Multicenter Studies as Topic
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Critical Care Cycling to ImproveLowerExtremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ventilated patients Journal Articles
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A Challenging Question Regarding the Use of Topical Corticosteroids for Mycosis Fungoides Journal Articles
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A Practical Guide to Research: Design, Execution, and Publication Journal Articles
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A Prediction Model for Sudden Cardiac Death in Patients With Heart Failure and Preserved Ejection Fraction Conferences
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A community-based clinical trial of Intra-Venous zOledRonic acid once Yearly in comparison to oral bisphosphonates in postmenopausal women with osteoporosis: The IVORY trial Journal Articles
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A multi-center, pragmatic, effectiveness-implementation (hybrid I) cluster randomized controlled trial to evaluate a child-oriented goal-setting approach in paediatric rehabilitation (the ENGAGE approach): a study protocol Journal Articles
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A multinational registry to study the characteristics and outcomes of heart failure patients: The global congestive heart failure (G-CHF) registry Journal Articles
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A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis Genetic modifier studies Journal Articles
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A phase II clinical and pharmacokinetic study of intravenous exatecan mesylate (DX-8951f) in patients with untreated metastatic gastric cancer Journal Articles
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A prediction model for sudden cardiac death in patients with heart failure and preserved ejection fraction Journal Articles
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A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol Journal Articles
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A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial Journal Articles
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A trial of the Actiderm dermatological patch and topical corticosteroids in the treatment of psoriasis vulgaris. The Actiderm Multi-Center Study Group. Journal Articles
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A trial platform to assess approved SARS-CoV-2 vaccines in immunocompromised patients: first sub-protocol for a pilot trial comparing the mRNA vaccines Comirnaty® and COVID-19 mRNA Vaccine Moderna® Journal Articles
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ASymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the atrial fibrillation Reduction atrial pacing Trial (ASSERT) Journal Articles
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Accumulation of Deficits as a Key Risk Factor for Cardiovascular Morbidity and Mortality: A Pooled Analysis of 154 000 Individuals Journal Articles
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Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials Journal Articles
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Acupuncture treatment for knee osteoarthritis with sensitive points: protocol for a multicentre randomised controlled trial Journal Articles
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Acute myelogenous leukemia in adolescents and young adults Journal Articles
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Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol Journal Articles
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Adjudicating Outcomes: Fundamentals Journal Articles
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Adjudicating ventilator-associated pneumonia in a randomized trial of critically ill patients Journal Articles
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Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis Journal Articles
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Age of the female partner is a prognostic factor in prolonged unexplained infertility: a multicenter study Journal Articles
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Agreement in reporting between trial publications and current clinical trial registry in high impact journals: A methodological review Journal Articles
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An Analysis of the Impact of Timing and Technique on Outcomes after Surgery for Distal Radius Fractures: The Wrist and Radius Injury Surgical Trial Collaborative Study Journal Articles
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An Innovative Model of Pediatric Emergency Department Mental Health Care: Protocol for a Multicenter Type 1 Effectiveness-Implementation Cluster Randomized Trial Journal Articles
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Antibiotic Review Kit for Hospitals (ARK-Hospital): study protocol for a stepped-wedge cluster-randomised controlled trial Journal Articles
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Antibiotic prophylaxis for corneal abrasion Journal Articles
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Anticoagulant therapy after acute myocardial infarction Journal Articles
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Antivirals for influenza-Like Illness? A randomised Controlled trial of Clinical and Cost effectiveness in primary CarE (ALIC4E): the ALIC4E protocol Journal Articles
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Are large clinical trials in orthopaedic trauma justified? Journal Articles
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Aspirin Versus Low-Molecular-Weight Heparin for Ischemic Stroke in Children: An Unanswered Question Journal Articles
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Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study Journal Articles
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Association of cyclooxygenase-2 genetic variant with cardiovascular disease Journal Articles
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Association of mitral annular calcification and aortic valve morphology: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study Journal Articles
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At-risk registers integrated into primary care to stop asthma crises in the UK (ARRISA-UK): study protocol for a pragmatic, cluster randomised trial with nested health economic and process evaluations Journal Articles
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Becoming and staying physically active in adolescents with cerebral palsy: protocol of a qualitative study of facilitators and barriers to physical activity Journal Articles
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Bone Turnover Markers as Predictors of Skeletal Complications in Prostate Cancer, Lung Cancer, and Other Solid Tumors Journal Articles
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Burden of Proof for Tolvaptan in ADPKD Journal Articles
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Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies Journal Articles
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CANadian Network and Centre for Trials INternationally (CANNeCTIN): A national network for Canadian-led trials in cardiovascular diseases and diabetes mellitus Journal Articles
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Can orthopedic trials change practice? Journal Articles
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Canadian Anaphylaxis Network-Predicting Recurrence after Emergency Presentation for Allergic REaction (CAN-PREPARE): a prospective, cohort study protocol Journal Articles
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Candidemia in patients with diabetes mellitus: epidemiology and predictors of mortality Journal Articles
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Cannabinoids and an anti-inflammatory diet for the treatment of neuropathic pain after spinal cord injury (The CATNP Study): study protocol for a randomized controlled trial Journal Articles
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Care and outcomes of Canadian children hospitalised with periorbital and orbital cellulitis: protocol for a multicentre, retrospective cohort study Journal Articles
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Carotid plaque formation and its evaluation with angiography, ultrasound, and MR angiography Journal Articles
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Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections Journal Articles
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Central statistical monitoring: Detecting fraud in clinical trials Journal Articles
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Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction Journal Articles
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Challenges to complete and useful data sharing Journal Articles
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Chinese herbal medicine Shenzhuo Formula treatment in patients with macroalbuminuria secondary to diabetic kidney disease: study protocol for a randomized controlled trial Journal Articles
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Choices of Methodology in Pharmacoeconomic Studies Journal Articles
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Choisir un questionnaire de qualité de vie Journal Articles
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Classification and appraisal of the level of clinical evidence of publications from the Canadian Association of Pediatric Surgeons for the past 10 years Journal Articles
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Clinical Research: From Case Reports to International Multicenter Clinical Trials Journal Articles
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Clinical trial update: National Cancer Institute of Canada Journal Articles
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Coached, Coordinated, Enhanced Neonatal Transition (CCENT): protocol for a multicentre pragmatic randomised controlled trial of transition-to-home support for parents of high-risk infants Journal Articles
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Cognitive Behavioural Therapy to Optimize Post-Operative Fracture Recovery (COPE): protocol for a randomized controlled trial Journal Articles
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Cognitive Outcomes after DEXmedetomidine sedation in cardiac surgery: CODEX randomised controlled trial protocol Journal Articles
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Cognitive impairment and risk of cardiovascular events and mortality Journal Articles
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Collaborative multicenter trials in Latin America: challenges and opportunities in orthopedic and trauma surgery Journal Articles
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Combination of first-line chemotherapy with Kanglaite injections versus first-line chemotherapy alone for advanced non-small-cell lung cancer: study protocol for an investigator-initiated, multicenter, open-label, randomized controlled trial Journal Articles
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Combined Analysis of Asthma Safety Trials of Long-Acting β2-Agonists Journal Articles
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Comment on ‘A multicentre randomized controlled trial of expectant management versus IVF in women with Fallopian tube patency’ Journal Articles
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Comparative Therapeutic Studies with Tilavist Journal Articles
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Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study Journal Articles
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Comparison of 12 Risk Stratification Schemes to Predict Stroke in Patients With Nonvalvular Atrial Fibrillation Journal Articles
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Comparisons of cause of death verification methods and costs in the lipid research clinics program mortality follow-up study Journal Articles
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Complex care for kids Ontario: protocol for a mixed-methods randomised controlled trial of a population-level care coordination initiative for children with medical complexity Journal Articles
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Conducting economic evaluations alongside multinational clinical trials: Toward a research consensus Journal Articles
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Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials Journal Articles
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Construction of a FRAX® model for the assessment of fracture probability in Canada and implications for treatment Journal Articles
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Contrasting evidence to reimbursement reality for off-label use (OLU) of drug treatments in cancer care: rationale and design of the CEIT-OLU project Journal Articles
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Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial Journal Articles
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Coordination of international multicenter studies: governance and administrative structure Journal Articles
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Coronary stenting in diabetic patients: Results from the ROSETTA registry Journal Articles
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Cost Implications of the Use of Ramipril in High-Risk Patients Based on the Heart Outcomes Prevention Evaluation (HOPE) Study Journal Articles
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Cost‐effectiveness analysis of a multinational RCT with a binary measure of effectiveness and an interacting covariate Journal Articles
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Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis Journal Articles
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Design and Analytic Considerations in Determining the Cost-Effectiveness of Early Intervention in Asthma from a Multinational Clinical Trial Journal Articles
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Design and baseline characteristics of participants in the Researching cardiovascular Events with a Weekly INcretin in Diabetes (REWIND) trial on the cardiovascular effects of dulaglutide Journal Articles
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Design and rationale of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial Journal Articles
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Design of the INPULSIS™ trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis Journal Articles
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Development of a clinical prediction model for the postthrombotic syndrome in a prospective cohort of patients with proximal deep vein thrombosis Journal Articles
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Diabetes mellitus, a predictor of morbidity and mortality in the studies of left ventricular dysfunction (SOLVD) trials and registry Journal Articles
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Diarrhoea: interventions, consequences and epidemiology in the intensive care unit (DICE-ICU): a protocol for a prospective multicentre cohort study Journal Articles
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Doppler identified venous congestion in septic shock: protocol for an international, multi-centre prospective cohort study (Andromeda-VEXUS) Journal Articles
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Economic Evaluation of Rivastigmine in Patients with Parkinson??s Disease Dementia Journal Articles
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Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol Journal Articles
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Effect of Angiotensin-Converting Enzyme Inhibitors in Left Ventricular Dysfunction Journal Articles
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Effect of acute angiotensin converting enzyme inhibition on left ventricular filling in patients with congestive heart failure. Relation to right ventricular volumes. Journal Articles
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Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: the DIG study Journal Articles
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Effectiveness and safety of Chinese herbal medicine xuanbi antong granules for the treatment of borderline coronary lesions: study protocol for a randomised, double-blinded, placebo-controlled, multicentre clinical trial Journal Articles
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Effectiveness of Dorzolamide–Timolol (COSOPT) in Patients Who Were Treatment Naive for Open-Angle Glaucoma or Ocular Hypertension: The COSOPT First-Line Study Journal Articles
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Effects of Dronedarone Started Rapidly After Amiodarone Discontinuation Journal Articles
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Effects of exercise interventions on cardiovascular health in individuals with chronic, motor complete spinal cord injury: protocol for a randomised controlled trial [Cardiovascular Health/Outcomes: Improvements Created by Exercise and education in SCI (CHOICES) Study] Journal Articles
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Effects on Mortality and Major Bleeding of Radial Versus Femoral Artery Access for Coronary Angiography or Percutaneous Coronary Intervention: Meta-Analysis of Individual Patient Data From 7 Multicenter Randomized Clinical Trials Journal Articles
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Efficacy of cholesterol-lowering therapy in 18 686 people with diabetes in 14 randomised trials of statins: a meta-analysis Journal Articles
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El uso de metodología estadística actualizada en la investigación biomédica: el ejemplo de metodología para análisis interino en ensayos clínicos Journal Articles
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Emergence of the Primary Pediatric Stroke Center Journal Articles
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Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel Journal Articles
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Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT Journal Articles
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Evaluating the effectiveness of rosuvastatin in preventing the progression of diastolic dysfunction in aortic stenosis: A substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study Journal Articles
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Evaluation of outcome and cost-effectiveness using an FDG PET-guided approach to management of patients with coronary disease and severe left ventricular dysfunction (PARR-2): rationale, design, and methods Journal Articles
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Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis Journal Articles
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Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol Journal Articles
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Factors affecting blood pressure responses to diet: The vanguard study Journal Articles
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Feasibility study protocol of a pragmatic, randomised controlled pilot trial: membrane sweeping to prevent post-term pregnancy—the MILO Study Journal Articles
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Femoroacetabular Impingement Randomised controlled Trial (FIRST) - a multi-centre randomized controlled trial comparing arthroscopic lavage and arthroscopic osteochondroplasty on patient important outcomes and quality of life in the treatment of young adult (18–50 years) femoroacetabular impingement: a statistical analysis plan Journal Articles
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Fondaparinux vs Enoxaparin for the Prevention of Venous Thromboembolism in Major Orthopedic Surgery<subtitle>A Meta-analysis of 4 Randomized Double-blind Studies</subtitle> Journal Articles
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Fracture prediction and calibration of a Canadian FRAX® tool: a population-based report from CaMos Journal Articles
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Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial Journal Articles
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Frequency of screening and SBT Technique Trial—North American Weaning Collaboration (FAST-NAWC): an update to the protocol and statistical analysis plan Journal Articles
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Gemifloxacin versus Amoxicillin/Clavulanate in the Treatment of Acute Exacerbations of Chronic Bronchitis Journal Articles
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Generalizability of results from the recent FDA-guided cardiovascular outcomes trials to a representative population with Type 2 Diabetes attending primary care clinics Journal Articles
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Globally optimal trial design for local decision making Journal Articles
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Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol Journal Articles
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Haemorrhagic and Thromboembolic Complications versus Intensity of Treatment of Venous Thromboembolism with Oral Anticoagulants Journal Articles
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Haemorrhagic and thromboembolic complications versus intensity of treatment of venous thromboembolism with oral anticoagulants. Journal Articles
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Health-Related Quality of Life at Age 10 Years in Very Low-Birth-WeightChildren With and Without Threshold Retinopathy of Prematurity Journal Articles
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Hemostatic efficacy of pathogen-inactivated vs untreated platelets: a randomized controlled trial Journal Articles
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High continuous positive airway pressures versus non-invasive positive pressure ventilation in preterm neonates: protocol for a multicentre pilot randomised controlled trial Journal Articles
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High-Sensitivity Cardiac Troponin—Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women (CODE-MI): Rationale and design for a multicenter, stepped-wedge, cluster-randomized trial Journal Articles
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Hospital Selection for Unit Cost Estimates in Multicentre Economic Evaluations Journal Articles
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How Did We Get Here?: A Historical Review and Critical Analysis of Anticoagulation Therapy Following Mechanical Valve Replacement Journal Articles
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Human Papillomavirus Triage of Atypical Squamous Cells of Undetermined Significance: Cost-Effective, But At What Cost? Journal Articles
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Immunosuppressive activity in human in vitro fertilization (IVF) culture supernatants and prediction of the outcome of embryo transfer: A multicenter trial Journal Articles
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Impact of Diabetes on Long-Term Prognosis in Patients With Unstable Angina and Non–Q-Wave Myocardial Infarction Journal Articles
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Implementation of Timeline Reforms Speeds Initiation of National Cancer Institute-Sponsored Trials Journal Articles
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Improving management of patients with acute cough by C-reactive protein point of care testing and communication training (IMPAC3T): study protocol of a cluster randomised controlled trial Journal Articles
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Incidence of venous thromboembolism in patients undergoing thoracotomy for lung cancer Journal Articles
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Incorporating Utility-Based Quality-of-Life Assessment Measures in Clinical Trials Journal Articles
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Increased cardiovascular risk after pre‐eclampsia in women with dysglycaemia Journal Articles
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Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients Journal Articles
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Individual Participant Data Meta-Analysis of LR-5 in LI-RADS Version 2018 versus Revised LI-RADS for Hepatocellular Carcinoma Diagnosis Journal Articles
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Individual Patient Data from the Pivotal Randomized Controlled Trials of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation (COMBINE AF): Design and Rationale Journal Articles
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Insights into the role of thrombin in the pathogenesis of recurrent ischaemia after acute coronary syndrome Journal Articles
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Inter-institutional data-driven education research: consensus values, principles, and recommendations to guide the ethical sharing of administrative education data in the Canadian medical education research context Journal Articles
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Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project Journal Articles
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International longitudinal registry of patients with atrial fibrillation at risk of stroke: Global Anticoagulant Registry in the FIELD (GARFIELD) Journal Articles
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International point prevalence study of Intensive Care Unit transfusion practices—Pilot study in the Netherlands Journal Articles
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Interpreting Geographic Variations in Results of Randomized, Controlled Trials Journal Articles
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Intravenous acetaminophen for postoperative pain in the neonatal intensive care unit: A protocol for a pilot randomized controlled trial (IVA POP) Journal Articles
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Introducing an innovative model of acute paediatric mental health and addictions care to paediatric emergency departments: a protocol for a multicentre prospective cohort study Journal Articles
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Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial Journal Articles
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Iron overload in myelodysplastic syndromes: Evidence based guidelines from the Canadian consortium on MDS Journal Articles
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Is a Restrictive Transfusion Strategy Safe for Resuscitated and Critically Ill Trauma Patients? Journal Articles
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Launch of the Canadian Neurosurgery Research Collaborative Journal Articles
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Lessons from a multicenter, international, large sample size analysis of patients with obsessive–compulsive disorders: an overview of the ICOCS Snapshot studies Journal Articles
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Lessons learned from enrollment in the BEST study—A multicenter, randomized trial of group psychosocial support in metastatic breast cancer Journal Articles
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Lessons learned from the DIG trial Journal Articles
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Limiting loss to follow-up in a multicenter randomized trial in orthopedic surgery Journal Articles
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Long-term outcomes of total elbow arthroplasty for distal humeral fracture: results from a prior randomized clinical trial Journal Articles
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Longitudinal Youth in Transition Study (LYiTS): protocol for a multicentre prospective cohort study of youth transitioning out of child and adolescent mental health services at age 18 Journal Articles
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Low Adherence to Recommended Guidelines for Open Fracture Antibiotic Prophylaxis Journal Articles
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Low-Molecular-Weight Heparin or Oral Anticoagulation for Secondary Prevention of Deep Vein Thrombosis in Cancer Patients Journal Articles
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Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis Journal Articles
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MUFFIN-PTS trial, Micronized Purified Flavonoid Fraction for the Treatment of Post-Thrombotic Syndrome: protocol of a randomised controlled trial Journal Articles
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Markers of Bone Metabolism and Survival in Men with Hormone-Refractory Metastatic Prostate Cancer Journal Articles
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Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes Journal Articles
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Meta-analysis of antiarrhythmic drug trials Journal Articles
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Monitoring and auditing protocol adherence, data integrity and ethical conduct of a randomized clinical trial: A case study Journal Articles
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Moving forward through consensus: protocol for a modified Delphi approach to determine the top research priorities in the field of orthopaedic oncology Journal Articles
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Multicenter Collaboration in Observational Research: Improving Generalizability and Efficiency Journal Articles
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Multicenter Study of General Anesthesia. I. Design and Patient Demography Journal Articles
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Multicenter Study of General Anesthesia. II. Results Journal Articles
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Multicenter clinical research in adult critical care Journal Articles
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Multicentre, single-blind randomised controlled trial comparing MyndMove neuromodulation therapy with conventional therapy in traumatic spinal cord injury: a protocol study Journal Articles
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Multistate Analysis of Skeletal Events in Patients with Bone Metastases Conferences
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National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group Report Journal Articles
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Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials Journal Articles
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Neurologic Physiology after Removal of Therapy (NeuPaRT) study: study protocol of a multicentre, prospective, observational, pilot feasibility study of neurophysiology after withdrawal of life-sustaining measures Journal Articles
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New Strategies for the Optimal Use of Platelet Transfusions Journal Articles
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Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness Journal Articles
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Once-Daily Therapy with Ceftriaxone Compared with Daily Multiple-Dose Therapy with Cefotaxime for Serious Bacterial Infections: A Randomized, Double-Blind Study Journal Articles
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Ontario Cancer Research Ethics Board: Lessons Learned From Developing a Multicenter Regional Institutional Review Board Journal Articles
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Opportunities for enhancing the care of older patients with ST-elevation myocardial infarction presenting for primary percutaneous coronary intervention: Rationale and design of the SAFE-STEMI for Seniors trial Journal Articles
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Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery Journal Articles
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Our Choice: study protocol for a randomized controlled trial for optimal implementation of psoriasis treatment by the integration of Chinese and western medicine Journal Articles
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Outcome assessment for clinical trials: How many adjudicators do we need? Journal Articles
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Overview of the DIG trial Journal Articles
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POP-Brazil study protocol: a nationwide cross-sectional evaluation of the prevalence and genotype distribution of human papillomavirus (HPV) in Brazil Journal Articles
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PREVENTion of CLots in Orthopaedic Trauma (PREVENT CLOT): a randomised
pragmatic trial protocol comparing aspirin versus low-molecular-weight
heparin for blood clot prevention in orthopaedic trauma patients Journal Articles
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PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan Journal Articles
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Participating in Multicenter Randomized Controlled Trials: What’s the Relative Value? Journal Articles
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Patient and caregiver involvement in a multicentre clustered hemodialysis trial Journal Articles
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Patient engagement in research related to accelerated surgical care and treatment for hip fracture Journal Articles
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Patterns of Medication Use in Patients With Heart Failure Journal Articles
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Penicillin allergy status and its effect on antibiotic prescribing, patient outcomes and antimicrobial resistance (ALABAMA): protocol for a multicentre, parallel-arm, open-label, randomised pragmatic trial Journal Articles
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Peri-Operative Eltrombopag or Immune Globulin for Patients with Immune Thrombocytopaenia (The Bridging ITP Trial): Methods and Rationale Journal Articles
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Perioperative Troponin Screening Identifies Patients at Higher Risk for Major Cardiovascular Events in Noncardiac Surgery Journal Articles
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Perturbation training to promote safe independent mobility post-stroke: study protocol for a randomized controlled trial Journal Articles
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Pharmacological Actions of Sulodexide Journal Articles
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Physical activity in patients with stable coronary heart disease: an international perspective Journal Articles
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Plasma Matrix Metalloproteinase-9 Level Is Correlated With Left Ventricular Volumes and Ejection Fraction in Patients With Heart Failure Journal Articles
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Plasma exchange in Canada. The Canadian Apheresis Study Group. Journal Articles
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Platelet function testing: does a randomized controlled trial settle the debate? Journal Articles
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Pooling Birth Cohorts in Allergy and Asthma: European Union-Funded Initiatives – A MeDALL, CHICOS, ENRIECO, and GA2LEN Joint Paper Journal Articles
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Positive Effect of Etidronate Therapy Is Maintained After Drug Is Terminated in Patients Using Corticosteroids Journal Articles
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Potential demographic and baselines variables for risk stratification of high-risk post-myocardial infarction patients in the era of implantable cardioverter-defibrillator — A prognostic indicator Journal Articles
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Practical Understanding of Mean Percent Psoriasis Area and Severity Index Reduction for Biologics Journal Articles
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Predicting Malignancy Risk of Screen-Detected Lung Nodules–Mean Diameter or Volume Journal Articles
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Predictors of clinical outcome in patients with heparin-induced thrombocytopenia treated with direct thrombin inhibition Journal Articles
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Predictors of treatment response in patients with non‐erosive reflux disease Journal Articles
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Present criteria for prophylactic ICD implantation: Insights from the EU-CERT-ICD (Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in EUrope) project Journal Articles
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Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial Journal Articles
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Prevention of venous thromboembolism in medical patients with enoxaparin Journal Articles
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Primary care-based integrated disease management for heart failure: a study protocol for a cluster randomised controlled trial Journal Articles
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Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futility. Journal Articles
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Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Pro: Futility stopping can speed up the development of effective treatments. Journal Articles
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Pro: “Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation” Journal Articles
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Prognostic factors and outcomes of COVID-19 cases in Ethiopia: multi-center cohort study protocol Journal Articles
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Prognostic impact of demographic factors and clinical features on the mode of death in high-risk patients after myocardial infarction - A combined analysis from multicenter trials Journal Articles
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Progression to chronic atrial fibrillation after pacing: the Canadian Trial of Physiologic Pacing Journal Articles
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Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial Journal Articles
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Propensity score matched comparison of subcutaneous and transvenous implantable cardioverter-defibrillator therapy in the SIMPLE and EFFORTLESS studies Journal Articles
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Prospective Surveillance for Primary Bloodstream Infections Occurring in Canadian Hemodialysis Units Journal Articles
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Prospective, randomized, controlled, double-blind, multi-center, multinational study on the safety and efficacy of 6% Hydroxyethyl starch (HES) sOlution versus an Electrolyte solutioN In patients undergoing eleCtive abdominal Surgery: study protocol for the PHOENICS study Journal Articles
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Protocol for a multicenter prospective cohort study evaluating arthroscopic and non-surgical treatment for microinstability of the hip joint Journal Articles
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Protocol for a multicenter prospective cohort study evaluating sport activity and development of femoroacetabular impingement in the adolescent hip Journal Articles
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Protocol for a multicenter randomized controlled trial comparing a non-opioid prescription to the standard of care for pain control following arthroscopic knee and shoulder surgery Journal Articles
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Protocol for a multicentre, randomised, parallel-control, superiority trial comparing administration of clotting factor concentrates with a standard massive haemorrhage protocol in severely bleeding trauma patients: the FiiRST 2 trial (a 2020 EAST multicentre trial) Journal Articles
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Protocol for a randomised trial evaluating a preconception-early childhood telephone-based intervention with tailored e-health resources for women and their partners to optimise growth and development among children in Canada: a Healthy Life Trajectory Initiative (HeLTI Canada) Journal Articles
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Protocols for multi‐site trials using hyperpolarized 129Xe MRI for imaging of ventilation, alveolar‐airspace size, and gas exchange: A position paper from the 129Xe MRI clinical trials consortium Journal Articles
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Qualidade de Vida Relacionada à Saúde e Desfechos em Longo Prazo após COVID-19 Sintomática Leve: Protocolo do Estudo Pós-COVID Brasil 2 Journal Articles
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Qualidade de Vida em Longo Prazo e Desfechos após Internação por COVID-19 no Brasil: Protocolo do Estudo Pós-COVID Brasil 1 Journal Articles
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Quality of anticoagulation and use of warfarin-interacting medications in long-term care: A chart review Journal Articles
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Quality-of-Life Assessment: Patient Compliance With Questionaire Completion Journal Articles
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Quantitative muscle analysis in facioscapulohumeral muscular dystrophy using whole‐body fat‐referenced MRI: Protocol development, multicenter feasibility, and repeatability Journal Articles
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Randomization and concealment in surgical trials: a comparison between orthopaedic and non-orthopaedic randomized trials Journal Articles
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Randomized Clinical Trials — Removing Unnecessary Obstacles Journal Articles
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Rationale and design of ePPOP-ID: a multicenter randomized controlled trial using an electronic-personalized program for obesity in pregnancy to improve delivery Journal Articles
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Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) Trial: A randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery Journal Articles
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Rationale, design, implementation, and baseline characteristics of patients in the dig trial: A large, simple, long-term trial to evaluate the effect of digitalis on mortality in heart failure Journal Articles
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Re-evaluation of peri-operative cardiac risk (the MET REPAIR study) Journal Articles
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Recommended Clinical Practices for Maximizing Peritoneal Dialysis Clearances Journal Articles
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Reduction of cardiovascular events and microvascular complications in diabetes with ACE inhibitor treatment: HOPE and MICRO-HOPE Journal Articles
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Refining risk classification in childhood B acute lymphoblastic leukemia: results of DFCI ALL Consortium Protocol 05-001 Journal Articles
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Reflections 1 Year Into the 21-Center National Institutes of Health–Funded WRIST Study: A Primer on Conducting a Multicenter Clinical Trial Journal Articles
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Relation of baseline characteristics to suppression of ventricular arrhythmias during placebo and active antiarrhythmic therapy in patients after myocardial infarction. Journal Articles
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Relationship Between A1C and Fasting Plasma Glucose in Dysglycemia or Type 2 Diabetes Journal Articles
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Relationship Between Perceived and Measured Changes in Walking After Stroke Journal Articles
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Relationship of Activated Partial Thromboplastin Time to Coronary Events and Bleeding in Patients With Acute Coronary Syndromes Who Receive Heparin Journal Articles
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Remote ischemic conditioning in necrotizing enterocolitis: study protocol of a multi-center phase II feasibility randomized controlled trial Journal Articles
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Report From the Ethics Committee for Immunotherapy Journal Articles
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Research ethics board approval for an international thromboprophylaxis trial Journal Articles
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Resting state fMRI scanner instabilities revealed by longitudinal phantom scans in a multi-center study Journal Articles
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Safety and Accuracy of Sentinel Lymph Node Biopsy Alone in Clinically Node-Positive Patients Undergoing Upfront Surgery for Invasive Breast Cancer: A Systematic Review Journal Articles
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Satisfactory Analgesia with Minimal Emesis in Day Surgeries (SAME DayS): a protocol for a randomised controlled trial of morphine versus hydromorphone Journal Articles
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Second Vasovagal Pacemaker Study (VPS II): Rationale, Design, Results, and Implications for Practice and Future Clinical Trials Journal Articles
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Sex-Based Analysis of Workflow and Outcomes in Acute Ischemic Stroke Patients Treated With Alteplase Versus Tenecteplase Journal Articles
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Sharing of Lessons Learned From Multisite Research Journal Articles
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Short-course antimicrobial therapy for paediatric respiratory infections (SAFER): study protocol for a randomized controlled trial Journal Articles
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Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies Journal Articles
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Solute Clearance Approach to Adequacy of Peritoneal Dialysis Journal Articles
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Specific barriers to the conduct of randomized trials Journal Articles
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Standard Surgical Protocol to Treat Elbow Dislocations with Radial Head and Coronoid Fractures Journal Articles
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Statins and Intracerebral Hemorrhage Journal Articles
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Statistical analysis plan for a cluster-randomised trial assessing the effectiveness of implementation of a bedside evidence-based checklist for clinical management of brain-dead potential organ donors in intensive care units: DONORS (Donation Network to Optimise Organ Recovery Study) Journal Articles
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Statistical analysis plan for a cluster-randomized crossover trial comparing the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units (the ICU Visits Study) Journal Articles
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Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial Journal Articles
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Stereotactic ablative radiotherapy for the comprehensive treatment of 1–3 Oligometastatic tumors (SABR-COMET-3): study protocol for a randomized phase III trial Journal Articles
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Strategies to detect abnormal glucose metabolism in people at high risk of cardiovascular disease from the ORIGIN (Outcome Reduction with Initial Glargine Intervention) trial population Journal Articles
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Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP) randomized controlled trial Journal Articles
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Studies of Left Ventricular Dysfunction (SOLVD)—Rationale, design and methods: Two trials that evaluate the effect of enalapril in patients with reduced ejection fraction Journal Articles
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Study protocol for two complementary trials of non-steroidal or opioid analgesia use for children aged 6 to 17 years with musculoskeletal injuries (the No OUCH study) Journal Articles
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Study protocol of a phase 2, randomised, placebo-controlled, double-blind, adaptive, parallel group clinical study to evaluate the efficacy and safety of recombinant alpha-1-microglobulin in subjects at high risk for acute kidney injury following open-chest cardiac surgery (AKITA trial) Journal Articles
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Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy Journal Articles
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TB and COVID-19 co-infection: rationale and aims of a global study Journal Articles
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THE CANADIAN AMERICAN TICLOPIDINE STUDY (CATS) IN THROMBOEMBOLIC STROKE Journal Articles
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Team approach to polypharmacy evaluation and reduction: study protocol for a randomized controlled trial Journal Articles
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TeleRehabilitation with Aims to Improve Lower extremity recovery in community-dwelling individuals who have had a stroke: protocol for a multisite, parallel group, assessor-blinded, randomised attention-controlled trial Journal Articles
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Temporal Trends and Factors Associated With the Inclusion of Patient‐Reported Outcomes in Heart Failure Randomized Controlled Trials: A Systematic Review Journal Articles
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Temporal trends on the risk of arrhythmic vs. non-arrhythmic deaths in high-risk patients after myocardial infarction: a combined analysis from multicentre trials Journal Articles
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The Analysis of Multinational Cost-Effectiveness Data for Reimbursement Decisions Journal Articles
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The BEACON study: protocol for a cohort study as part of an evaluation of the effectiveness of smartphone-assisted problem-solving therapy in men who present with intentional self-harm to emergency departments in Ontario Journal Articles
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The CHORUS (Cerivastatin in Heart Outcomes in Renal Disease: Understanding Survival) protocol: A double-blind, placebo-controlled trial in patients with ESRD Conferences
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The CHORUS (Cerivastatin in Heart Outcomes in Renal Disease: Understanding Survival) protocol: a double-blind, placebo-controlled trial in patients with esrd. Journal Articles
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The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Design, organization, and baseline results. Journal Articles
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The Canadian Optimal Therapy of COPD Trial: Design, Organization and Patient Recruitment Journal Articles
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The Complexity of Conducting a Multicenter Clinical Trial: Taking It to the Next Level Stipulated by the Federal Agencies Journal Articles
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The Efficacy of Glutamine Supplementation in Severe Adult Burn Patients: A Systematic Review With Trial Sequential Meta-Analysis Journal Articles
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The Fluid Study Protocol: A Randomized Controlled Study on the Effects of Bioimpedance Analysis and Vitamin D on Left Ventricular Mass in Peritoneal Dialysis Patients Journal Articles
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The Inhaled Steroid Treatment as Regular Therapy in Early Asthma (START) Study Journal Articles
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The Internet and Clinical Trials: Background, Online Resources, Examples and Issues Journal Articles
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The Public Access Defibrillation (PAD) Trial Journal Articles
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The Salmeterol Multicenter Asthma Research Trial Journal Articles
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The Stability study: a protocol for a multicenter randomized clinical trial comparing anterior cruciate ligament reconstruction with and without Lateral Extra-articular Tenodesis in individuals who are at high risk of graft failure Journal Articles
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The Tactics of Large Randomized Trials Journal Articles
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The Transitions to Long-term In Home Ventilator Engagement Study (Transitions to LIVE): study protocol for a pragmatic randomized controlled trial Journal Articles
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The Value of Washers in Cannulated Screw Fixation of Femoral Neck Fractures Journal Articles
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The cost implications of the use of telmisartan or ramipril in patients at high risk for vascular events: the ONTARGET study Journal Articles
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The effects of nocturnal hemodialysis compared to conventional hemodialysis on change in left ventricular mass: Rationale and study design of a randomized controlled pilot study Journal Articles
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The role of the data coordinating center in the DIG trial Journal Articles
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The role of the data coordinating center in the IRB review and approval process: the DIG trial experience Journal Articles
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The role of the pharmacy coordinating center in the DIG trial Journal Articles
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The “parallel-cohort RCT”: Novel design aspects and application in the Kids-DOTT trial of pediatric venous thromboembolism Journal Articles
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Thrombosis prophylaxis in the acutely ill medical patient: insights from the prophylaxis in medical patients with enoxaparin (MEDENOX) trial Journal Articles
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Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction Journal Articles
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Tocilizumab did not reduce hypoxemic respiratory failure or death in hospitalized patients with COVID-19 Journal Articles
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Treatment Strategies in Elderly Patients with Aggressive Histology Lymphoma Journal Articles
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Trends in the utilization and wastage of coagulation factor concentrates: the application of a regional tracking programme Journal Articles
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Understanding the use and outcomes of high-flow nasal cannula among infants admitted to Canadian hospitals with bronchiolitis (CanFLO): a protocol for a multicentre, retrospective cohort study Journal Articles
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Use of the day 6 bone marrow to alter remission induction therapy in patients with acute myeloid leukaemia: a leukemia intergroup study Journal Articles
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Variations between countries in invasive cardiac procedures Journal Articles
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What counts as patient-important upper gastrointestinal bleeding in the ICU? A mixed-methods study protocol of patient and family perspectives Journal Articles
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Will this trial change my practice? TASTE - a randomised registry on thrombus aspiration in primary PCI with a 30-day endpoint Journal Articles
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Work Productivity and Healthcare Resource Utilization Outcomes for Patients on Etanercept for Moderate-to-Severe Plaque Psoriasis Journal Articles
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Xylitol for the prevention of acute otitis media episodes in children aged 2–4 years: protocol for a pragmatic randomised controlled trial Journal Articles