Multicenter Studies as Topic Concept

subject area of

• A Challenging Question Regarding the Use of Topical Corticosteroids for Mycosis Fungoides  Academic Article
• A Practical Guide to Research: Design, Execution, and Publication  Academic Article
• A community-based clinical trial of Intra-Venous zOledRonic acid once Yearly in comparison to oral bisphosphonates in postmenopausal women with osteoporosis: The IVORY trial  Academic Article
• A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis Genetic modifier studies  Academic Article
• A phase II clinical and pharmacokinetic study of intravenous exatecan mesylate (DX-8951f) in patients with untreated metastatic gastric cancer  Academic Article
• A prediction model for sudden cardiac death in patients with heart failure and preserved ejection fraction  Academic Article
• A review of exemestane in the management of breast cancer  Academic Article
• ASymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the atrial fibrillation Reduction atrial pacing Trial (ASSERT)  Academic Article
• Accuracy of Bayley Scores as Outcome Measures in Trials of Neonatal Therapies  Academic Article
• Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials  Academic Article
• Acute myelogenous leukemia in adolescents and young adults  Academic Article
• Adjudicating Outcomes: Fundamentals  Academic Article
• Adjudicating ventilator-associated pneumonia in a randomized trial of critically ill patients  Academic Article
• Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials  Academic Article
• Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis  Academic Article
• Adjuvant/neoadjuvant trastuzumab therapy in women with HER-2/neu-overexpressing breast cancer: A systematic review  Academic Article
• Age of the female partner is a prognostic factor in prolonged unexplained infertility: a multicenter study *†  Academic Article
• Agreement in reporting between trial publications and current clinical trial registry in high impact journals: A methodological review  Academic Article
• Analysis of Regional Timelines To Set Up a Global Phase III Clinical Trial in Breast Cancer: The Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Experience  Academic Article
• Anticoagulant therapy after acute myocardial infarction  Academic Article
• Are large clinical trials in orthopaedic trauma justified?  Academic Article
• Aspirin Versus Low-Molecular-Weight Heparin for Ischemic Stroke in Children: An Unanswered Question  Academic Article
• Association of cyclooxygenase-2 genetic variant with cardiovascular disease  Academic Article
• Association of mitral annular calcification and aortic valve morphology: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study  Academic Article
• Becoming and staying physically active in adolescents with cerebral palsy: protocol of a qualitative study of facilitators and barriers to physical activity  Academic Article
• Bone Turnover Markers as Predictors of Skeletal Complications in Prostate Cancer, Lung Cancer, and Other Solid Tumors  Academic Article
• CANadian Network and Centre for Trials INternationally (CANNeCTIN): A national network for Canadian-led trials in cardiovascular diseases and diabetes mellitus  Academic Article
• Can orthopedic trials change practice?  Academic Article
• Candidemia in patients with diabetes mellitus: epidemiology and predictors of mortality  Academic Article
• Carotid plaque formation and its evaluation with angiography, ultrasound, and MR angiography  Academic Article
• Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections.  Academic Article
• Central statistical monitoring: Detecting fraud in clinical trials  Academic Article
• Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction  Academic Article
• Challenges to complete and useful data sharing  Academic Article
• Choices of Methodology in Pharmacoeconomic Studies  Academic Article
• Choisir un questionnaire de qualité de vie  Academic Article
• Classification and appraisal of the level of clinical evidence of publications from the Canadian Association of Pediatric Surgeons for the past 10 years  Academic Article
• Clinical trial update: National Cancer Institute of Canada  Academic Article
• Cognitive impairment and risk of cardiovascular events and mortality  Academic Article
• Collaborative multicenter trials in Latin America: challenges and opportunities in orthopedic and trauma surgery  Academic Article
• Comparative Therapeutic Studies with Tilavist  Academic Article
• Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study  Academic Article
• Comparison of 12 Risk Stratification Schemes to Predict Stroke in Patients With Nonvalvular Atrial Fibrillation  Academic Article
• Comparison of the Villalta and Ginsberg clinical scales to diagnose the post-thrombotic syndrome: correlation with patient-reported disease burden and venous valvular reflux  Academic Article
• Comparisons of cause of death verification methods and costs in the lipid research clinics program mortality follow-up study  Academic Article
• Conducting economic evaluations alongside multinational clinical trials: Toward a research consensus  Academic Article
• Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials  Academic Article
• Construction of a FRAX® model for the assessment of fracture probability in Canada and implications for treatment  Academic Article
• Coordination of international multicenter studies: governance and administrative structure  Academic Article
• Coronary stenting in diabetic patients: Results from the ROSETTA registry  Academic Article
• Cost Implications of the Use of Ramipril in High-Risk Patients Based on the Heart Outcomes Prevention Evaluation (HOPE) Study  Academic Article
• Cost‐effectiveness analysis of a multinational RCT with a binary measure of effectiveness and an interacting covariate  Academic Article
• Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis  Academic Article
• Cytoreductive nephrectomy in metastatic renal cell carcinoma: the evolving role of surgery in the era of molecular targeted therapy  Academic Article
• Design and Analytic Considerations in Determining the Cost-Effectiveness of Early Intervention in Asthma from a Multinational Clinical Trial  Academic Article
• Design and baseline characteristics of participants in the R esearching cardiovascular E vents with a W eekly IN cretin in D iabetes ( REWIND ) trial on the cardiovascular effects of dulaglutide  Academic Article
• Design and rationale of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial  Academic Article
• Design of the INPULSIS™ trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis  Academic Article
• Diabetes mellitus, a predictor of morbidity and mortality in the studies of left ventricular dysfunction (SOLVD) trials and registry  Academic Article
• Donepezil and rivastigmine in the treatment of Alzheimer's disease: a best-evidence synthesis of the published data on their efficacy and cost-effectiveness  Academic Article
• Economic Evaluation of Rivastigmine in Patients with Parkinson??s Disease Dementia  Academic Article
• Effect of acute angiotensin converting enzyme inhibition on left ventricular filling in patients with congestive heart failure. Relation to right ventricular volumes.  Academic Article
• Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: the DIG study  Academic Article
• Effect of angiotensin-converting enzyme inhibitors in left ventricular dysfunction: results of the studies of left ventricular dysfunction in the context of other similar trials.  Academic Article
• Effect of visceral metastases on the efficacy and safety of everolimus in postmenopausal women with advanced breast cancer: Subgroup analysis from the BOLERO-2 study  Academic Article
• Effectiveness of Dorzolamide–Timolol (COSOPT) in Patients Who Were Treatment Naive for Open-Angle Glaucoma or Ocular Hypertension: The COSOPT First-Line Study  Academic Article
• Efficacy and tolerability of a “suprabioavailable” formulation of fenofibrate in patients with dyslipidemia: a pooled analysis of two open-label trials  Academic Article
• Emergence of the Primary Pediatric Stroke Center  Academic Article
• Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel  Academic Article
• Evaluating the effectiveness of rosuvastatin in preventing the progression of diastolic dysfunction in aortic stenosis: A substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study  Academic Article
• Evaluation of Buspirone as an Antianxiety Agent: Buspirone and Diazepam versus Placebo*  Academic Article
• Evaluation of outcome and cost-effectiveness using an FDG PET-guided approach to management of patients with coronary disease and severe left ventricular dysfunction (PARR-2): rationale, design, and methods  Academic Article
• Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis  Academic Article
• Factors affecting blood pressure responses to diet: The vanguard study  Academic Article
• Favourable outcome in 135 children with juvenile systemic sclerosis: results of a multi‐national survey  Academic Article
• Femoroacetabular Impingement Randomised controlled Trial (FIRST) - a multi-centre randomized controlled trial comparing arthroscopic lavage and arthroscopic osteochondroplasty on patient important outcomes and quality of life in the treatment of young adult (18–50 years) femoroacetabular impingement: a statistical analysis plan  Academic Article
• Fondaparinux vs Enoxaparin for the Prevention of Venous Thromboembolism in Major Orthopedic SurgeryA Meta-analysis of 4 Randomized Double-blind Studies  Academic Article
• Fracture Risk Assessment in Chronic Kidney Disease, Prospective Testing Under Real World Environments (FRACTURE): a prospective study  Academic Article
• Fracture prediction and calibration of a Canadian FRAX® tool: a population-based report from CaMos  Academic Article
• Globally optimal trial design for local decision making  Academic Article
• Haemorrhagic and thromboembolic complications versus intensity of treatment of venous thromboembolism with oral anticoagulants.  Academic Article
• Health-Related Quality of Life at Age 10 Years in Very Low-Birth-WeightChildren With and Without Threshold Retinopathy of Prematurity  Academic Article
• High dose therapy with stem cell support for breast cancer: the jury is still out.  Academic Article
• Hospital Selection for Unit Cost Estimates in Multicentre Economic Evaluations  Academic Article
• Human Papillomavirus Triage of Atypical Squamous Cells of Undetermined Significance: Cost-Effective, But At What Cost?  Academic Article
• Immunosuppressive activity in human in vitro fertilization (IVF) culture supernatants and prediction of the outcome of embryo transfer: A multicenter trial  Academic Article
• Impact of Diabetes on Long-Term Prognosis in Patients With Unstable Angina and Non–Q-Wave Myocardial Infarction  Academic Article
• Implementation of Timeline Reforms Speeds Initiation of National Cancer Institute-Sponsored Trials  Academic Article
• Improving management of patients with acute cough by C-reactive protein point of care testing and communication training (IMPAC3T): study protocol of a cluster randomised controlled trial  Academic Article
• Incidence of Recurrent Thromboembolic and Bleeding Complications Among Patients With Venous Thromboembolism in Relation to Both Malignancy and Achieved International Normalized Ratio: A Retrospective Analysis  Academic Article
• Incidence of venous thromboembolism in patients undergoing thoracotomy for lung cancer  Academic Article
• Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia  Academic Article
• Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients  Academic Article
• Insights into the role of thrombin in the pathogenesis of recurrent ischaemia after acute coronary syndrome  Academic Article
• Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project  Academic Article
• International longitudinal registry of patients with atrial fibrillation at risk of stroke: Global Anticoagulant Registry in the FIELD (GARFIELD)  Academic Article
• Interpreting Geographic Variations in Results of Randomized, Controlled Trials  Academic Article
• Is a Restrictive Transfusion Strategy Safe for Resuscitated and Critically Ill Trauma Patients?  Academic Article
• Launch of the Canadian Neurosurgery Research Collaborative  Academic Article
• Lessons learned from enrollment in the BEST study—A multicenter, randomized trial of group psychosocial support in metastatic breast cancer  Academic Article
• Lessons learned from the DIG trial  Academic Article
• Limiting loss to follow-up in a multicenter randomized trial in orthopedic surgery  Academic Article
• Low-Molecular-Weight Heparin or Oral Anticoagulation for Secondary Prevention of Deep Vein Thrombosis in Cancer Patients  Academic Article
• Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis  Academic Article
• Markers of Bone Metabolism and Survival in Men with Hormone-Refractory Metastatic Prostate Cancer  Academic Article
• Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes  Academic Article
• Meta-analysis of antiarrhythmic drug trials  Academic Article
• Misspecification of Cox regression models with composite endpoints  Academic Article
• Moving forward through consensus: protocol for a modified Delphi approach to determine the top research priorities in the field of orthopaedic oncology  Academic Article
• Multicenter Collaboration in Observational Research: Improving Generalizability and Efficiency  Academic Article
• Multicenter Study of General Anesthesia. I. Design and Patient Demography  Academic Article
• Multicenter Study of General Anesthesia. II. Results  Academic Article
• Multicenter clinical research in adult critical care  Academic Article
• Multistate Analysis of Skeletal Events in Patients with Bone Metastases  Conference Paper
• National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group Report  Academic Article
• NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol  Academic Article
• New Strategies for the Optimal Use of Platelet Transfusions  Academic Article
• Ontario Cancer Research Ethics Board: Lessons Learned From Developing a Multicenter Regional Institutional Review Board  Academic Article
• Outcome assessment for clinical trials: How many adjudicators do we need?  Academic Article
• Overview of the DIG trial  Academic Article
• PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan  Academic Article
• Participating in Multicenter Randomized Controlled Trials: Whatʼs the Relative Value?  Academic Article
• Patterns of Medication Use in Patients With Heart Failure  Academic Article
• Personalized pharmacotherapy in diabetes care using clinical pharmacology data of basal insulin analogues  Academic Article
• Perturbation training to promote safe independent mobility post-stroke: study protocol for a randomized controlled trial  Academic Article
• Pharmacological Actions of Sulodexide  Academic Article
• Physical activity in patients with stable coronary heart disease: an international perspective  Academic Article
• Plasma Matrix Metalloproteinase-9 Level Is Correlated With Left Ventricular Volumes and Ejection Fraction in Patients With Heart Failure  Academic Article
• Positive Effect of Etidronate Therapy Is Maintained After Drug Is Terminated in Patients Using Corticosteroids  Academic Article
• Postmenopausal breast cancer: is the short-term pain worth the long-term gain?  Academic Article
• Potential demographic and baselines variables for risk stratification of high-risk post-myocardial infarction patients in the era of implantable cardioverter-defibrillator — A prognostic indicator  Academic Article
• Practical Understanding of Mean Percent Psoriasis Area and Severity Index Reduction for Biologics  Academic Article
• Predictors of clinical outcome in patients with heparin-induced thrombocytopenia treated with direct thrombin inhibition  Academic Article
• Predictors of treatment response in patients with non-erosive reflux disease  Academic Article
• Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial  Academic Article
• Prevention of venous thromboembolism in medical patients with enoxaparin  Academic Article
• Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futility.  Academic Article
• Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Pro: Futility stopping can speed up the development of effective treatments.  Academic Article
• Pro: “Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation”  Academic Article
• Prognostic factors for skeletal complications from metastatic bone disease in breast cancer  Academic Article
• Prognostic impact of demographic factors and clinical features on the mode of death in high-risk patients after myocardial infarction - A combined analysis from multicenter trials  Academic Article
• Prognostic variables for survival and skeletal complications in patients with multiple myeloma osteolytic bone disease  Academic Article
• Progression to chronic atrial fibrillation after pacing: the Canadian Trial of Physiologic Pacing  Academic Article
• Propensity score matched comparison of subcutaneous and transvenous implantable cardioverter-defibrillator therapy in the SIMPLE and EFFORTLESS studies  Academic Article
• Protecting Human Research Participants: Reading vs Understanding the Consent Form  Academic Article
• Quality of anticoagulation and use of warfarin-interacting medications in long-term care: A chart review  Academic Article
• Randomization and concealment in surgical trials: a comparison between orthopaedic and non-orthopaedic randomized trials  Academic Article
• Randomized Clinical Trials — Removing Unnecessary Obstacles  Academic Article
• Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) Trial: A randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery  Academic Article
• Rationale, design, implementation, and baseline characteristics of patients in the dig trial: A large, simple, long-term trial to evaluate the effect of digitalis on mortality in heart failure  Academic Article
• Re-evaluation of peri-operative cardiac risk (the MET REPAIR study)  Academic Article
• Recommended clinical practices for maximizing peritoneal dialysis clearances.  Academic Article
• Reduction of cardiovascular events and microvascular complications in diabetes with ACE inhibitor treatment: HOPE and MICRO-HOPE  Academic Article
• Reflections 1 Year Into the 21-Center National Institutes of Health–Funded WRIST Study: A Primer on Conducting a Multicenter Clinical Trial  Academic Article
• Relation of baseline characteristics to suppression of ventricular arrhythmias during placebo and active antiarrhythmic therapy in patients after myocardial infarction.  Academic Article
• Relationship Between A1C and Fasting Plasma Glucose in Dysglycemia or Type 2 Diabetes: An analysis of baseline data from the ORIGIN trial  Academic Article
• Relationship Between Perceived and Measured Changes in Walking After Stroke  Academic Article
• Relationship of Activated Partial Thromboplastin Time to Coronary Events and Bleeding in Patients With Acute Coronary Syndromes Who Receive Heparin  Academic Article
• Report From the Ethics Committee for Immunotherapy  Academic Article
• Research ethics board approval for an international thromboprophylaxis trial  Academic Article
• Sharing of Lessons Learned From Multisite Research  Academic Article
• Short-course antimicrobial therapy for paediatric respiratory infections (SAFER): study protocol for a randomized controlled trial  Academic Article
• Solute clearance approach to adequacy of peritoneal dialysis.  Academic Article
• Specific barriers to the conduct of randomized trials  Academic Article
• Standard Surgical Protocol to Treat Elbow Dislocations with Radial Head and Coronoid Fractures  Academic Article
• Statins and Intracerebral Hemorrhage  Academic Article
• Statistical analysis plan for a cluster-randomized crossover trial comparing the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units (the ICU Visits Study)  Academic Article
• Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial  Academic Article
• Strategies to detect abnormal glucose metabolism in people at high risk of cardiovascular disease from the ORIGIN (Outcome Reduction with Initial Glargine Intervention) trial population  Academic Article
• Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP) randomized controlled trial  Academic Article
• Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Early Breast Cancer Trialists' Collaborative Group.  Academic Article
• THE CANADIAN AMERICAN TICLOPIDINE STUDY (CATS) IN THROMBOEMBOLIC STROKE  Academic Article
• Temporal evolution in the management of acute ST elevation myocardial infarction: the seven-year GUSTO experience from canada and the united states. The North American GUSTO-I and GUSTO-III investigators.  Academic Article
• Temporal trends on the risk of arrhythmic vs. non-arrhythmic deaths in high-risk patients after myocardial infarction: a combined analysis from multicentre trials  Academic Article
• The Analysis of Multinational Cost-Effectiveness Data for Reimbursement Decisions  Academic Article
• The CHORUS (Cerivastatin in Heart Outcomes in Renal Disease: Understanding Survival) protocol: a double-blind, placebo-controlled trial in patients with esrd.  Academic Article
• The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Design, organization, and baseline results.  Academic Article
• The Fluid Study Protocol: A Randomized Controlled Study on the Effects of Bioimpedance Analysis and Vitamin D on Left Ventricular Mass in Peritoneal Dialysis Patients  Academic Article
• The Inhaled Steroid Treatment as Regular Therapy in Early Asthma (START) Study  Academic Article
• The Salmeterol Multicenter Asthma Research Trial  Academic Article
• The Tactics of Large Randomized Trials  Academic Article
• The Value of Washers in Cannulated Screw Fixation of Femoral Neck Fractures  Academic Article
• The cost implications of the use of telmisartan or ramipril in patients at high risk for vascular events: the ONTARGET study  Academic Article
• The effects of nocturnal hemodialysis compared to conventional hemodialysis on change in left ventricular mass: Rationale and study design of a randomized controlled pilot study  Academic Article
• The etiology, diagnosis and treatment of thrombotic disorders in newborn infants: A call for international and multi-institutional studies  Academic Article
• The role of the data coordinating center in the DIG trial  Academic Article
• The role of the pharmacy coordinating center in the DIG trial  Academic Article
• The “parallel-cohort RCT”: Novel design aspects and application in the Kids-DOTT trial of pediatric venous thromboembolism  Academic Article
• Thrombosis prophylaxis in the acutely ill medical patient: insights from the prophylaxis in medical patients with enoxaparin (MEDENOX) trial  Academic Article
• Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction  Academic Article
• Treatment strategies in elderly patients with aggressive histology lymphoma.  Academic Article
• Trends in the utilization and wastage of coagulation factor concentrates: the application of a regional tracking programme  Academic Article
• Two-state mixed renewal processes for chronic disease  Academic Article
• Use of the day 6 bone marrow to alter remission induction therapy in patients with acute myeloid leukaemia: a leukemia intergroup study  Academic Article
• Will this trial change my practice? TASTE - a randomised registry on thrombus aspiration in primary PCI with a 30-day endpoint  Academic Article
• Work Productivity and Healthcare Resource Utilization Outcomes for Patients on Etanercept for Moderate-to-Severe Plaque Psoriasis  Academic Article
• [The use of state of the art statistical methodology in biomedical research: the example of methodology for interim analyses in clinical trials].  Academic Article