Multicenter Studies as Topic
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Overview
subject area of
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A Challenging Question Regarding the Use of Topical Corticosteroids for Mycosis Fungoides Academic Article
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A Practical Guide to Research: Design, Execution, and Publication Academic Article
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A community-based clinical trial of Intra-Venous zOledRonic acid once Yearly in comparison to oral bisphosphonates in postmenopausal women with osteoporosis: The IVORY trial Academic Article
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A multinational registry to study the characteristics and outcomes of heart failure patients: The global congestive heart failure (G-CHF) registry Academic Article
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A novel lung disease phenotype adjusted for mortality attrition for cystic fibrosis Genetic modifier studies Academic Article
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A phase II clinical and pharmacokinetic study of intravenous exatecan mesylate (DX-8951f) in patients with untreated metastatic gastric cancer Academic Article
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A prediction model for sudden cardiac death in patients with heart failure and preserved ejection fraction Academic Article
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A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol Academic Article
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A review of exemestane in the management of breast cancer Academic Article
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ASymptomatic atrial fibrillation and Stroke Evaluation in pacemaker patients and the atrial fibrillation Reduction atrial pacing Trial (ASSERT) Academic Article
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Accumulation of Deficits as a Key Risk Factor for Cardiovascular Morbidity and Mortality: A Pooled Analysis of 154 000 Individuals Academic Article
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Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials Academic Article
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Acupuncture treatment for knee osteoarthritis with sensitive points: protocol for a multicentre randomised controlled trial Academic Article
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Acute myelogenous leukemia in adolescents and young adults Academic Article
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Adjudicating Outcomes: Fundamentals Academic Article
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Adjudicating ventilator-associated pneumonia in a randomized trial of critically ill patients Academic Article
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Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials Academic Article
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Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis Academic Article
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Adjuvant/neoadjuvant trastuzumab therapy in women with HER-2/neu-overexpressing breast cancer: A systematic review Academic Article
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Age of the female partner is a prognostic factor in prolonged unexplained infertility: a multicenter study *† Academic Article
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Agreement in reporting between trial publications and current clinical trial registry in high impact journals: A methodological review Academic Article
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Analysis of Regional Timelines To Set Up a Global Phase III Clinical Trial in Breast Cancer: The Adjuvant Lapatinib and/or Trastuzumab Treatment Optimization Experience Academic Article
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Antibiotic Review Kit for Hospitals (ARK-Hospital): study protocol for a stepped-wedge cluster-randomised controlled trial Academic Article
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Anticoagulant therapy after acute myocardial infarction Academic Article
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Antivirals for influenza-Like Illness? A randomised Controlled trial of Clinical and Cost effectiveness in primary CarE (ALIC4E): the ALIC4E protocol Academic Article
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Are large clinical trials in orthopaedic trauma justified? Academic Article
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Aspirin Versus Low-Molecular-Weight Heparin for Ischemic Stroke in Children: An Unanswered Question Academic Article
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Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study Academic Article
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Association of cyclooxygenase-2 genetic variant with cardiovascular disease Academic Article
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Association of mitral annular calcification and aortic valve morphology: a substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study Academic Article
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At-risk registers integrated into primary care to stop asthma crises in the UK (ARRISA-UK): study protocol for a pragmatic, cluster randomised trial with nested health economic and process evaluations Academic Article
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Becoming and staying physically active in adolescents with cerebral palsy: protocol of a qualitative study of facilitators and barriers to physical activity Academic Article
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Bone Turnover Markers as Predictors of Skeletal Complications in Prostate Cancer, Lung Cancer, and Other Solid Tumors Academic Article
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Burden of Proof for Tolvaptan in ADPKD Academic Article
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Burden of respiratory syncytial virus hospitalisation among infants born at 32–35 weeks' gestational age in the Northern Hemisphere: pooled analysis of seven studies Academic Article
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CANadian Network and Centre for Trials INternationally (CANNeCTIN): A national network for Canadian-led trials in cardiovascular diseases and diabetes mellitus Academic Article
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Can orthopedic trials change practice? Academic Article
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Candidemia in patients with diabetes mellitus: epidemiology and predictors of mortality Academic Article
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Care and outcomes of Canadian children hospitalised with periorbital and orbital cellulitis: protocol for a multicentre, retrospective cohort study Academic Article
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Carotid plaque formation and its evaluation with angiography, ultrasound, and MR angiography Academic Article
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Cefoperazone compared with ampicillin plus tobramycin for severe biliary tract infections. Academic Article
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Central statistical monitoring: Detecting fraud in clinical trials Academic Article
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Challenges in the conduct of large simple trials of important generic questions in resource-poor settings: The CREATE and ECLA trial program evaluating GIK (glucose, insulin and potassium) and low-molecular-weight heparin in acute myocardial infarction Academic Article
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Challenges to complete and useful data sharing Academic Article
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Choices of Methodology in Pharmacoeconomic Studies Academic Article
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Choisir un questionnaire de qualité de vie Academic Article
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Classification and appraisal of the level of clinical evidence of publications from the Canadian Association of Pediatric Surgeons for the past 10 years Academic Article
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Clinical trial update: National Cancer Institute of Canada Academic Article
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Cognitive impairment and risk of cardiovascular events and mortality Academic Article
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Collaborative multicenter trials in Latin America: challenges and opportunities in orthopedic and trauma surgery Academic Article
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Combined Analysis of Asthma Safety Trials of Long-Acting β2-Agonists Academic Article
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Comment on ‘A multicentre randomized controlled trial of expectant management versus IVF in women with Fallopian tube patency’ Academic Article
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Comparative Therapeutic Studies with Tilavist Academic Article
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Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study Academic Article
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Comparison of 12 Risk Stratification Schemes to Predict Stroke in Patients With Nonvalvular Atrial Fibrillation Academic Article
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Comparisons of cause of death verification methods and costs in the lipid research clinics program mortality follow-up study Academic Article
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Complex care for kids Ontario: protocol for a mixed-methods randomised controlled trial of a population-level care coordination initiative for children with medical complexity Academic Article
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Conducting economic evaluations alongside multinational clinical trials: Toward a research consensus Academic Article
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Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials Academic Article
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Construction of a FRAX® model for the assessment of fracture probability in Canada and implications for treatment Academic Article
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Contrasting evidence to reimbursement reality for off-label use (OLU) of drug treatments in cancer care: rationale and design of the CEIT-OLU project Academic Article
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Coordination of international multicenter studies: governance and administrative structure Academic Article
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Coronary stenting in diabetic patients: Results from the ROSETTA registry Academic Article
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Cost Implications of the Use of Ramipril in High-Risk Patients Based on the Heart Outcomes Prevention Evaluation (HOPE) Study Academic Article
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Cost‐effectiveness analysis of a multinational RCT with a binary measure of effectiveness and an interacting covariate Academic Article
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Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis Academic Article
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Cytoreductive nephrectomy in metastatic renal cell carcinoma: the evolving role of surgery in the era of molecular targeted therapy Academic Article
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Design and Analytic Considerations in Determining the Cost-Effectiveness of Early Intervention in Asthma from a Multinational Clinical Trial Academic Article
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Design and baseline characteristics of participants in the
R
esearching cardiovascular
E
vents with a
W
eekly
IN
cretin in
D
iabetes (
REWIND
) trial on the cardiovascular effects of dulaglutide Academic Article
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Design and rationale of the Clinical Outcomes Utilizing Revascularization and Aggressive DruG Evaluation (COURAGE) trial Academic Article
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Design of the INPULSIS™ trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis Academic Article
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Development of a clinical prediction model for the postthrombotic syndrome in a prospective cohort of patients with proximal deep vein thrombosis Academic Article
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Diabetes mellitus, a predictor of morbidity and mortality in the studies of left ventricular dysfunction (SOLVD) trials and registry Academic Article
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Diarrhoea: interventions, consequences and epidemiology in the intensive care unit (DICE-ICU): a protocol for a prospective multicentre cohort study Academic Article
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Donepezil and rivastigmine in the treatment of Alzheimer's disease: a best-evidence synthesis of the published data on their efficacy and cost-effectiveness Academic Article
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Economic Evaluation of Rivastigmine in Patients with Parkinson??s Disease Dementia Academic Article
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Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol Academic Article
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Effect of Angiotensin-Converting Enzyme Inhibitors in Left Ventricular Dysfunction Academic Article
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Effect of acute angiotensin converting enzyme inhibition on left ventricular filling in patients with congestive heart failure. Relation to right ventricular volumes. Academic Article
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Effect of age on mortality, hospitalizations and response to digoxin in patients with heart failure: the DIG study Academic Article
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Effect of visceral metastases on the efficacy and safety of everolimus in postmenopausal women with advanced breast cancer: Subgroup analysis from the BOLERO-2 study Academic Article
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Effectiveness and safety of Chinese herbal medicine xuanbi antong granules for the treatment of borderline coronary lesions: study protocol for a randomised, double-blinded, placebo-controlled, multicentre clinical trial Academic Article
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Effectiveness of Dorzolamide–Timolol (COSOPT) in Patients Who Were Treatment Naive for Open-Angle Glaucoma or Ocular Hypertension: The COSOPT First-Line Study Academic Article
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Effects of Dronedarone Started Rapidly After Amiodarone Discontinuation Academic Article
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Effects of exercise interventions on cardiovascular health in individuals with chronic, motor complete spinal cord injury: protocol for a randomised controlled trial [Cardiovascular Health/Outcomes: Improvements Created by Exercise and education in SCI (CHOICES) Study] Academic Article
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Efficacy and tolerability of a “suprabioavailable” formulation of fenofibrate in patients with dyslipidemia: a pooled analysis of two open-label trials Academic Article
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Emergence of the Primary Pediatric Stroke Center Academic Article
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Endovascular therapy for advanced post-thrombotic syndrome: Proceedings from a multidisciplinary consensus panel Academic Article
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Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT Academic Article
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Evaluating the effectiveness of rosuvastatin in preventing the progression of diastolic dysfunction in aortic stenosis: A substudy of the aortic stenosis progression observation measuring effects of rosuvastatin (ASTRONOMER) study Academic Article
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Evaluation of Buspirone as an Antianxiety Agent: Buspirone and Diazepam versus Placebo* Academic Article
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Evaluation of outcome and cost-effectiveness using an FDG PET-guided approach to management of patients with coronary disease and severe left ventricular dysfunction (PARR-2): rationale, design, and methods Academic Article
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Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis Academic Article
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Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol Academic Article
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Factors affecting blood pressure responses to diet: The vanguard study Academic Article
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Favourable outcome in 135 children with juvenile systemic sclerosis: results of a multi‐national survey Academic Article
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Femoroacetabular Impingement Randomised controlled Trial (FIRST) - a multi-centre randomized controlled trial comparing arthroscopic lavage and arthroscopic osteochondroplasty on patient important outcomes and quality of life in the treatment of young adult (18–50 years) femoroacetabular impingement: a statistical analysis plan Academic Article
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Fondaparinux vs Enoxaparin for the Prevention of Venous Thromboembolism in Major Orthopedic SurgeryA Meta-analysis of 4 Randomized Double-blind Studies Academic Article
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Fracture Risk Assessment in Chronic Kidney Disease, Prospective Testing Under Real World Environments (FRACTURE): a prospective study Academic Article
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Fracture prediction and calibration of a Canadian FRAX® tool: a population-based report from CaMos Academic Article
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Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial Academic Article
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Gemifloxacin versus Amoxicillin/Clavulanate in the Treatment of Acute Exacerbations of Chronic Bronchitis Academic Article
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Generalizability of results from the recent FDA-guided cardiovascular outcomes trials to a representative population with Type 2 Diabetes attending primary care clinics Academic Article
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Globally optimal trial design for local decision making Academic Article
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Haemorrhagic and thromboembolic complications versus intensity of treatment of venous thromboembolism with oral anticoagulants. Academic Article
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Health-Related Quality of Life at Age 10 Years in Very Low-Birth-WeightChildren With and Without Threshold Retinopathy of Prematurity Academic Article
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Hemostatic efficacy of pathogen-inactivated vs untreated platelets: a randomized controlled trial Academic Article
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High Dose Therapy with Stem Cell Support for Breast Cancer: The Jury Is Still Out Academic Article
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High-Sensitivity Cardiac Troponin—Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women (CODE-MI): Rationale and design for a multicenter, stepped-wedge, cluster-randomized trial Academic Article
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Hospital Selection for Unit Cost Estimates in Multicentre Economic Evaluations Academic Article
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How Did We Get Here?: A Historical Review and Critical Analysis of Anticoagulation Therapy Following Mechanical Valve Replacement Academic Article
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Human Papillomavirus Triage of Atypical Squamous Cells of Undetermined Significance: Cost-Effective, But At What Cost? Academic Article
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Immunosuppressive activity in human in vitro fertilization (IVF) culture supernatants and prediction of the outcome of embryo transfer: A multicenter trial Academic Article
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Impact of Diabetes on Long-Term Prognosis in Patients With Unstable Angina and Non–Q-Wave Myocardial Infarction Academic Article
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Implementation of Timeline Reforms Speeds Initiation of National Cancer Institute-Sponsored Trials Academic Article
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Improving management of patients with acute cough by C-reactive protein point of care testing and communication training (IMPAC3T): study protocol of a cluster randomised controlled trial Academic Article
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Incidence of venous thromboembolism in patients undergoing thoracotomy for lung cancer Academic Article
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Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia Academic Article
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Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients Academic Article
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Insights into the role of thrombin in the pathogenesis of recurrent ischaemia after acute coronary syndrome Academic Article
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Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project Academic Article
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International longitudinal registry of patients with atrial fibrillation at risk of stroke: Global Anticoagulant Registry in the FIELD (GARFIELD) Academic Article
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International point prevalence study of Intensive Care Unit transfusion practices—Pilot study in the Netherlands Academic Article
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Interpreting Geographic Variations in Results of Randomized, Controlled Trials Academic Article
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Iron overload in myelodysplastic syndromes: Evidence based guidelines from the Canadian consortium on MDS Academic Article
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Is a Restrictive Transfusion Strategy Safe for Resuscitated and Critically Ill Trauma Patients? Academic Article
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Launch of the Canadian Neurosurgery Research Collaborative Academic Article
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Lessons learned from enrollment in the BEST study—A multicenter, randomized trial of group psychosocial support in metastatic breast cancer Academic Article
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Lessons learned from the DIG trial Academic Article
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Limiting loss to follow-up in a multicenter randomized trial in orthopedic surgery Academic Article
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Long-term outcomes of total elbow arthroplasty for distal humeral fracture: results from a prior randomized clinical trial Academic Article
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Longitudinal Youth in Transition Study (LYiTS): protocol for a multicentre prospective cohort study of youth transitioning out of child and adolescent mental health services at age 18 Academic Article
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Low-Molecular-Weight Heparin or Oral Anticoagulation for Secondary Prevention of Deep Vein Thrombosis in Cancer Patients Academic Article
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Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis Academic Article
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Markers of Bone Metabolism and Survival in Men with Hormone-Refractory Metastatic Prostate Cancer Academic Article
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Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes Academic Article
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Meta-analysis of antiarrhythmic drug trials Academic Article
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Moving forward through consensus: protocol for a modified Delphi approach to determine the top research priorities in the field of orthopaedic oncology Academic Article
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Multicenter Collaboration in Observational Research: Improving Generalizability and Efficiency Academic Article
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Multicenter Study of General Anesthesia. I. Design and Patient Demography Academic Article
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Multicenter Study of General Anesthesia. II. Results Academic Article
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Multicenter clinical research in adult critical care Academic Article
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Multistate Analysis of Skeletal Events in Patients with Bone Metastases Conference Paper
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National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: VI. Design of Clinical Trials Working Group Report Academic Article
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Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials Academic Article
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New Strategies for the Optimal Use of Platelet Transfusions Academic Article
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Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness Academic Article
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Once-Daily Therapy with Ceftriaxone Compared with Daily Multiple-Dose Therapy with Cefotaxime for Serious Bacterial Infections: A Randomized, Double-Blind Study Academic Article
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Ontario Cancer Research Ethics Board: Lessons Learned From Developing a Multicenter Regional Institutional Review Board Academic Article
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Opportunities for enhancing the care of older patients with ST-elevation myocardial infarction presenting for primary percutaneous coronary intervention: Rationale and design of the SAFE-STEMI for Seniors trial Academic Article
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Optimisation of Perioperative Cardiovascular Management to Improve Surgical Outcome II (OPTIMISE II) trial: study protocol for a multicentre international trial of cardiac output-guided fluid therapy with low-dose inotrope infusion compared with usual care in patients undergoing major elective gastrointestinal surgery Academic Article
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Outcome assessment for clinical trials: How many adjudicators do we need? Academic Article
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Overview of the DIG trial Academic Article
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POP-Brazil study protocol: a nationwide cross-sectional evaluation of the prevalence and genotype distribution of human papillomavirus (HPV) in Brazil Academic Article
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PROphylaxis for ThromboEmbolism in Critical Care Trial protocol and analysis plan Academic Article
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Participating in Multicenter Randomized Controlled Trials: What’s the Relative Value? Academic Article
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Patient and caregiver involvement in a multicentre clustered hemodialysis trial Academic Article
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Patient engagement in research related to accelerated surgical care and treatment for hip fracture Academic Article
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Patterns of Medication Use in Patients With Heart Failure Academic Article
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Peri-Operative Eltrombopag or Immune Globulin for Patients with Immune Thrombocytopaenia (The Bridging ITP Trial): Methods and Rationale Academic Article
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Personalized pharmacotherapy in diabetes care using clinical pharmacology data of basal insulin analogues Academic Article
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Perturbation training to promote safe independent mobility post-stroke: study protocol for a randomized controlled trial Academic Article
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Pharmacological Actions of Sulodexide Academic Article
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Physical activity in patients with stable coronary heart disease: an international perspective Academic Article
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Plasma Matrix Metalloproteinase-9 Level Is Correlated With Left Ventricular Volumes and Ejection Fraction in Patients With Heart Failure Academic Article
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Plasma exchange in Canada. The Canadian Apheresis Study Group. Academic Article
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Platelet function testing: does a randomized controlled trial settle the debate? Academic Article
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Pooling Birth Cohorts in Allergy and Asthma: European Union-Funded Initiatives A MeDALL, CHICOS, ENRIECO, and GA2LEN Joint Paper Academic Article
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Positive Effect of Etidronate Therapy Is Maintained After Drug Is Terminated in Patients Using Corticosteroids Academic Article
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Postmenopausal breast cancer: is the short-term pain worth the long-term gain? Academic Article
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Potential demographic and baselines variables for risk stratification of high-risk post-myocardial infarction patients in the era of implantable cardioverter-defibrillator — A prognostic indicator Academic Article
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Practical Understanding of Mean Percent Psoriasis Area and Severity Index Reduction for Biologics Academic Article
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Predicting Malignancy Risk of Screen-Detected Lung Nodules–Mean Diameter or Volume Academic Article
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Predictors of clinical outcome in patients with heparin-induced thrombocytopenia treated with direct thrombin inhibition Academic Article
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Predictors of treatment response in patients with non-erosive reflux disease Academic Article
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Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial Academic Article
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Prevention of venous thromboembolism in medical patients with enoxaparin Academic Article
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Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Con: the hazards of stopping for futility. Academic Article
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Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility. Pro: Futility stopping can speed up the development of effective treatments. Academic Article
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Pro: “Anti-platelet therapy is an alternative to oral anticoagulation for atrial fibrillation” Academic Article
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Prognostic impact of demographic factors and clinical features on the mode of death in high-risk patients after myocardial infarction - A combined analysis from multicenter trials Academic Article
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Progression to chronic atrial fibrillation after pacing: the Canadian Trial of Physiologic Pacing Academic Article
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Project management lessons learned from the multicentre CYCLE pilot randomized controlled trial Academic Article
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Propensity score matched comparison of subcutaneous and transvenous implantable cardioverter-defibrillator therapy in the SIMPLE and EFFORTLESS studies Academic Article
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Prospective Surveillance for Primary Bloodstream Infections Occurring in Canadian Hemodialysis Units Academic Article
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Protecting Human Research Participants: Reading vs Understanding the Consent Form Academic Article
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Protocol for a multicenter prospective cohort study evaluating sport activity and development of femoroacetabular impingement in the adolescent hip Academic Article
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Quality of anticoagulation and use of warfarin-interacting medications in long-term care: A chart review Academic Article
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Randomization and concealment in surgical trials: a comparison between orthopaedic and non-orthopaedic randomized trials Academic Article
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Randomized Clinical Trials — Removing Unnecessary Obstacles Academic Article
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Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) Trial: A randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery Academic Article
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Rationale, design, implementation, and baseline characteristics of patients in the dig trial: A large, simple, long-term trial to evaluate the effect of digitalis on mortality in heart failure Academic Article
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Re-evaluation of peri-operative cardiac risk (the MET REPAIR study) Academic Article
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Recommended Clinical Practices for Maximizing Peritoneal Dialysis Clearances Academic Article
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Reduction of cardiovascular events and microvascular complications in diabetes with ACE inhibitor treatment: HOPE and MICRO-HOPE Academic Article
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Refining risk classification in childhood B acute lymphoblastic leukemia: results of DFCI ALL Consortium Protocol 05-001 Academic Article
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Reflections 1 Year Into the 21-Center National Institutes of Health–Funded WRIST Study: A Primer on Conducting a Multicenter Clinical Trial Academic Article
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Relation of baseline characteristics to suppression of ventricular arrhythmias during placebo and active antiarrhythmic therapy in patients after myocardial infarction. Academic Article
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Relationship Between A1C and Fasting Plasma Glucose in Dysglycemia or Type 2 Diabetes: An analysis of baseline data from the ORIGIN trial Academic Article
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Relationship Between Perceived and Measured Changes in Walking After Stroke Academic Article
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Relationship of Activated Partial Thromboplastin Time to Coronary Events and Bleeding in Patients With Acute Coronary Syndromes Who Receive Heparin Academic Article
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Renal hypothermia during partial nephrectomy for patients with renal tumours: a randomised controlled clinical trial protocol Academic Article
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Report From the Ethics Committee for Immunotherapy Academic Article
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Research ethics board approval for an international thromboprophylaxis trial Academic Article
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Risk Scores for Occult Cancer in Patients with Venous Thromboembolism: A Post Hoc Analysis of the Hokusai-VTE Study Academic Article
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Satisfactory Analgesia with Minimal Emesis in Day Surgeries (SAME DayS): a protocol for a randomised controlled trial of morphine versus hydromorphone Academic Article
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Second Vasovagal Pacemaker Study (VPS II): Rationale, Design, Results, and Implications for Practice and Future Clinical Trials Academic Article
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Sharing of Lessons Learned From Multisite Research Academic Article
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Short-course antimicrobial therapy for paediatric respiratory infections (SAFER): study protocol for a randomized controlled trial Academic Article
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Single pivotal trials with few corroborating characteristics were used for FDA approval of cancer therapies Academic Article
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Solute Clearance Approach to Adequacy of Peritoneal Dialysis Academic Article
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Specific barriers to the conduct of randomized trials Academic Article
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Standard Surgical Protocol to Treat Elbow Dislocations with Radial Head and Coronoid Fractures Academic Article
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Statins and Intracerebral Hemorrhage Academic Article
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Statistical analysis plan for a cluster-randomised trial assessing the effectiveness of implementation of a bedside evidence-based checklist for clinical management of brain-dead potential organ donors in intensive care units: DONORS (Donation Network to Optimise Organ Recovery Study) Academic Article
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Statistical analysis plan for a cluster-randomized crossover trial comparing the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units (the ICU Visits Study) Academic Article
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Statistical analysis plan for the Pneumatic CompREssion for PreVENting Venous Thromboembolism (PREVENT) trial: a study protocol for a randomized controlled trial Academic Article
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Strategies to detect abnormal glucose metabolism in people at high risk of cardiovascular disease from the ORIGIN (Outcome Reduction with Initial Glargine Intervention) trial population Academic Article
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Structured diet and exercise guidance in pregnancy to improve health in women and their offspring: study protocol for the Be Healthy in Pregnancy (BHIP) randomized controlled trial Academic Article
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Study protocol for two complementary trials of non-steroidal or opioid analgesia use for children aged 6 to 17 years with musculoskeletal injuries (the No OUCH study) Academic Article
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Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31,000 recurrences and 24,000 deaths among 75,000 women. Early Breast Cancer Trialists' Collaborative Group. Academic Article
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THE CANADIAN AMERICAN TICLOPIDINE STUDY (CATS) IN THROMBOEMBOLIC STROKE Academic Article
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Temporal evolution in the management of acute ST elevation myocardial infarction: the seven-year GUSTO experience from canada and the united states. The North American GUSTO-I and GUSTO-III investigators. Academic Article
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Temporal trends on the risk of arrhythmic vs. non-arrhythmic deaths in high-risk patients after myocardial infarction: a combined analysis from multicentre trials Academic Article
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The Analysis of Multinational Cost-Effectiveness Data for Reimbursement Decisions Academic Article
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The CHORUS (Cerivastatin in Heart Outcomes in Renal Disease: Understanding Survival) protocol: a double-blind, placebo-controlled trial in patients with esrd. Academic Article
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The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Design, organization, and baseline results. Academic Article
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The Complexity of Conducting a Multicenter Clinical Trial Academic Article
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The Fluid Study Protocol: A Randomized Controlled Study on the Effects of Bioimpedance Analysis and Vitamin D on Left Ventricular Mass in Peritoneal Dialysis Patients Academic Article
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The Inhaled Steroid Treatment as Regular Therapy in Early Asthma (START) Study Academic Article
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The Public Access Defibrillation (PAD) Trial Academic Article
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The Salmeterol Multicenter Asthma Research Trial Academic Article
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The Stability study: a protocol for a multicenter randomized clinical trial comparing anterior cruciate ligament reconstruction with and without Lateral Extra-articular Tenodesis in individuals who are at high risk of graft failure Academic Article
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The Tactics of Large Randomized Trials Academic Article
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The Value of Washers in Cannulated Screw Fixation of Femoral Neck Fractures Academic Article
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The cost implications of the use of telmisartan or ramipril in patients at high risk for vascular events: the ONTARGET study Academic Article
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The effects of nocturnal hemodialysis compared to conventional hemodialysis on change in left ventricular mass: Rationale and study design of a randomized controlled pilot study Academic Article
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The role of the data coordinating center in the DIG trial Academic Article
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The role of the data coordinating center in the IRB review and approval process: the DIG trial experience Academic Article
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The role of the pharmacy coordinating center in the DIG trial Academic Article
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The “parallel-cohort RCT”: Novel design aspects and application in the Kids-DOTT trial of pediatric venous thromboembolism Academic Article
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Thrombosis prophylaxis in the acutely ill medical patient: insights from the prophylaxis in medical patients with enoxaparin (MEDENOX) trial Academic Article
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Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction Academic Article
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Tocilizumab did not reduce hypoxemic respiratory failure or death in hospitalized patients with COVID-19 Academic Article
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Treatment strategies in elderly patients with aggressive histology lymphoma. Academic Article
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Trends in the utilization and wastage of coagulation factor concentrates: the application of a regional tracking programme Academic Article
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Use of the day 6 bone marrow to alter remission induction therapy in patients with acute myeloid leukaemia: a leukemia intergroup study Academic Article
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Variations between countries in invasive cardiac procedures Academic Article
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Will this trial change my practice? TASTE - a randomised registry on thrombus aspiration in primary PCI with a 30-day endpoint Academic Article
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Work Productivity and Healthcare Resource Utilization Outcomes for Patients on Etanercept for Moderate-to-Severe Plaque Psoriasis Academic Article
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Xylitol for the prevention of acute otitis media episodes in children aged 2–4 years: protocol for a pragmatic randomised controlled trial Academic Article
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[The use of state of the art statistical methodology in biomedical research: the example of methodology for interim analyses in clinical trials]. Academic Article