Journal article
Comparing methods to estimate treatment effects on a continuous outcome in multicentre randomized controlled trials: A simulation study
Abstract
BackgroundMulticentre randomized controlled trials (RCTs) routinely use randomization and analysis stratified by centre to control for differences between centres and to improve precision. No consensus has been reached on how to best analyze correlated continuous outcomes in such settings. Our objective was to investigate the properties of commonly used statistical models at various levels of clustering in the context of multicentre …
Authors
Chu R; Thabane L; Ma J; Holbrook A; Pullenayegum E; Devereaux PJ
Journal
BMC Medical Research Methodology, Vol. 11, No. 1,
Publisher
Springer Nature
Publication Date
12 2011
DOI
10.1186/1471-2288-11-21
ISSN
1471-2288