Journal article
Enrolment patterns in a randomized controlled trial of probiotics in critically ill patients: a retrospective analysis of the PROSPECT trial
Abstract
BackgroundUnderstanding site-related factors that influence enrolment within multicenter randomized controlled trials (RCT) may help reduce trial delays and cost over-runs and prevent early trial discontinuation. In this analysis of PROSPECT (Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial), we describe patient enrolment patterns and examine factors influencing site-based monthly enrolment.DesignRetrospective …
Authors
Takaoka A; Johnstone J; Lauzier F; Heels-Ansdell D; Davis M; Zytaruk N; Duan E; Dionne J; Saunders L; Arabi YM
Journal
Trials, Vol. 25, No. 1,
Publisher
Springer Nature
DOI
10.1186/s13063-024-08701-w
ISSN
1468-6708