Journal article
Selective Cyclooxygenase-2 Inhibitors as Potential Therapeutic Agents for Inflammatory Diseases
Abstract
It is now well established that cyclooxygenase exists in two major isoforms, namely cyclooxygnease-1 (Cox-1) and cyclooxygenase-2 (Cox-2). The constitutive isoform, Cox-1, has been well characterized, and the sheep, mouse and human forms have been cloned (DeWitt and Smith, 1988; DeWitt et al., 1990; Yokoyama and Tanabe, 1989). It has been proposed that Cox-1 is involved in the maintenance of prostaglandin-mediated physiological functions, in …
Authors
Chan C-C; Rodger IW
Journal
Advances in Experimental Medicine and Biology, Vol. 407, , pp. 157–161
Publisher
Springer Nature
Publication Date
1997
DOI
10.1007/978-1-4899-1813-0_24
ISSN
0065-2598
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAnti-Inflammatory Agents, Non-SteroidalBone NeoplasmsCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsDinoprostoneDrug Evaluation, PreclinicalHumansIndansIndomethacinInflammationIsoenzymesMembrane ProteinsNeoplasm ProteinsOsteosarcomaProstaglandin-Endoperoxide SynthasesRatsSaimiriStomach UlcerSubstrate Specificity