Multicenter Studies as Topic
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A Challenging Question Regarding the Use of Topical Corticosteroids for Mycosis Fungoides Academic Article
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A Practical Guide to Research: Design, Execution, and Publication Academic Article
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A community-based clinical trial of Intra-Venous zOledRonic acid once Yearly in comparison to oral bisphosphonates in postmenopausal women with osteoporosis: The IVORY trial Academic Article
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A multi-center, pragmatic, effectiveness-implementation (hybrid I) cluster randomized controlled trial to evaluate a child-oriented goal-setting approach in paediatric rehabilitation (the ENGAGE approach): a study protocol Academic Article
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A multinational registry to study the characteristics and outcomes of heart failure patients: The global congestive heart failure (G-CHF) registry Academic Article
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A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis Genetic modifier studies Academic Article
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A phase II clinical and pharmacokinetic study of intravenous exatecan mesylate (DX-8951f) in patients with untreated metastatic gastric cancer Academic Article
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A prediction model for sudden cardiac death in patients with heart failure and preserved ejection fraction Academic Article
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A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol Academic Article
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A review of exemestane in the management of breast cancer Academic Article
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A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial Academic Article
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ASymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the atrial fibrillation Reduction atrial pacing Trial (ASSERT) Academic Article
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Accumulation of Deficits as a Key Risk Factor for Cardiovascular Morbidity and Mortality: A Pooled Analysis of 154 000 Individuals Academic Article
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Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials Academic Article
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Acupuncture treatment for knee osteoarthritis with sensitive points: protocol for a multicentre randomised controlled trial Academic Article
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Acute myelogenous leukemia in adolescents and young adults Academic Article
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Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol Academic Article
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Adjudicating Outcomes: Fundamentals Academic Article
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Adjudicating ventilator-associated pneumonia in a randomized trial of critically ill patients Academic Article
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Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials Academic Article
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Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis Academic Article
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Adjuvant/neoadjuvant trastuzumab therapy in women with HER-2/neu-overexpressing breast cancer: A systematic review Academic Article
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Age of the female partner is a prognostic factor in prolonged unexplained infertility: a multicenter study *† Academic Article
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Agreement in reporting between trial publications and current clinical trial registry in high impact journals: A methodological review Academic Article
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An Innovative Model of Pediatric Emergency Department Mental Health Care: Protocol for a Multicenter Type 1 Effectiveness-Implementation Cluster Randomized Trial Academic Article
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Analysis of Regional Timelines To Set Up a Global Phase III Clinical Trial in Breast Cancer: The Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Experience Academic Article
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Antibiotic Review Kit for Hospitals (ARK-Hospital): study protocol for a stepped-wedge cluster-randomised controlled trial Academic Article
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Anticoagulant therapy after acute myocardial infarction Academic Article
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Antivirals for influenza-Like Illness? A randomised Controlled trial of Clinical and Cost effectiveness in primary CarE (ALIC4E): the ALIC4E protocol Academic Article
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Are large clinical trials in orthopaedic trauma justified? Academic Article
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Aspirin Versus Low-Molecular-Weight Heparin for Ischemic Stroke in Children: An Unanswered Question Academic Article
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Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study Academic Article
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Association of cyclooxygenase-2 genetic variant with cardiovascular disease Academic Article
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Association of mitral annular calcification and aortic valve morphology: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study Academic Article
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At-risk registers integrated into primary care to stop asthma crises in the UK (ARRISA-UK): study protocol for a pragmatic, cluster randomised trial with nested health economic and process evaluations Academic Article
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Becoming and staying physically active in adolescents with cerebral palsy: protocol of a qualitative study of facilitators and barriers to physical activity Academic Article
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Bone Turnover Markers as Predictors of Skeletal Complications in Prostate Cancer, Lung Cancer, and Other Solid Tumors Academic Article
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Burden of Proof for Tolvaptan in ADPKD Academic Article
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Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies Academic Article
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CANadian Network and Centre for Trials INternationally (CANNeCTIN): A national network for Canadian-led trials in cardiovascular diseases and diabetes mellitus Academic Article
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Can orthopedic trials change practice? Academic Article
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Candidemia in patients with diabetes mellitus: epidemiology and predictors of mortality Academic Article
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Cannabinoids and an anti-inflammatory diet for the treatment of neuropathic pain after spinal cord injury (The CATNP Study): study protocol for a randomized controlled trial Academic Article
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Care and outcomes of Canadian children hospitalised with periorbital and orbital cellulitis: protocol for a multicentre, retrospective cohort study Academic Article
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Carotid plaque formation and its evaluation with angiography, ultrasound, and MR angiography Academic Article
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Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections Academic Article
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Central statistical monitoring: Detecting fraud in clinical trials Academic Article
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Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction Academic Article
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Challenges to complete and useful data sharing Academic Article
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Chinese herbal medicine Shenzhuo Formula treatment in patients with macroalbuminuria secondary to diabetic kidney disease: study protocol for a randomized controlled trial Academic Article
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Choices of Methodology in Pharmacoeconomic Studies Academic Article
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Choisir un questionnaire de qualité de vie Academic Article
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Classification and appraisal of the level of clinical evidence of publications from the Canadian Association of Pediatric Surgeons for the past 10 years Academic Article
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Clinical Research: From Case Reports to International Multicenter Clinical Trials Academic Article
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Clinical trial update: National Cancer Institute of Canada Academic Article
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Coached, Coordinated, Enhanced Neonatal Transition (CCENT): protocol for a multicentre pragmatic randomised controlled trial of transition-to-home support for parents of high-risk infants Academic Article
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Cognitive Outcomes after DEXmedetomidine sedation in cardiac surgery: CODEX randomised controlled trial protocol Academic Article
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Cognitive impairment and risk of cardiovascular events and mortality Academic Article
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Collaborative multicenter trials in Latin America: challenges and opportunities in orthopedic and trauma surgery Academic Article
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Combination of first-line chemotherapy with Kanglaite injections versus first-line chemotherapy alone for advanced non-small-cell lung cancer: study protocol for an investigator-initiated, multicenter, open-label, randomized controlled trial Academic Article
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Combined Analysis of Asthma Safety Trials of Long-Acting β2-Agonists Academic Article
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Comment on ‘A multicentre randomized controlled trial of expectant management versus IVF in women with Fallopian tube patency’ Academic Article
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Comparative Therapeutic Studies with Tilavist Academic Article
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Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study Academic Article
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Comparison of 12 Risk Stratification Schemes to Predict Stroke in Patients With Nonvalvular Atrial Fibrillation Academic Article
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Comparisons of cause of death verification methods and costs in the lipid research clinics program mortality follow-up study Academic Article
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Complex care for kids Ontario: protocol for a mixed-methods randomised controlled trial of a population-level care coordination initiative for children with medical complexity Academic Article
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Conducting economic evaluations alongside multinational clinical trials: Toward a research consensus Academic Article
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Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials Academic Article
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Construction of a FRAX® model for the assessment of fracture probability in Canada and implications for treatment Academic Article
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Contrasting evidence to reimbursement reality for off-label use (OLU) of drug treatments in cancer care: rationale and design of the CEIT-OLU project Academic Article
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Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial Academic Article
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Coordination of international multicenter studies: governance and administrative structure Academic Article
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Coronary stenting in diabetic patients: Results from the ROSETTA registry Academic Article
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Cost Implications of the Use of Ramipril in High-Risk Patients Based on the Heart Outcomes Prevention Evaluation (HOPE) Study Academic Article
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Cost‐effectiveness analysis of a multinational RCT with a binary measure of effectiveness and an interacting covariate Academic Article
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Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis Academic Article
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Cytoreductive nephrectomy in metastatic renal cell carcinoma: the evolving role of surgery in the era of molecular targeted therapy Academic Article
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Design and Analytic Considerations in Determining the Cost-Effectiveness of Early Intervention in Asthma from a Multinational Clinical Trial Academic Article
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Design and baseline characteristics of participants in the
R
esearching cardiovascular
E
vents with a
W
eekly
IN
cretin in
D
iabetes (
REWIND
) trial on the cardiovascular effects of dulaglutide Academic Article
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Design and rationale of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial Academic Article
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Design of the INPULSIS™ trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis Academic Article
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Development of a clinical prediction model for the postthrombotic syndrome in a prospective cohort of patients with proximal deep vein thrombosis Academic Article
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Diabetes mellitus, a predictor of morbidity and mortality in the studies of left ventricular dysfunction (SOLVD) trials and registry Academic Article
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Diarrhoea: interventions, consequences and epidemiology in the intensive care unit (DICE-ICU): a protocol for a prospective multicentre cohort study Academic Article
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Donepezil and rivastigmine in the treatment of Alzheimer's disease: a best-evidence synthesis of the published data on their efficacy and cost-effectiveness Academic Article
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Economic Evaluation of Rivastigmine in Patients with Parkinson??s Disease Dementia Academic Article
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Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol Academic Article
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Effect of Angiotensin-Converting Enzyme Inhibitors in Left Ventricular Dysfunction Academic Article
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Effect of acute angiotensin converting enzyme inhibition on left ventricular filling in patients with congestive heart failure. Relation to right ventricular volumes. Academic Article
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Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: the DIG study Academic Article
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Effect of visceral metastases on the efficacy and safety of everolimus in postmenopausal women with advanced breast cancer: Subgroup analysis from the BOLERO-2 study Academic Article
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Effectiveness and safety of Chinese herbal medicine xuanbi antong granules for the treatment of borderline coronary lesions: study protocol for a randomised, double-blinded, placebo-controlled, multicentre clinical trial Academic Article
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Effectiveness of Dorzolamide–Timolol (COSOPT) in Patients Who Were Treatment Naive for Open-Angle Glaucoma or Ocular Hypertension: The COSOPT First-Line Study Academic Article
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Effects of Dronedarone Started Rapidly After Amiodarone Discontinuation Academic Article
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Effects of exercise interventions on cardiovascular health in individuals with chronic, motor complete spinal cord injury: protocol for a randomised controlled trial [Cardiovascular Health/Outcomes: Improvements Created by Exercise and education in SCI (CHOICES) Study] Academic Article
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Efficacy and tolerability of a “suprabioavailable” formulation of fenofibrate in patients with dyslipidemia: a pooled analysis of two open-label trials Academic Article
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El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos Academic Article
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Emergence of the Primary Pediatric Stroke Center Academic Article
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Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel Academic Article
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Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT Academic Article
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Evaluating the effectiveness of rosuvastatin in preventing the progression of diastolic dysfunction in aortic stenosis: A substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study Academic Article
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Evaluation of Buspirone as an Antianxiety Agent: Buspirone and Diazepam versus Placebo* Academic Article
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Evaluation of outcome and cost-effectiveness using an FDG PET-guided approach to management of patients with coronary disease and severe left ventricular dysfunction (PARR-2): rationale, design, and methods Academic Article
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Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis Academic Article
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Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol Academic Article
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Factors affecting blood pressure responses to diet: The vanguard study Academic Article
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Feasibility study protocol of a pragmatic, randomised controlled pilot trial: membrane sweeping to prevent post-term pregnancy—the MILO Study Academic Article
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Femoroacetabular Impingement Randomised controlled Trial (FIRST) - a multi-centre randomized controlled trial comparing arthroscopic lavage and arthroscopic osteochondroplasty on patient important outcomes and quality of life in the treatment of young adult (18–50 years) femoroacetabular impingement: a statistical analysis plan Academic Article
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Fondaparinux vs Enoxaparin for the Prevention of Venous Thromboembolism in Major Orthopedic Surgery<subtitle>A Meta-analysis of 4 Randomized Double-blind Studies</subtitle> Academic Article
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Fracture Risk Assessment in Chronic Kidney Disease, Prospective Testing Under Real World Environments (FRACTURE): a prospective study Academic Article
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Fracture prediction and calibration of a Canadian FRAX® tool: a population-based report from CaMos Academic Article
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Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial Academic Article
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Gemifloxacin versus Amoxicillin/Clavulanate in the Treatment of Acute Exacerbations of Chronic Bronchitis Academic Article
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Generalizability of results from the recent FDA-guided cardiovascular outcomes trials to a representative population with Type 2 Diabetes attending primary care clinics Academic Article
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Globally optimal trial design for local decision making Academic Article
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Haemorrhagic and thromboembolic complications versus intensity of treatment of venous thromboembolism with oral anticoagulants. Academic Article
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Health-Related Quality of Life at Age 10 Years in Very Low-Birth-WeightChildren With and Without Threshold Retinopathy of Prematurity Academic Article
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Hemostatic efficacy of pathogen-inactivated vs untreated platelets: a randomized controlled trial Academic Article
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High Dose Therapy with Stem Cell Support for Breast Cancer: The Jury Is Still Out Academic Article
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High-Sensitivity Cardiac Troponin—Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women (CODE-MI): Rationale and design for a multicenter, stepped-wedge, cluster-randomized trial Academic Article
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Hospital Selection for Unit Cost Estimates in Multicentre Economic Evaluations Academic Article
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How Did We Get Here?: A Historical Review and Critical Analysis of Anticoagulation Therapy Following Mechanical Valve Replacement Academic Article
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Human Papillomavirus Triage of Atypical Squamous Cells of Undetermined Significance: Cost-Effective, But At What Cost? Academic Article
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Immunosuppressive activity in human in vitro fertilization (IVF) culture supernatants and prediction of the outcome of embryo transfer: A multicenter trial Academic Article
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Impact of Diabetes on Long-Term Prognosis in Patients With Unstable Angina and Non–Q-Wave Myocardial Infarction Academic Article
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Implementation of Timeline Reforms Speeds Initiation of National Cancer Institute-Sponsored Trials Academic Article
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Improving management of patients with acute cough by C-reactive protein point of care testing and communication training (IMPAC3T): study protocol of a cluster randomised controlled trial Academic Article
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Incidence of venous thromboembolism in patients undergoing thoracotomy for lung cancer Academic Article
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Incorporating Utility-Based Quality-of-Life Assessment Measures in Clinical Trials Academic Article
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Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia Academic Article
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Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients Academic Article
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Individual Patient Data from the Pivotal Randomized Controlled Trials of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation (COMBINE AF): Design and Rationale Academic Article
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Insights into the role of thrombin in the pathogenesis of recurrent ischaemia after acute coronary syndrome Academic Article
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Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project Academic Article
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International longitudinal registry of patients with atrial fibrillation at risk of stroke: Global Anticoagulant Registry in the FIELD (GARFIELD) Academic Article
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International point prevalence study of Intensive Care Unit transfusion practices—Pilot study in the Netherlands Academic Article
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Interpreting Geographic Variations in Results of Randomized, Controlled Trials Academic Article
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Introducing an innovative model of acute paediatric mental health and addictions care to paediatric emergency departments: a protocol for a multicentre prospective cohort study Academic Article
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Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial Academic Article
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Iron overload in myelodysplastic syndromes: Evidence based guidelines from the Canadian consortium on MDS Academic Article
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Is a Restrictive Transfusion Strategy Safe for Resuscitated and Critically Ill Trauma Patients? Academic Article
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Launch of the Canadian Neurosurgery Research Collaborative Academic Article
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Lessons learned from enrollment in the BEST study—A multicenter, randomized trial of group psychosocial support in metastatic breast cancer Academic Article
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Lessons learned from the DIG trial Academic Article
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Limiting loss to follow-up in a multicenter randomized trial in orthopedic surgery Academic Article
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Long-term outcomes of total elbow arthroplasty for distal humeral fracture: results from a prior randomized clinical trial Academic Article
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Longitudinal Youth in Transition Study (LYiTS): protocol for a multicentre prospective cohort study of youth transitioning out of child and adolescent mental health services at age 18 Academic Article
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Low Adherence to Recommended Guidelines for Open Fracture Antibiotic Prophylaxis Academic Article
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Low-Molecular-Weight Heparin or Oral Anticoagulation for Secondary Prevention of Deep Vein Thrombosis in Cancer Patients Academic Article
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Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis Academic Article
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MUFFIN-PTS trial, Micronized Purified Flavonoid Fraction for the Treatment of Post-Thrombotic Syndrome: protocol of a randomised controlled trial Academic Article
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Markers of Bone Metabolism and Survival in Men with Hormone-Refractory Metastatic Prostate Cancer Academic Article
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Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes Academic Article
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Meta-analysis of antiarrhythmic drug trials Academic Article
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Moving forward through consensus: protocol for a modified Delphi approach to determine the top research priorities in the field of orthopaedic oncology Academic Article
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Multicenter Collaboration in Observational Research: Improving Generalizability and Efficiency Academic Article
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Multicenter Study of General Anesthesia. I. Design and Patient Demography Academic Article
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Multicenter Study of General Anesthesia. II. Results Academic Article
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Multicenter clinical research in adult critical care Academic Article
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Multicentre, single-blind randomised controlled trial comparing MyndMove neuromodulation therapy with conventional therapy in traumatic spinal cord injury: a protocol study Academic Article
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Multistate Analysis of Skeletal Events in Patients with Bone Metastases Conference Paper
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National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group Report Academic Article
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Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials Academic Article
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New Strategies for the Optimal Use of Platelet Transfusions Academic Article
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Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness Academic Article
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Once-Daily Therapy with Ceftriaxone Compared with Daily Multiple-Dose Therapy with Cefotaxime for Serious Bacterial Infections: A Randomized, Double-Blind Study Academic Article
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Ontario Cancer Research Ethics Board: Lessons Learned From Developing a Multicenter Regional Institutional Review Board Academic Article
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Opportunities for enhancing the care of older patients with ST-elevation myocardial infarction presenting for primary percutaneous coronary intervention: Rationale and design of the SAFE-STEMI for Seniors trial Academic Article
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Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery Academic Article
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Our Choice: study protocol for a randomized controlled trial for optimal implementation of psoriasis treatment by the integration of Chinese and western medicine Academic Article
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Outcome assessment for clinical trials: How many adjudicators do we need? Academic Article
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Overview of the DIG trial Academic Article
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POP-Brazil study protocol: a nationwide cross-sectional evaluation of the prevalence and genotype distribution of human papillomavirus (HPV) in Brazil Academic Article
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PREVENTion of CLots in Orthopaedic Trauma (PREVENT CLOT): a randomised
pragmatic trial protocol comparing aspirin versus low-molecular-weight
heparin for blood clot prevention in orthopaedic trauma patients Academic Article
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PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan Academic Article
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Participating in Multicenter Randomized Controlled Trials: What’s the Relative Value? Academic Article
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Patient and caregiver involvement in a multicentre clustered hemodialysis trial Academic Article
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Patient engagement in research related to accelerated surgical care and treatment for hip fracture Academic Article
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Patterns of Medication Use in Patients With Heart Failure Academic Article
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Peri-Operative Eltrombopag or Immune Globulin for Patients with Immune Thrombocytopaenia (The Bridging ITP Trial): Methods and Rationale Academic Article
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Perioperative Troponin Screening Identifies Patients at Higher Risk for Major Cardiovascular Events in Noncardiac Surgery Academic Article
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Perturbation training to promote safe independent mobility post-stroke: study protocol for a randomized controlled trial Academic Article
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Pharmacological Actions of Sulodexide Academic Article
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Physical activity in patients with stable coronary heart disease: an international perspective Academic Article
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Plasma Matrix Metalloproteinase-9 Level Is Correlated With Left Ventricular Volumes and Ejection Fraction in Patients With Heart Failure Academic Article
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Plasma exchange in Canada. The Canadian Apheresis Study Group. Academic Article
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Platelet function testing: does a randomized controlled trial settle the debate? Academic Article
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Pooling Birth Cohorts in Allergy and Asthma: European Union-Funded Initiatives – A MeDALL, CHICOS, ENRIECO, and GA<sup>2</sup>LEN Joint Paper Academic Article
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Positive Effect of Etidronate Therapy Is Maintained After Drug Is Terminated in Patients Using Corticosteroids Academic Article
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Postmenopausal breast cancer: is the short-term pain worth the long-term gain? Academic Article
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Potential demographic and baselines variables for risk stratification of high-risk post-myocardial infarction patients in the era of implantable cardioverter-defibrillator — A prognostic indicator Academic Article
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Practical Understanding of Mean Percent Psoriasis Area and Severity Index Reduction for Biologics Academic Article
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Predicting Malignancy Risk of Screen-Detected Lung Nodules–Mean Diameter or Volume Academic Article
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Predictors of clinical outcome in patients with heparin-induced thrombocytopenia treated with direct thrombin inhibition Academic Article
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Predictors of treatment response in patients with non-erosive reflux disease Academic Article
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Present criteria for prophylactic ICD implantation: Insights from the EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope) project Academic Article
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Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial Academic Article
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Prevention of venous thromboembolism in medical patients with enoxaparin Academic Article
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Primary care-based integrated disease management for heart failure: a study protocol for a cluster randomised controlled trial Academic Article
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Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futility. Academic Article
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Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Pro: Futility stopping can speed up the development of effective treatments. Academic Article
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Pro: “Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation” Academic Article
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Prognostic impact of demographic factors and clinical features on the mode of death in high-risk patients after myocardial infarction - A combined analysis from multicenter trials Academic Article
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Progression to chronic atrial fibrillation after pacing: the Canadian Trial of Physiologic Pacing Academic Article
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Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial Academic Article
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Propensity score matched comparison of subcutaneous and transvenous implantable cardioverter-defibrillator therapy in the SIMPLE and EFFORTLESS studies Academic Article
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Prospective Surveillance for Primary Bloodstream Infections Occurring in Canadian Hemodialysis Units Academic Article
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Prospective, randomized, controlled, double-blind, multi-center, multinational study on the safety and efficacy of 6% Hydroxyethyl starch (HES) sOlution versus an Electrolyte solutioN In patients undergoing eleCtive abdominal Surgery: study protocol for the PHOENICS study Academic Article
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Protecting Human Research Participants: Reading vs Understanding the Consent Form Academic Article
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Protocol for a multicenter prospective cohort study evaluating arthroscopic and non-surgical treatment for microinstability of the hip joint Academic Article
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Protocol for a multicenter prospective cohort study evaluating sport activity and development of femoroacetabular impingement in the adolescent hip Academic Article
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Protocol for a multicenter randomized controlled trial comparing a non-opioid prescription to the standard of care for pain control following arthroscopic knee and shoulder surgery Academic Article
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Protocol for a multicentre, randomised, parallel-control, superiority trial comparing administration of clotting factor concentrates with a standard massive haemorrhage protocol in severely bleeding trauma patients: the FiiRST 2 trial (a 2020 EAST multicentre trial) Academic Article
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Protocol for a randomised trial evaluating a preconception-early childhood telephone-based intervention with tailored e-health resources for women and their partners to optimise growth and development among children in Canada: a Healthy Life Trajectory Initiative (HeLTI Canada) Academic Article
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Quality of anticoagulation and use of warfarin-interacting medications in long-term care: A chart review Academic Article
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Randomization and concealment in surgical trials: a comparison between orthopaedic and non-orthopaedic randomized trials Academic Article
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Randomized Clinical Trials — Removing Unnecessary Obstacles Academic Article
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Rationale and design of ePPOP-ID: a multicenter randomized controlled trial using an electronic-personalized program for obesity in pregnancy to improve delivery Academic Article
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Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) Trial: A randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery Academic Article
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Rationale, design, implementation, and baseline characteristics of patients in the dig trial: A large, simple, long-term trial to evaluate the effect of digitalis on mortality in heart failure Academic Article
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Re-evaluation of peri-operative cardiac risk (the MET REPAIR study) Academic Article
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Recommended Clinical Practices for Maximizing Peritoneal Dialysis Clearances Academic Article
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Reduction of cardiovascular events and microvascular complications in diabetes with ACE inhibitor treatment: HOPE and MICRO-HOPE Academic Article
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Refining risk classification in childhood B acute lymphoblastic leukemia: results of DFCI ALL Consortium Protocol 05-001 Academic Article
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Reflections 1 Year Into the 21-Center National Institutes of Health–Funded WRIST Study: A Primer on Conducting a Multicenter Clinical Trial Academic Article
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Relation of baseline characteristics to suppression of ventricular arrhythmias during placebo and active antiarrhythmic therapy in patients after myocardial infarction. Academic Article
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Relationship Between A1C and Fasting Plasma Glucose in Dysglycemia or Type 2 Diabetes Academic Article
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Relationship Between Perceived and Measured Changes in Walking After Stroke Academic Article
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Relationship of Activated Partial Thromboplastin Time to Coronary Events and Bleeding in Patients With Acute Coronary Syndromes Who Receive Heparin Academic Article
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Remote ischemic conditioning in necrotizing enterocolitis: study protocol of a multi-center phase II feasibility randomized controlled trial Academic Article
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Renal hypothermia during partial nephrectomy for patients with renal tumours: a randomised controlled clinical trial protocol Academic Article
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Report From the Ethics Committee for Immunotherapy Academic Article
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Research ethics board approval for an international thromboprophylaxis trial Academic Article
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Resting state fMRI scanner instabilities revealed by longitudinal phantom scans in a multi-center study Academic Article
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Satisfactory Analgesia with Minimal Emesis in Day Surgeries (SAME DayS): a protocol for a randomised controlled trial of morphine versus hydromorphone Academic Article
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Second Vasovagal Pacemaker Study (VPS II): Rationale, Design, Results, and Implications for Practice and Future Clinical Trials Academic Article
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Sharing of Lessons Learned From Multisite Research Academic Article
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Short-course antimicrobial therapy for paediatric respiratory infections (SAFER): study protocol for a randomized controlled trial Academic Article
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Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies Academic Article
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Solute Clearance Approach to Adequacy of Peritoneal Dialysis Academic Article
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Specific barriers to the conduct of randomized trials Academic Article
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Standard Surgical Protocol to Treat Elbow Dislocations with Radial Head and Coronoid Fractures Academic Article
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Statins and Intracerebral Hemorrhage Academic Article
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Statistical analysis plan for a cluster-randomised trial assessing the effectiveness of implementation of a bedside evidence-based checklist for clinical management of brain-dead potential organ donors in intensive care units: DONORS (Donation Network to Optimise Organ Recovery Study) Academic Article
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Statistical analysis plan for a cluster-randomized crossover trial comparing the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units (the ICU Visits Study) Academic Article
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Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial Academic Article
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Strategies to detect abnormal glucose metabolism in people at high risk of cardiovascular disease from the ORIGIN (Outcome Reduction with Initial Glargine Intervention) trial population Academic Article
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Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP) randomized controlled trial Academic Article
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Studies of Left Ventricular Dysfunction (SOLVD)—Rationale, design and methods: Two trials that evaluate the effect of enalapril in patients with reduced ejection fraction Academic Article
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Study protocol for two complementary trials of non-steroidal or opioid analgesia use for children aged 6 to 17 years with musculoskeletal injuries (the No OUCH study) Academic Article
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Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy Academic Article
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Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy Academic Article
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TB and COVID-19 co-infection: rationale and aims of a global study Academic Article
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THE CANADIAN AMERICAN TICLOPIDINE STUDY (CATS) IN THROMBOEMBOLIC STROKE Academic Article
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Temporal Trends and Factors Associated With the Inclusion of Patient‐Reported Outcomes in Heart Failure Randomized Controlled Trials: A Systematic Review Academic Article
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Temporal evolution in the management of acute ST elevation myocardial infarction: the seven-year GUSTO experience from canada and the united states. The North American GUSTO-I and GUSTO-III investigators. Academic Article
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Temporal trends on the risk of arrhythmic vs. non-arrhythmic deaths in high-risk patients after myocardial infarction: a combined analysis from multicentre trials Academic Article
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The Analysis of Multinational Cost-Effectiveness Data for Reimbursement Decisions Academic Article
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The BEACON study: protocol for a cohort study as part of an evaluation of the effectiveness of smartphone-assisted problem-solving therapy in men who present with intentional self-harm to emergency departments in Ontario Academic Article
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The CHORUS (Cerivastatin in Heart Outcomes in Renal Disease: Understanding Survival) protocol: a double-blind, placebo-controlled trial in patients with esrd. Academic Article
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The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Design, organization, and baseline results. Academic Article
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The Complexity of Conducting a Multicenter Clinical Trial Academic Article
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The Fluid Study Protocol: A Randomized Controlled Study on the Effects of Bioimpedance Analysis and Vitamin D on Left Ventricular Mass in Peritoneal Dialysis Patients Academic Article
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The Inhaled Steroid Treatment as Regular Therapy in Early Asthma (START) Study Academic Article
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The Public Access Defibrillation (PAD) Trial Academic Article
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The Salmeterol Multicenter Asthma Research Trial Academic Article
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The Stability study: a protocol for a multicenter randomized clinical trial comparing anterior cruciate ligament reconstruction with and without Lateral Extra-articular Tenodesis in individuals who are at high risk of graft failure Academic Article
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The Tactics of Large Randomized Trials Academic Article
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The Transitions to Long-term In Home Ventilator Engagement Study (Transitions to LIVE): study protocol for a pragmatic randomized controlled trial Academic Article
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The Value of Washers in Cannulated Screw Fixation of Femoral Neck Fractures Academic Article
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The cost implications of the use of telmisartan or ramipril in patients at high risk for vascular events: the ONTARGET study Academic Article
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The effects of nocturnal hemodialysis compared to conventional hemodialysis on change in left ventricular mass: Rationale and study design of a randomized controlled pilot study Academic Article
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The role of the data coordinating center in the DIG trial Academic Article
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The role of the data coordinating center in the IRB review and approval process: the DIG trial experience Academic Article
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The role of the pharmacy coordinating center in the DIG trial Academic Article
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The “parallel-cohort RCT”: Novel design aspects and application in the Kids-DOTT trial of pediatric venous thromboembolism Academic Article
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Thrombosis prophylaxis in the acutely ill medical patient: insights from the prophylaxis in medical patients with enoxaparin (MEDENOX) trial Academic Article
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Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction Academic Article
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Tocilizumab did not reduce hypoxemic respiratory failure or death in hospitalized patients with COVID-19 Academic Article
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Treatment strategies in elderly patients with aggressive histology lymphoma. Academic Article
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Trends in the utilization and wastage of coagulation factor concentrates: the application of a regional tracking programme Academic Article
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Use of the day 6 bone marrow to alter remission induction therapy in patients with acute myeloid leukaemia: a leukemia intergroup study Academic Article
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Variations between countries in invasive cardiac procedures Academic Article
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Will this trial change my practice? TASTE - a randomised registry on thrombus aspiration in primary PCI with a 30-day endpoint Academic Article
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Work Productivity and Healthcare Resource Utilization Outcomes for Patients on Etanercept for Moderate-to-Severe Plaque Psoriasis Academic Article
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Xylitol for the prevention of acute otitis media episodes in children aged 2–4 years: protocol for a pragmatic randomised controlled trial Academic Article