Journal article
Association of cyclooxygenase-2 genetic variant with cardiovascular disease
Abstract
AIM: A genetic variant (rs20417) of the PTGS2 gene, encoding for COX-2, has been associated with decreased COX-2 activity and a decreased risk of cardiovascular disease (CVD). However, this genetic association and the role of COX-2 in CVD remain controversial.
METHODS AND RESULTS: The association of rs20417 with CVD was prospectively explored in 49 232 subjects (ACTIVE-A, CURE, epiDREAM/DREAM, ONTARGET, RE-LY, and WGHS) and the effect of …
Authors
Ross S; Eikelboom J; Anand SS; Eriksson N; Gerstein HC; Mehta S; Connolly SJ; Rose L; Ridker PM; Wallentin L
Journal
European Heart Journal, Vol. 35, No. 33, pp. 2242–2248
Publisher
Oxford University Press (OUP)
Publication Date
September 1, 2014
DOI
10.1093/eurheartj/ehu168
ISSN
0195-668X