Multicenter Studies as Topic Concept

subject area of

• A European multicenter randomized controlled trial of single dose surfactant therapy for idiopathic respiratory distress syndrome  Academic Article
• A Multicenter Randomized, Placebo-Controlled Trial of Surfactant Therapy for Respiratory Distress Syndrome  Academic Article
• A Practical Guide to Research: Design, Execution, and Publication  Academic Article
• A community-based clinical trial of Intra-Venous zOledRonic acid once Yearly in comparison to oral bisphosphonates in postmenopausal women with osteoporosis: The IVORY trial  Academic Article
• A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis Genetic modifier studies  Academic Article
• A phase II clinical and pharmacokinetic study of intravenous exatecan mesylate (DX-8951f) in patients with untreated metastatic gastric cancer  Academic Article
• A review of exemestane in the management of breast cancer  Academic Article
• ASymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the atrial fibrillation Reduction atrial pacing Trial (ASSERT)  Academic Article
• Accuracy of Bayley Scores as Outcome Measures in Trials of Neonatal Therapies  Academic Article
• Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials  Academic Article
• Adjudicating Outcomes: Fundamentals  Academic Article
• Adjudicating ventilator-associated pneumonia in a randomized trial of critically ill patients  Academic Article
• Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis  Academic Article
• Age of the female partner is a prognostic factor in prolonged unexplained infertility: a multicenter study *†  Academic Article
• Analysis of Regional Timelines To Set Up a Global Phase III Clinical Trial in Breast Cancer: The Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Experience  Academic Article
• Anticoagulant therapy after acute myocardial infarction  Academic Article
• Aspirin Versus Low-Molecular-Weight Heparin for Ischemic Stroke in Children: An Unanswered Question * Response  Academic Article
• Association of cyclooxygenase-2 genetic variant with cardiovascular disease  Academic Article
• Becoming and staying physically active in adolescents with cerebral palsy: protocol of a qualitative study of facilitators and barriers to physical activity  Academic Article
• Bone Turnover Markers as Predictors of Skeletal Complications in Prostate Cancer, Lung Cancer, and Other Solid Tumors  Academic Article
• CANadian Network and Centre for Trials INternationally (CANNeCTIN): A national network for Canadian-led trials in cardiovascular diseases and diabetes mellitus  Academic Article
• Can orthopedic trials change practice?  Academic Article
• Carotid plaque formation and its evaluation with angiography, ultrasound, and MR angiography  Academic Article
• Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections.  Academic Article
• Central statistical monitoring: Detecting fraud in clinical trials  Academic Article
• Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction  Academic Article
• Challenges to complete and useful data sharing  Academic Article
• Classification and appraisal of the level of clinical evidence of publications from the Canadian Association of Pediatric Surgeons for the past 10 years  Academic Article
• Clinical trial update: National Cancer Institute of Canada  Academic Article
• Cognitive impairment and risk of cardiovascular events and mortality  Academic Article
• Collaborative multicenter trials in Latin America: challenges and opportunities in orthopedic and trauma surgery  Academic Article
• Comparative Therapeutic Studies with Tilavist  Academic Article
• Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study  Academic Article
• Comparison of the Villalta and Ginsberg clinical scales to diagnose the post-thrombotic syndrome: correlation with patient-reported disease burden and venous valvular reflux  Academic Article
• Comparisons of cause of death verification methods and costs in the lipid research clinics program mortality follow-up study  Academic Article
• Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials  Academic Article
• Construction of a FRAX® model for the assessment of fracture probability in Canada and implications for treatment  Academic Article
• Coordination of international multicenter studies: governance and administrative structure  Academic Article
• Coronary stenting in diabetic patients: Results from the ROSETTA registry  Academic Article
• Cost Implications of the Use of Ramipril in High-Risk Patients Based on the Heart Outcomes Prevention Evaluation (HOPE) Study  Academic Article
• Cost‐effectiveness analysis of a multinational RCT with a binary measure of effectiveness and an interacting covariate  Academic Article
• Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis  Academic Article
• Cytoreductive nephrectomy in metastatic renal cell carcinoma: the evolving role of surgery in the era of molecular targeted therapy  Academic Article
• Design and Analytic Considerations in Determining the Cost-Effectiveness of Early Intervention in Asthma from a Multinational Clinical Trial  Academic Article
• Design and baseline characteristics of participants in the Researching cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) trial on the cardiovascular effects of dulaglutide  Academic Article
• Design of the INPULSIS™ trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis  Academic Article
• Diabetes mellitus, a predictor of morbidity and mortality in the studies of left ventricular dysfunction (SOLVD) trials and registry  Academic Article
• Donepezil and rivastigmine in the treatment of Alzheimer's disease: a best-evidence synthesis of the published data on their efficacy and cost-effectiveness  Academic Article
• Economic Evaluation of Rivastigmine in Patients with Parkinson??s Disease Dementia  Academic Article
• Effect of acute angiotensin converting enzyme inhibition on left ventricular filling in patients with congestive heart failure. Relation to right ventricular volumes.  Academic Article
• Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: the DIG study  Academic Article
• Effect of angiotensin-converting enzyme inhibitors in left ventricular dysfunction: results of the studies of left ventricular dysfunction in the context of other similar trials.  Academic Article
• Effect of visceral metastases on the efficacy and safety of everolimus in postmenopausal women with advanced breast cancer: Subgroup analysis from the BOLERO-2 study  Academic Article
• Emergence of the Primary Pediatric Stroke Center: Impact of the Thrombolysis in Pediatric Stroke Trial  Academic Article
• Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel  Academic Article
• Evaluation of outcome and cost-effectiveness using an FDG PET-guided approach to management of patients with coronary disease and severe left ventricular dysfunction (PARR-2): rationale, design, and methods  Academic Article
• Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis  Academic Article
• Factors affecting blood pressure responses to diet: The vanguard study  Academic Article
• Favourable outcome in 135 children with juvenile systemic sclerosis: results of a multi‐national survey  Academic Article
• Fondaparinux vs Enoxaparin for the Prevention of Venous Thromboembolism in Major Orthopedic SurgeryA Meta-analysis of 4 Randomized Double-blind Studies  Academic Article
• Fracture Risk Assessment in Chronic Kidney Disease, Prospective Testing Under Real World Environments (FRACTURE): a prospective study  Academic Article
• Fracture prediction and calibration of a Canadian FRAX® tool: a population-based report from CaMos  Academic Article
• Haemorrhagic and thromboembolic complications versus intensity of treatment of venous thromboembolism with oral anticoagulants.  Academic Article
• Health-Related Quality of Life at Age 10 Years in Very Low-Birth-WeightChildren With and Without Threshold Retinopathy of Prematurity  Academic Article
• High dose therapy with stem cell support for breast cancer: the jury is still out.  Academic Article
• Hospital selection for unit cost estimates in multicentre economic evaluations. Does the choice of hospitals make a difference?  Academic Article
• Human Papillomavirus Triage of Atypical Squamous Cells of Undetermined Significance: Cost-Effective, But At What Cost?  Academic Article
• Immunosuppressive activity in human in vitro fertilization (IVF) culture supernatants and prediction of the outcome of embryo transfer: A multicenter trial  Academic Article
• Impact of Diabetes on Long-Term Prognosis in Patients With Unstable Angina and Non-Q-Wave Myocardial Infarction : Results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry  Academic Article
• Improving management of patients with acute cough by C-reactive protein point of care testing and communication training (IMPAC3T): study protocol of a cluster randomised controlled trial  Academic Article
• Incidence of Recurrent Thromboembolic and Bleeding Complications Among Patients With Venous Thromboembolism in Relation to Both Malignancy and Achieved International Normalized Ratio: A Retrospective Analysis  Academic Article
• Incidence of venous thromboembolism in patients undergoing thoracotomy for lung cancer  Academic Article
• Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia  Academic Article
• Insights into the role of thrombin in the pathogenesis of recurrent ischaemia after acute coronary syndrome  Academic Article
• Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project  Academic Article
• International longitudinal registry of patients with atrial fibrillation at risk of stroke: Global Anticoagulant Registry in the FIELD (GARFIELD)  Academic Article
• Interpreting Geographic Variations in Results of Randomized, Controlled Trials  Academic Article
• Is a Restrictive Transfusion Strategy Safe for Resuscitated and Critically Ill Trauma Patients?  Academic Article
• Lessons learned from enrollment in the BEST study—A multicenter, randomized trial of group psychosocial support in metastatic breast cancer  Academic Article
• Lessons learned from the DIG trial  Academic Article
• Limiting loss to follow-up in a multicenter randomized trial in orthopedic surgery  Academic Article
• Low-Molecular-Weight Heparin or Oral Anticoagulation for Secondary Prevention of Deep Vein Thrombosis in Cancer Patients  Academic Article
• Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis  Academic Article
• Markers of Bone Metabolism and Survival in Men with Hormone-Refractory Metastatic Prostate Cancer  Academic Article
• Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes  Academic Article
• Meta-analysis of antiarrhythmic drug trials  Academic Article
• Misspecification of Cox regression models with composite endpoints  Academic Article
• Moving forward through consensus: protocol for a modified Delphi approach to determine the top research priorities in the field of orthopaedic oncology  Academic Article
• Multicenter Collaboration in Observational Research: Improving Generalizability and Efficiency  Academic Article
• Multicenter Study of General Anesthesia. I. Design and Patient Demography  Academic Article
• Multicenter Study of General Anesthesia. II. Results  Academic Article
• Multicenter clinical research in adult critical care  Academic Article
• Multicenter trial of single-dose modified bovine surfactant extract (Survanta) for prevention of respiratory distress syndrome. Ross Collaborative Surfactant Prevention Study Group.  Academic Article
• Multistate Analysis of Skeletal Events in Patients with Bone Metastases  Conference Paper
• NeOProM: Neonatal Oxygenation Prospective Meta-analysis Collaboration study protocol  Academic Article
• New Strategies for the Optimal Use of Platelet Transfusions  Academic Article
• Ontario Cancer Research Ethics Board: Lessons Learned From Developing a Multicenter Regional Institutional Review Board  Academic Article
• Outcome assessment for clinical trials: How many adjudicators do we need?  Academic Article
• Overview of the DIG trial  Academic Article
• PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan  Academic Article
• Participating in Multicenter Randomized Controlled Trials: Whatʼs the Relative Value?  Academic Article
• Patterns of medication use in patients with heart failure: a report from the Registry of Studies of Left Ventricular Dysfunction (SOLVD).  Academic Article
• Personalized pharmacotherapy in diabetes care using clinical pharmacology data of basal insulin analogues  Academic Article
• Pharmacological Actions of Sulodexide  Academic Article
• Physical activity in patients with stable coronary heart disease: an international perspective  Academic Article
• Plasma Matrix Metalloproteinase-9 Level Is Correlated With Left Ventricular Volumes and Ejection Fraction in Patients With Heart Failure  Academic Article
• Positive Effect of Etidronate Therapy Is Maintained After Drug Is Terminated in Patients Using Corticosteroids  Academic Article
• Postmenopausal breast cancer: is the short-term pain worth the long-term gain?  Academic Article
• Potential demographic and baselines variables for risk stratification of high-risk post-myocardial infarction patients in the era of implantable cardioverter-defibrillator — A prognostic indicator  Academic Article
• Practical Understanding of Mean Percent Psoriasis Area and Severity Index Reduction for Biologics  Academic Article
• Predictors of clinical outcome in patients with heparin-induced thrombocytopenia treated with direct thrombin inhibition  Academic Article
• Predictors of treatment response in patients with non-erosive reflux disease  Academic Article
• Prevention of venous thromboembolism in medical patients with enoxaparin: a subgroup analysis of the MEDENOX study.  Academic Article
• Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futility.  Academic Article
• Pro: “Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation”  Academic Article
• Prognostic impact of demographic factors and clinical features on the mode of death in high-risk patients after myocardial infarction - A combined analysis from multicenter trials  Academic Article
• Progression to chronic atrial fibrillation after pacing: the Canadian Trial of Physiologic Pacing  Academic Article
• Protecting Human Research Participants: Reading vs Understanding the Consent Form  Academic Article
• Quality of anticoagulation and use of warfarin-interacting medications in long-term care: A chart review  Academic Article
• Randomization and concealment in surgical trials: a comparison between orthopaedic and non-orthopaedic randomized trials  Academic Article
• Randomized Clinical Trials — Removing Unnecessary Obstacles  Academic Article
• Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) Trial: A randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery  Academic Article
• Re-evaluation of peri-operative cardiac risk (the MET REPAIR study): Study protocol of a prospective, multicentre cohort study sponsored by the European Society of Anaesthesiology.  Academic Article
• Recommended clinical practices for maximizing peritoneal dialysis clearances.  Academic Article
• Reduction of cardiovascular events and microvascular complications in diabetes with ACE inhibitor treatment: HOPE and MICRO-HOPE  Academic Article
• Regional pathologies and globalization of clinical trials: has the time for regional trials arrived?  Academic Article
• Relation of baseline characteristics to suppression of ventricular arrhythmias during placebo and active antiarrhythmic therapy in patients after myocardial infarction  Academic Article
• Relationship Between A1C and Fasting Plasma Glucose in Dysglycemia or Type 2 Diabetes: An analysis of baseline data from the ORIGIN trial  Academic Article
• Relationship Between Perceived and Measured Changes in Walking After Stroke  Academic Article
• Relationship of Activated Partial Thromboplastin Time to Coronary Events and Bleeding in Patients With Acute Coronary Syndromes Who Receive Heparin  Academic Article
• Report From the Ethics Committee for Immunotherapy  Academic Article
• Research ethics board approval for an international thromboprophylaxis trial  Academic Article
• Solute clearance approach to adequacy of peritoneal dialysis.  Academic Article
• Specific barriers to the conduct of randomized trials  Academic Article
• Standard Surgical Protocol to Treat Elbow Dislocations with Radial Head and Coronoid Fractures  Academic Article
• Statins and intracerebral hemorrhage: a retrospective cohort study.  Academic Article
• Strategies to detect abnormal glucose metabolism in people at high risk of cardiovascular disease from the ORIGIN (Outcome Reduction with Initial Glargine Intervention) trial population  Academic Article
• THE CANADIAN AMERICAN TICLOPIDINE STUDY (CATS) IN THROMBOEMBOLIC STROKE  Academic Article
• Temporal evolution in the management of acute ST elevation myocardial infarction: the seven-year GUSTO experience from canada and the united states. The North American GUSTO-I and GUSTO-III investigators.  Academic Article
• Temporal trends on the risk of arrhythmic vs. non-arrhythmic deaths in high-risk patients after myocardial infarction: a combined analysis from multicentre trials  Academic Article
• The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Design, organization, and baseline results  Academic Article
• The Fluid Study Protocol: A Randomized Controlled Study on the Effects of Bioimpedance Analysis and Vitamin D on Left Ventricular Mass in Peritoneal Dialysis Patients  Academic Article
• The Tactics of Large Randomized Trials  Academic Article
• The Value of Washers in Cannulated Screw Fixation of Femoral Neck Fractures  Academic Article
• The analysis of multinational cost-effectiveness data for reimbursement decisions: a critical appraisal of recent methodological developments.  Academic Article
• The cost implications of the use of telmisartan or ramipril in patients at high risk for vascular events: the ONTARGET study  Academic Article
• The effects of nocturnal hemodialysis compared to conventional hemodialysis on change in left ventricular mass: Rationale and study design of a randomized controlled pilot study  Academic Article
• The etiology, diagnosis and treatment of thrombotic disorders in newborn infants: A call for international and multi-institutional studies  Academic Article
• The inhaled Steroid Treatment as Regular Therapy in early asthma (START) study: rationale and design.  Academic Article
• The role of the data coordinating center in the DIG trial  Academic Article
• The role of the pharmacy coordinating center in the DIG trial  Academic Article
• The “parallel-cohort RCT”: Novel design aspects and application in the Kids-DOTT trial of pediatric venous thromboembolism  Academic Article
• Thrombosis prophylaxis in the acutely ill medical patient: insights from the prophylaxis in medical patients with enoxaparin (MEDENOX) trial  Academic Article
• Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction  Academic Article
• Treatment strategies in elderly patients with aggressive histology lymphoma.  Academic Article
• Trends in the utilization and wastage of coagulation factor concentrates: the application of a regional tracking programme  Academic Article
• Two-state mixed renewal processes for chronic disease  Academic Article
• Use of the day 6 bone marrow to alter remission induction therapy in patients with acute myeloid leukaemia: a leukemia intergroup study  Academic Article
• Will this trial change my practice? TASTE - a randomised registry on thrombus aspiration in primary PCI with a 30-day endpoint  Academic Article
• Work productivity and healthcare resource utilization outcomes for patients on etanercept for moderate-to-severe plaque psoriasis: results from a 1-year, multicentre, open-label, single-arm study in a clinical setting.  Academic Article
• [Beta-blockers in patients undergoing noncardiac surgery: implications of the POISE study].  Academic Article
• [Choosing a quality-of-life questionnaire].  Academic Article
• [The use of state of the art statistical methodology in biomedical research: the example of methodology for interim analyses in clinical trials].  Academic Article
• [Updating in prevention and treatment of prostate cancer].  Academic Article