Substrate Specificity Concept

subject area of

• Chlamydophila pneumoniae PknD Exhibits Dual Amino Acid Specificity and Phosphorylates Cpn0712, a Putative Type III Secretion YscD Homolog  Journal Articles
• In Vitro Survival of Nonsmall Cell Lung Cancer Cells Following Combined Treatment with Ionizing Radiation and Photofrin‐mediated Photodynamic Therapy  Journal Articles
• Staphylococcus aureus Fibronectin-Binding Protein Serves as a Substrate for Coagulation Factor XIIIa:  Evidence for Factor XIIIa-Catalyzed Covalent Cross-Linking to Fibronectin and Fibrin  Journal Articles
• A Deoxyribozyme with a Novel Guanine Quartet-Helix Pseudoknot Structure  Journal Articles
• A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor  Journal Articles
• A New Strategy for the Preparation of Peptide-Targeted Technetium and Rhenium Radiopharmaceuticals. The Automated Solid-Phase Synthesis, Characterization, Labeling, and Screening of a Peptide-Ligand Library Targeted at the Formyl Peptide Receptor  Journal Articles
• A Thiolate Anion Buried within the Hydrocarbon Ruler Perturbs PagP Lipid Acyl Chain Selection  Journal Articles
• A Versatile Endoribonuclease Mimic Made of DNA: Characteristics and Applications of the 8–17 RNA‐Cleaving DNAzyme  Journal Articles
• A diverse intrinsic antibiotic resistome from a cave bacterium  Journal Articles
• A glycosyl hydrolase activity of mammalian reovirus σ1 protein can contribute to viral infection through a mucus layer 1 1Edited by M. Yaniv  Journal Articles
• A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin  Journal Articles
• A shotgun lipidomics study of a putative lysophosphatidic acid acyl transferase (PlsC) in Sinorhizobium meliloti  Journal Articles
• Acetyltransfer Precedes Uridylyltransfer in the Formation of UDP-N-acetylglucosamine in Separable Active Sites of the Bifunctional GlmU Protein of Escherichia coli  Journal Articles
• Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP  Journal Articles
• Adenosine kinase and ribokinase – the RK family of proteins  Journal Articles
• Aerial development in Streptomyces coelicolor requires sortase activity  Journal Articles
• Aminoglycoside phosphotransferases: proteins, structure, and mechanism  Journal Articles
• An ESI‐MS/MS Method for Screening of Small‐Molecule Mixtures against Glycogen Synthase Kinase‐3β (GSK‐3β)  Journal Articles
• An Efficient RNA-Cleaving DNA Enzyme that Synchronizes Catalysis with Fluorescence Signaling  Journal Articles
• An assay for ribonucleotide reductase based on ion-exchange chromatography of the reaction product  Journal Articles
• Appearance of a second form of hepatic glycerol-3-phosphate dehydrogenase during neonatal development in the mouse  Journal Articles
• Benefit of Selective Factor Inhibition  Journal Articles
• Biosynthetic Pathway for Mannopeptimycins, Lipoglycopeptide Antibiotics Active against Drug-Resistant Gram-Positive Pathogens  Journal Articles
• Bone recognition mechanism of porcine osteocalcin from crystal structure  Journal Articles
• Broad Spectrum Aminoglycoside Phosphotransferase Type III from Enterococcus: Overexpression, Purification, and Substrate Specificity  Journal Articles
• CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi–Bi reaction mechanism with micromolar Km values  Journal Articles
• Ca2+ and Zn2+ binding properties of peptide substrates of vertebrate collagenase, MMP-1  Journal Articles
• Catalytic Residues and an Electrostatic Sandwich That Promote Enolpyruvyl Shikimate 3-Phosphate Synthase (AroA) Catalysis  Journal Articles
• Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake  Journal Articles
• Characterization of DalS, an ATP-binding Cassette Transporter for d-Alanine, and Its Role in Pathogenesis in Salmonella enterica  Journal Articles
• Characterization of an RNA-Cleaving Deoxyribozyme with Optimal Activity at pH 5  Journal Articles
• Characterization of neurotensin binding to rat gastric smooth muscle receptor sites  Journal Articles
• Cleavage-dependent Ligation by the FLP Recombinase  Journal Articles
• Conformation of a synthetic hexapeptide substrate of collagen lysyl hydroxylase  Journal Articles
• Conformational Studies on Calcium Binding BytBoc-Leu-Pro-Tyr-Ala-NHCH₃, a Tyrosine Kinase Substrate, in a Nonpolar Solvent  Journal Articles
• Conformational requirement for lysine hydroxylation in collagen. Structural studies on synthetic peptide substrates of lysyl hydroxylase.  Journal Articles
• Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise  Journal Articles
• Cross-chimeric analysis of selectivity of secretin and VPAC(1) receptor activation.  Journal Articles
• Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal  Journal Articles
• Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: Examination of structural basis for kinetic mechanism  Journal Articles
• Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold  Journal Articles
• Cyclopropane fatty acyl synthase in Sinorhizobium meliloti  Journal Articles
• Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function  Journal Articles
• DdlN from Vancomycin-Producing Amycolatopsis orientalis C329.2 Is a VanA Homologue with d -Alanyl- d -Lactate Ligase Activity  Journal Articles
• Determination of soluble CAMP-dependent protein kinase activity in guinea-pig tracheal smooth muscle  Journal Articles
• Determination of the Topology of the Hydrophobic Segment of Mammalian Diacylglycerol Kinase Epsilon in a Cell Membrane and Its Relationship to Predictions from Modeling  Journal Articles
• Development of Opiate ([3H]Naloxone)-Binding Sites in Female Rabbit Brain: Correlation with Prepubertal Gonadotropin Secretion1  Journal Articles
• Differences in prethrombin-1 activation with human or bovine factor Va can be attributed to the heavy chain  Journal Articles
• Dinucleotide Junction Cleavage Versatility of 8-17 Deoxyribozyme  Journal Articles
• Distinct surfaces on Cdc5/PLK Polo-box domain orchestrate combinatorial substrate recognition during cell division  Journal Articles
• Dynamically Driven Ligand Selectivity in Cyclic Nucleotide Binding Domains  Journal Articles
• Effect of acute plasma volume expansion on substrate turnover during prolonged low-intensity exercise  Journal Articles
• Effect of acute plasma volume expansion on substrate turnover during prolonged low-intensity exercise  Journal Articles
• Electronic Anabolic Steroid Recognition with Carbon Nanotube Field-Effect Transistors  Journal Articles
• Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.  Journal Articles
• Exploring Intermolecular Interactions of a Substrate Binding Protein Using a Riboswitch-Based Sensor  Journal Articles
• Expression and Secretion Hierarchy in the Nonflagellar Type III Secretion System  Journal Articles
• Expression of Human Prohormone Convertase PC2 in a Baculovirus-Insect Cell System  Journal Articles
• Expression of recombinant human casein kinase II and recombinant heat shock protein 90 in Escherichia coli and characterization of their interactions.  Journal Articles
• Fluorous ligand capture (FLC): a chemoselective solution-phase strategy for isolating 99mTc-labelled compounds in high effective specific activity  Journal Articles
• Functional differences in the cytochrome P450 1 family enzymes from Zebrafish (Danio rerio) using heterologously expressed proteins  Journal Articles
• Gaucher disease. III. Substrate specificity of glucocerebrosidase and the use of nonlabeled natural substrates for the investigation of patients.  Journal Articles
• Gauging a Hydrocarbon Ruler by an Intrinsic Exciton Probe  Journal Articles
• Genetic and Molecular Analysis of GogB, a Phage-encoded Type III-secreted Substrate in Salmonella enterica Serovar Typhimurium with Autonomous Expression from its Associated Phage  Journal Articles
• Glycosaminoglycans Bind Factor Xa in a Ca²⁺-Dependent Fashion and Modulate Its Catalytic Activity  Journal Articles
• High throughput protease profiling comprehensively defines active site specificity for thrombin and ADAMTS13  Journal Articles
• Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis  Journal Articles
• Homology Requirements for Ligation and Strand Exchange by the FLP Recombinase  Journal Articles
• Human kallikrein 4: enzymatic activity, inhibition, and degradation of extracellular matrix proteins  Conferences
• Identification and characterization of the proteolytic flagellin from the common freshwater bacterium Hylemonella gracilis  Journal Articles
• Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β‐Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry  Journal Articles
• Identification of a conserved 8 aa insert in the PIP5K protein in the Saccharomycetaceae family of fungi and the molecular dynamics simulations and structural analysis to investigate its potential functional role  Journal Articles
• Identification of likely orthologs of tobacco salicylic acid‐binding protein 2 and their role in systemic acquired resistance in Arabidopsis thaliana  Journal Articles
• Identification of the Ice-Binding Surface on a Type III Antifreeze Protein with a “Flatness Function” Algorithm  Journal Articles
• Identification of the Mechanism Responsible for the Increased Fibrin Specificity of TNK-Tissue Plasminogen Activator Relative to Tissue Plasminogen Activator  Journal Articles
• In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development  Journal Articles
• Induction and substrate specificity of the lanosterol 14 alpha-demethylase from Saccharomyces cerevisiae Y222  Journal Articles
• Inhibition inversion in the AACC selected method for serum cholinesterase.  Journal Articles
• Interaction of Peptide Substrates of Fibroblast Collagenase with Divalent Cations: Ca2+ Binding by Substrate as a Suggested Recognition Signal for Collagenase Action  Journal Articles
• Interaction of prolyl 4-hydroxylase with synthetic peptide substrates. A conformational model for collagen proline hydroxylation.  Journal Articles
• Mapping Hsp47 binding site(s) using CNBr peptides derived from type I and type II collagen  Journal Articles
• Mapping of Steroids Binding to 17β-Hydroxysteroid Dehydrogenase Type 1 Using Monte Carlo Energy Minimization Reveals Alternative Binding Modes  Journal Articles
• Mapping the Substrate Recognition Landscapes of Metalloproteases Using Comprehensive Mutagenesis  Journal Articles
• Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13  Journal Articles
• Mechanism and Diversity of the Erythromycin Esterase Family of Enzymes  Journal Articles
• Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK  Journal Articles
• Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop  Journal Articles
• Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG)  Journal Articles
• Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome  Journal Articles
• Modification of Pseudomonas aeruginosa Pa5196 Type IV Pilins at Multiple Sites with d -Ara f by a Novel GT-C Family Arabinosyltransferase, TfpW  Journal Articles
• Modulation of a 40-kDa catecholamine regulated protein by dopamine receptor antagonists  Journal Articles
• Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA  Journal Articles
• Mutual Protein-Ligand Conformational Selection Drives cGMP vs. cAMP Selectivity in Protein Kinase G  Journal Articles
• Mycobacterial adenosine kinase is not a typical adenosine kinase  Journal Articles
• Myxoma virus and shope fibroma virus encode dual-specificity tyrosine/serine phosphatases which are essential for virus viability  Journal Articles
• Neuronal Cdc2-like kinase: from cell cycle to neuronal function  Journal Articles
• Neurotensin‐Metabolizing Peptidases in Rat Fundus Plasma Membranes  Journal Articles
• Nickel serves as a substrate recognition motif for the endopeptidase involved in hydrogenase maturation  Journal Articles
• Nitric oxide decreases the excitability of interstitial cells of Cajal through activation of the BK channel  Journal Articles
• Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations  Journal Articles
• Not as fab as we thought  Journal Articles
• Nucleotide Selectivity of Antibiotic Kinases  Journal Articles
• Overexpression and characterization of the chromosomal aminoglycoside 6'-N-acetyltransferase from Enterococcus faecium  Journal Articles
• Overexpression, Purification, and Characterization of VanX, a D-, D-Dipeptidase which Is Essential for Vancomycin Resistance in Enterococcus faecium BM4147  Journal Articles
• Pentavalent Ions Dependency Is a Conserved Property of Adenosine Kinase from Diverse Sources:  Identification of a Novel Motif Implicated in Phosphate and Magnesium Ion Binding and Substrate Inhibition  Journal Articles
• Peptidases in dog-ileum circular and longitudinal smooth-muscle plasma membranes. Their relative contribution to the metabolism of neurotensin  Journal Articles
• Phosphorylated Derivatives That Activate or Inhibit Mammalian Adenosine Kinase Provide Insights into the Role of Pentavalent Ions in AK Catalysis  Journal Articles
• Phosphorylating DNA with DNA  Journal Articles
• Probing ADAMTS13 Substrate Specificity using Phage Display  Journal Articles
• Processing of the Papain Precursor  Journal Articles
• Prodigious substrate specificity of AAC(6′)-APH(2′'), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci  Journal Articles
• Protein engineering reveals ancient adaptive replacements in isocitrate dehydrogenase  Journal Articles
• Purification and properties of Escherichia coli dimethyl sulfoxide reductase, an iron-sulfur molybdoenzyme with broad substrate specificity  Journal Articles
• Purified, Recombinant TagF Protein from Bacillus subtilis 168 Catalyzes the Polymerization of Glycerol Phosphate onto a Membrane Acceptor in Vitro  Journal Articles
• Recent advances on endopeptidase-3.4.24.16  Journal Articles
• Reduction Precedes Cytidylyl Transfer without Substrate Channeling in Distinct Active Sites of the Bifunctional CDP-Ribitol Synthase from Haemophilus influenzae  Journal Articles
• Regiospecificity of Aminoglycoside Phosphotransferase from Enterococci and Staphylococci (APH(3‘)-IIIa)  Journal Articles
• Revitalization of Six Abandoned Catalytic DNA Species Reveals a Common Three-way Junction Framework and Diverse Catalytic Cores  Journal Articles
• Role of the Hydrophobic Segment of Diacylglycerol Kinase ε  Journal Articles
• SANDPUMA: ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across Actinobacteria  Journal Articles
• Selection of novel, specific single-stranded DNA sequences by Flp, a duplex-specific DNA binding protein  Journal Articles
• Selective Cyclooxygenase-2 Inhibitors as Potential Therapeutic Agents for Inflammatory Diseases  Journal Articles
• Selective binding of C-6 OH sulfated hyaluronic acid to the angiogenic isoform of VEGF165  Journal Articles
• Selective depletion of factor XI or factor XII with antisense oligonucleotides attenuates catheter thrombosis in rabbits  Journal Articles
• Simultaneous Inhibition Assay for Human and Microbial Kinases via MALDI‐MS/MS  Journal Articles
• Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor  Journal Articles
• Site‐Selective Affinity Labelling of Maltose Binding Protein in Bacterial Cells  Journal Articles
• Small molecule functional discrimination of the kinases required for the microbial synthesis of threonine and isoleucine  Journal Articles
• Solution Studies of Isepamicin and Conformational Comparisons between Isepamicin and Butirosin A When Bound to an Aminoglycoside 6‘-N-Acetyltransferase Determined by NMR Spectroscopy  Journal Articles
• Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation  Journal Articles
• Some kinetic and toxicological characteristics of thoracic ganglia cholinesterase of Chasmagnathus granulata (Decapoda, Grapsidae)  Journal Articles
• Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues  Journal Articles
• Structural and Functional Plasticity of Antibiotic Resistance Nucleotidylyltransferases Revealed by Molecular Characterization of Lincosamide Nucleotidylyltransferases Lnu(A) and Lnu(D)  Journal Articles
• Structural basis for alginate secretion across the bacterial outer membrane  Journal Articles
• Studies on the Properties and Co-immobilization of Manganese Peroxidase  Conferences
• Substrate Chirality and Specificity of Diacylglycerol Kinases and the Multisubstrate Lipid Kinase  Journal Articles
• Substrate Recognition by a Colistin Resistance Enzyme from Moraxella catarrhalis  Journal Articles
• Target Size of 5′-Nucleotidase in Smooth Muscle1  Journal Articles
• Tau protein binds single‐stranded DNA sequence specifically – the proof obtained in vitro with non‐equilibrium capillary electrophoresis of equilibrium mixtures  Journal Articles
• The Chirality of Phosphatidylserine and the Activation of Protein Kinase C  Journal Articles
• The Double-Stranded RNA-Binding Protein Staufen Is Incorporated in Human Immunodeficiency Virus Type 1: Evidence for a Role in Genomic RNA Encapsidation  Journal Articles
• The Effect of Inorganic Phosphate on the Activity of Bacterial Ribokinase  Journal Articles
• The Influence of Ser-154, Cys-113, and the Phosphorylated Threonine Residue on the Catalytic Reaction Mechanism of Pin1  Journal Articles
• The Pattern of Amino Acid Replacements in α/β-Barrels  Journal Articles
• The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung  Journal Articles
• The cleavage site of restriction endonuclease MnlI  Journal Articles
• The evolution of substrate discrimination in macrolide antibiotic resistance enzymes  Journal Articles
• The modus operandi of a DNA enzyme: enhancement of substrate basicity  Journal Articles
• The molecular basis of the expansive substrate specificity of the antibiotic resistance enzyme aminoglycoside acetyltransferase-6'-aminoglycoside phosphotransferase-2". The role of ASP-99 as an active site base important for acetyl transfer  Journal Articles
• The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor α-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal β-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase  Journal Articles
• Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes  Journal Articles
• Toward a Detailed Understanding of Base Excision Repair Enzymes:  Transition State and Mechanistic Analyses of N-Glycoside Hydrolysis and N-Glycoside Transfer  Journal Articles
• Toward an Efficient DNAzyme  Journal Articles
• Tracing Sequence Diversity Change of RNA-Cleaving Deoxyribozymes under Increasing Selection Pressure during in Vitro Selection  Journal Articles
• Translocational Status of ApoB in the Presence of an Inhibitor of Microsomal Triglyceride Transfer Protein  Journal Articles
• Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast  Journal Articles
• Urokinase has direct catalytic activity against fibrinogen and renders it less clottable by thrombin.  Journal Articles
• Use of CDP-Glycerol as an Alternate Acceptor for the Teichoic Acid Polymerase Reveals that Membrane Association Regulates Polymer Length  Journal Articles
• Vgb from Staphylococcus aureus inactivates streptogramin B antibiotics by an elimination mechanism not hydrolysis  Journal Articles
• YjeQ, an Essential, Conserved, Uncharacterized Protein from Escherichia coli, Is an Unusual GTPase with Circularly Permuted G-Motifs and Marked Burst Kinetics  Journal Articles
• [Boundaries of the butyrylcholinesterase anion site from data of a conformational analysis of substrates].  Journal Articles
• [Determination of productive conformations of acetylcholinesterase substrates using theoretical conformational analysis].  Journal Articles
• [Guanidine derivatives as reversible inhibitors of cholinesterases of various origins: conformation and complex forming].  Journal Articles