cost-effectiveness using an FDG PET-guided approach to management of patients with coronary disease and severe left ventricular dysfunction (PARR-2): rationale, design, and methods  Academic Article
• Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis  Academic Article
• Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol  Academic Article
• Factors affecting blood pressure responses to diet: The vanguard study  Academic Article
• Favourable outcome in 135 children with juvenile systemic sclerosis: results of a multi‐national survey  Academic Article
• Feasibility study protocol of a pragmatic, randomised controlled pilot trial: membrane sweeping to prevent post-term pregnancy—the MILO Study  Academic Article
• Femoroacetabular Impingement Randomised controlled Trial (FIRST) - a multi-centre randomized controlled trial comparing arthroscopic lavage and arthroscopic osteochondroplasty on patient important outcomes and quality of life in the treatment of young adult (18–50 years) femoroacetabular impingement: a statistical analysis plan  Academic Article
• Fondaparinux vs Enoxaparin for the Prevention of Venous Thromboembolism in Major Orthopedic SurgeryA Meta-analysis of 4 Randomized Double-blind Studies  Academic Article
• Fracture Risk Assessment in Chronic Kidney Disease, Prospective Testing Under Real World Environments (FRACTURE): a prospective study  Academic Article
• Fracture prediction and calibration of a Canadian FRAX® tool: a population-based report from CaMos  Academic Article
• Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial  Academic Article
• Gemifloxacin versus Amoxicillin/Clavulanate in the Treatment of Acute Exacerbations of Chronic Bronchitis  Academic Article
• Generalizability of results from the recent FDA-guided cardiovascular outcomes trials to a representative population with Type 2 Diabetes attending primary care clinics  Academic Article
• Globally optimal trial design for local decision making  Academic Article
• Haemorrhagic and thromboembolic complications versus intensity of treatment of venous thromboembolism with oral anticoagulants.  Academic Article
• Health-Related Quality of Life at Age 10 Years in Very Low-Birth-WeightChildren With and Without Threshold Retinopathy of Prematurity  Academic Article
• Hemostatic efficacy of pathogen-inactivated vs untreated platelets: a randomized controlled trial  Academic Article
• High Dose Therapy with Stem Cell Support for Breast Cancer: The Jury Is Still Out  Academic Article
• High-Sensitivity Cardiac Troponin—Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women (CODE-MI): Rationale and design for a multicenter, stepped-wedge, cluster-randomized trial  Academic Article
• Hospital Selection for Unit Cost Estimates in Multicentre Economic Evaluations  Academic Article
• How Did We Get Here?: A Historical Review and Critical Analysis of Anticoagulation Therapy Following Mechanical Valve Replacement  Academic Article
• Human Papillomavirus Triage of Atypical Squamous Cells of Undetermined Significance: Cost-Effective, But At What Cost?  Academic Article
• Immunosuppressive activity in human in vitro fertilization (IVF) culture supernatants and prediction of the outcome of embryo transfer: A multicenter trial  Academic Article
• Impact of Diabetes on Long-Term Prognosis in Patients With Unstable Angina and Non–Q-Wave Myocardial Infarction  Academic Article
• Implementation of Timeline Reforms Speeds Initiation of National Cancer Institute-Sponsored Trials  Academic Article
• Improving management of patients with acute cough by C-reactive protein point of care testing and communication training (IMPAC3T): study protocol of a cluster randomised controlled trial  Academic Article
• Incidence of venous thromboembolism in patients undergoing thoracotomy for lung cancer  Academic Article
• Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia  Academic Article
• Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients  Academic Article
• Individual Patient Data from the Pivotal Randomized Controlled Trials of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation (COMBINE AF): Design and Rationale  Academic Article
• Insights into the role of thrombin in the pathogenesis of recurrent ischaemia after acute coronary syndrome  Academic Article
• Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project  Academic Article
• International longitudinal registry of patients with atrial fibrillation at risk of stroke: Global Anticoagulant Registry in the FIELD (GARFIELD)  Academic Article
• International point prevalence study of Intensive Care Unit transfusion practices—Pilot study in the Netherlands  Academic Article
• Interpreting Geographic Variations in Results of Randomized, Controlled Trials  Academic Article
• Introducing an innovative model of acute paediatric mental health and addictions care to paediatric emergency departments: a protocol for a multicentre prospective cohort study  Academic Article
• Iron overload in myelodysplastic syndromes: Evidence based guidelines from the Canadian consortium on MDS  Academic Article
• Is a Restrictive Transfusion Strategy Safe for Resuscitated and Critically Ill Trauma Patients?  Academic Article
• Launch of the Canadian Neurosurgery Research Collaborative  Academic Article
• Lessons learned from enrollment in the BEST study—A multicenter, randomized trial of group psychosocial support in metastatic breast cancer  Academic Article
• Lessons learned from the DIG trial  Academic Article
• Limiting loss to follow-up in a multicenter randomized trial in orthopedic surgery  Academic Article
• Long-term outcomes of total elbow arthroplasty for distal humeral fracture: results from a prior randomized clinical trial  Academic Article
• Longitudinal Youth in Transition Study (LYiTS): protocol for a multicentre prospective cohort study of youth transitioning out of child and adolescent mental health services at age 18  Academic Article
• Low-Molecular-Weight Heparin or Oral Anticoagulation for Secondary Prevention of Deep Vein Thrombosis in Cancer Patients  Academic Article
• Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis  Academic Article
• Markers of Bone Metabolism and Survival in Men with Hormone-Refractory Metastatic Prostate Cancer  Academic Article
• Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes  Academic Article
• Meta-analysis of antiarrhythmic drug trials  Academic Article
• Moving forward through consensus: protocol for a modified Delphi approach to determine the top research priorities in the field of orthopaedic oncology  Academic Article
• Multicenter Collaboration in Observational Research: Improving Generalizability and Efficiency  Academic Article
• Multicenter Study of General Anesthesia. I. Design and Patient Demography  Academic Article
• Multicenter Study of General Anesthesia. II. Results  Academic Article
• Multicenter clinical research in adult critical care  Academic Article
• Multicentre, single-blind randomised controlled trial comparing MyndMove neuromodulation therapy with conventional therapy in traumatic spinal cord injury: a protocol study  Academic Article
• Multistate Analysis of Skeletal Events in Patients with Bone Metastases  Conference Paper
• National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group Report  Academic Article
• Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials  Academic Article
• New Strategies for the Optimal Use of Platelet Transfusions  Academic Article
• Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness  Academic Article
• Once-Daily Therapy with Ceftriaxone Compared with Daily Multiple-Dose Therapy with Cefotaxime for Serious Bacterial Infections: A Randomized, Double-Blind Study  Academic Article
• Ontario Cancer Research Ethics Board: Lessons Learned From Developing a Multicenter Regional Institutional Review Board  Academic Article
• Opportunities for enhancing the care of older patients with ST-elevation myocardial infarction presenting for primary percutaneous coronary intervention: Rationale and design of the SAFE-STEMI for Seniors trial  Academic Article
• Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery  Academic Article
• Outcome assessment for clinical trials: How many adjudicators do we need?  Academic Article
• Overview of the DIG trial  Academic Article
• POP-Brazil study protocol: a nationwide cross-sectional evaluation of the prevalence and genotype distribution of human papillomavirus (HPV) in Brazil  Academic Article
• PREVENTion of CLots in Orthopaedic Trauma (PREVENT CLOT): a randomised pragmatic trial protocol comparing aspirin versus low-molecular-weight heparin for blood clot prevention in orthopaedic trauma patients  Academic Article
• PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan  Academic Article
• Participating in Multicenter Randomized Controlled Trials: What’s the Relative Value?  Academic Article
• Patient and caregiver involvement in a multicentre clustered hemodialysis trial  Academic Article
• Patient engagement in research related to accelerated surgical care and treatment for hip fracture  Academic Article
• Patterns of Medication Use in Patients With Heart Failure  Academic Article
• Peri-Operative Eltrombopag or Immune Globulin for Patients with Immune Thrombocytopaenia (The Bridging ITP Trial): Methods and Rationale  Academic Article
• Perioperative Troponin Screening Identifies Patients at Higher Risk for Major Cardiovascular Events in Noncardiac Surgery  Academic Article
• Personalized pharmacotherapy in diabetes care using clinical pharmacology data of basal insulin analogues  Academic Article
• Perturbation training to promote safe independent mobility post-stroke: study protocol for a randomized controlled trial  Academic Article
• Pharmacological Actions of Sulodexide  Academic Article
• Physical activity in patients with stable coronary heart disease: an international perspective  Academic Article
• Plasma Matrix Metalloproteinase-9 Level Is Correlated With Left Ventricular Volumes and Ejection Fraction in Patients With Heart Failure  Academic Article
• Plasma exchange in Canada. The Canadian Apheresis Study Group.  Academic Article
• Platelet function testing: does a randomized controlled trial settle the debate?  Academic Article
• Pooling Birth Cohorts in Allergy and Asthma: European Union-Funded Initiatives – A MeDALL, CHICOS, ENRIECO, and GA2LEN Joint Paper  Academic Article
• Positive Effect of Etidronate Therapy Is Maintained After Drug Is Terminated in Patients Using Corticosteroids  Academic Article
• Postmenopausal breast cancer: is the short-term pain worth the long-term gain?  Academic Article
• Potential demographic and baselines variables for risk stratification of high-risk post-myocardial infarction patients in the era of implantable cardioverter-defibrillator — A prognostic indicator  Academic Article
• Practical Understanding of Mean Percent Psoriasis Area and Severity Index Reduction for Biologics  Academic Article
• Predicting Malignancy Risk of Screen-Detected Lung Nodules–Mean Diameter or Volume  Academic Article
• Predictors of clinical outcome in patients with heparin-induced thrombocytopenia treated with direct thrombin inhibition  Academic Article
• Predictors of treatment response in patients with non-erosive reflux disease  Academic Article
• Present criteria for prophylactic ICD implantation: Insights from the EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope) project  Academic Article
• Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial  Academic Article
• Prevention of venous thromboembolism in medical patients with enoxaparin  Academic Article
• Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futility.  Academic Article
• Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Pro: Futility stopping can speed up the development of effective treatments.  Academic Article
• Pro: “Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation”  Academic Article
• Prognostic impact of demographic factors and clinical features on the mode of death in high-risk patients after myocardial infarction - A combined analysis from multicenter trials  Academic Article
• Progression to chronic atrial fibrillation after pacing: the Canadian Trial of Physiologic Pacing  Academic Article
• Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial  Academic Article
• Propensity score matched comparison of subcutaneous and transvenous implantable cardioverter-defibrillator therapy in the SIMPLE and EFFORTLESS studies  Academic Article
• Prospective Surveillance for Primary Bloodstream Infections Occurring in Canadian Hemodialysis Units  Academic Article
• Protecting Human Research Participants: Reading vs Understanding the Consent Form  Academic Article
• Protocol for a multicenter prospective cohort study evaluating sport activity and development of femoroacetabular impingement in the adolescent hip  Academic Article
• Protocol for a multicenter randomized controlled trial comparing a non-opioid prescription to the standard of care for pain control following arthroscopic knee and shoulder surgery  Academic Article
• Protocol for a multicentre, randomised, parallel-control, superiority trial comparing administration of clotting factor concentrates with a standard massive haemorrhage protocol in severely bleeding trauma patients: the FiiRST 2 trial (a 2020 EAST multicentre trial)  Academic Article
• Protocol for a randomised trial evaluating a preconception-early childhood telephone-based intervention with tailored e-health resources for women and their partners to optimise growth and development among children in Canada: a Healthy Life Trajectory Initiative (HeLTI Canada)  Academic Article
• Quality of anticoagulation and use of warfarin-interacting medications in long-term care: A chart review  Academic Article
• Randomization and concealment in surgical trials: a comparison between orthopaedic and non-orthopaedic randomized trials  Academic Article
• Randomized Clinical Trials — Removing Unnecessary Obstacles  Academic Article
• Rationale and design of ePPOP-ID: a multicenter randomized controlled trial using an electronic-personalized program for obesity in pregnancy to improve delivery  Academic Article
• Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) Trial: A randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery  Academic Article
• Rationale, design, implementation, and baseline characteristics of patients in the dig trial: A large, simple, long-term trial to evaluate the effect of digitalis on mortality in heart failure  Academic Article
• Re-evaluation of peri-operative cardiac risk (the MET REPAIR study)  Academic Article
• Recommended Clinical Practices for Maximizing Peritoneal Dialysis Clearances  Academic Article
• Reduction of cardiovascular events and microvascular complications in diabetes with ACE inhibitor treatment: HOPE and MICRO-HOPE  Academic Article
• Refining risk classification in childhood B acute lymphoblastic leukemia: results of DFCI ALL Consortium Protocol 05-001  Academic Article
• Reflections 1 Year Into the 21-Center National Institutes of Health–Funded WRIST Study: A Primer on Conducting a Multicenter Clinical Trial  Academic Article
• Relation of baseline characteristics to suppression of ventricular arrhythmias during placebo and active antiarrhythmic therapy in patients after myocardial infarction.  Academic Article
• Relationship Between A1C and Fasting Plasma Glucose in Dysglycemia or Type 2 Diabetes: An analysis of baseline data from the ORIGIN trial  Academic Article
• Relationship Between Perceived and Measured Changes in Walking After Stroke  Academic Article
• Relationship of Activated Partial Thromboplastin Time to Coronary Events and Bleeding in Patients With Acute Coronary Syndromes Who Receive Heparin  Academic Article
• Renal hypothermia during partial nephrectomy for patients with renal tumours: a randomised controlled clinical trial protocol  Academic Article
• Report From the Ethics Committee for Immunotherapy  Academic Article
• Research ethics board approval for an international thromboprophylaxis trial  Academic Article
• Satisfactory Analgesia with Minimal Emesis in Day Surgeries (SAME DayS): a protocol for a randomised controlled trial of morphine versus hydromorphone  Academic Article
• Second Vasovagal Pacemaker Study (VPS II): Rationale, Design, Results, and Implications for Practice and Future Clinical Trials  Academic Article
• Sharing of Lessons Learned From Multisite Research  Academic Article
• Short-course antimicrobial therapy for paediatric respiratory infections (SAFER): study protocol for a randomized controlled trial  Academic Article
• Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies  Academic Article
• Solute Clearance Approach to Adequacy of Peritoneal Dialysis  Academic Article
• Specific barriers to the conduct of randomized trials  Academic Article
• Standard Surgical Protocol to Treat Elbow Dislocations with Radial Head and Coronoid Fractures  Academic Article
• Statins and Intracerebral Hemorrhage  Academic Article
• Statistical analysis plan for a cluster-randomised trial assessing the effectiveness of implementation of a bedside evidence-based checklist for clinical management of brain-dead potential organ donors in intensive care units: DONORS (Donation Network to Optimise Organ Recovery Study)  Academic Article
• Statistical analysis plan for a cluster-randomized crossover trial comparing the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units (the ICU Visits Study)  Academic Article
• Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial  Academic Article
• Strategies to detect abnormal glucose metabolism in people at high risk of cardiovascular disease from the ORIGIN (Outcome Reduction with Initial Glargine Intervention) trial population  Academic Article
• Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP) randomized controlled trial  Academic Article
• Studies of Left Ventricular Dysfunction (SOLVD)—Rationale, design and methods: Two trials that evaluate the effect of enalapril in patients with reduced ejection fraction  Academic Article
• Study protocol for two complementary trials of non-steroidal or opioid analgesia use for children aged 6 to 17 years with musculoskeletal injuries (the No OUCH study)  Academic Article
• Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy  Academic Article
• Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy  Academic Article
• TB and COVID-19 co-infection: rationale and aims of a global study  Academic Article
• THE CANADIAN AMERICAN TICLOPIDINE STUDY (CATS) IN THROMBOEMBOLIC STROKE  Academic Article
• Temporal evolution in the management of acute ST elevation myocardial infarction: the seven-year GUSTO experience from canada and the united states. The North American GUSTO-I and GUSTO-III investigators.  Academic Article
• Temporal trends on the risk of arrhythmic vs. non-arrhythmic deaths in high-risk patients after myocardial infarction: a combined analysis from multicentre trials  Academic Article
• The Analysis of Multinational Cost-Effectiveness Data for Reimbursement Decisions  Academic Article
• The BEACON study: protocol for a cohort study as part of an evaluation of the effectiveness of smartphone-assisted problem-solving therapy in men who present with intentional self-harm to emergency departments in Ontario  Academic Article
• The CHORUS (Cerivastatin in Heart Outcomes in Renal Disease: Understanding Survival) protocol: a double-blind, placebo-controlled trial in patients with esrd.  Academic Article
• The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Design, organization, and baseline results.  Academic Article
• The Complexity of Conducting a Multicenter Clinical Trial  Academic Article
• The Fluid Study Protocol: A Randomized Controlled Study on the Effects of Bioimpedance Analysis and Vitamin D on Left Ventricular Mass in Peritoneal Dialysis Patients  Academic Article
• The Inhaled Steroid Treatment as Regular Therapy in Early Asthma (START) Study  Academic Article
• The Public Access Defibrillation (PAD) Trial  Academic Article
• The Salmeterol Multicenter Asthma Research Trial  Academic Article
• The Stability study: a protocol for a multicenter randomized clinical trial comparing anterior cruciate ligament reconstruction with and without Lateral Extra-articular Tenodesis in individuals who are at high risk of graft failure  Academic Article
• The Tactics of Large Randomized Trials  Academic Article
• The Value of Washers in Cannulated Screw Fixation of Femoral Neck Fractures  Academic Article
• The cost implications of the use of telmisartan or ramipril in patients at high risk for vascular events: the ONTARGET study  Academic Article
• The effects of nocturnal hemodialysis compared to conventional hemodialysis on change in left ventricular mass: Rationale and study design of a randomized controlled pilot study  Academic Article
• The role of the data coordinating center in the DIG trial  Academic Article
• The role of the data coordinating center in the IRB review and approval process: the DIG trial experience  Academic Article
• The role of the pharmacy coordinating center in the DIG trial  Academic Article
• The “parallel-cohort RCT”: Novel design aspects and application in the Kids-DOTT trial of pediatric venous thromboembolism  Academic Article
• Thrombosis prophylaxis in the acutely ill medical patient: insights from the prophylaxis in medical patients with enoxaparin (MEDENOX) trial  Academic Article
• Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction  Academic Article
• Tocilizumab did not reduce hypoxemic respiratory failure or death in hospitalized patients with COVID-19  Academic Article
• Treatment strategies in elderly patients with aggressive histology lymphoma.  Academic Article
• Trends in the utilization and wastage of coagulation factor concentrates: the application of a regional tracking programme  Academic Article
• Use of the day 6 bone marrow to alter remission induction therapy in patients with acute myeloid leukaemia: a leukemia intergroup study  Academic Article
• Variations between countries in invasive cardiac procedures  Academic Article
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