Journal article
Functional differences in the cytochrome P450 1 family enzymes from Zebrafish (Danio rerio) using heterologously expressed proteins
Abstract
Mammalian cytochrome P450 1 (CYP1) genes are well characterized, but in other vertebrates only the functions of CYP1A genes have been well studied. We determined the catalytic activity of zebrafish CYP1A, CYP1B1, CYP1C1, CYP1C2, and CYP1D1 proteins using 11 fluorometric substrates and benzo[a]pyrene (BaP). The resorufin-based substrates, 7-ethoxyresorufin, 7-methoxyresorufin, and 7-benzyloxyresorufin, were well metabolized by all CYP1s except …
Authors
Scornaienchi ML; Thornton C; Willett KL; Wilson JY
Journal
Archives of Biochemistry and Biophysics, Vol. 502, No. 1, pp. 17–22
Publisher
Elsevier
Publication Date
October 2010
DOI
10.1016/j.abb.2010.06.018
ISSN
0003-9861