Journal article
Selective binding of C-6 OH sulfated hyaluronic acid to the angiogenic isoform of VEGF165
Abstract
Vascular endothelial growth factor 165 (VEGF165) is an important extracellular protein involved in pathological angiogenesis in diseases such as cancer, wet age-related macular degeneration (wet-AMD) and retinitis pigmentosa. VEGF165 exists in two different isoforms: the angiogenic VEGF165a, and the anti-angiogenic VEGF165b. In some angiogenic diseases the proportion of VEGF165b may be equal to or higher than that of VEGF165a. Therefore, …
Authors
Lim D-K; Wylie RG; Langer R; Kohane DS
Journal
Biomaterials, Vol. 77, , pp. 130–138
Publisher
Elsevier
Publication Date
January 2016
DOI
10.1016/j.biomaterials.2015.10.074
ISSN
0142-9612
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceAngiogenesis InhibitorsBevacizumabCarbohydrate ConformationChondroitin SulfatesDrug Evaluation, PreclinicalHuman Umbilical Vein Endothelial CellsHumansHyaluronic AcidKineticsMolecular Sequence DataMolecular WeightNeovascularization, PhysiologicProtein BindingProtein Structure, TertiaryRecombinant ProteinsSubstrate SpecificityVascular Endothelial Growth Factor A