Journal article
Conformational requirement for lysine hydroxylation in collagen. Structural studies on synthetic peptide substrates of lysyl hydroxylase.
Abstract
An attempt has been made to understand the conformational determinants that govern the hydroxylation of selected lysyl residues in the nascent collagen molecule by lysyl hydroxylase (EC 1.14.11.4). A series of peptide substrates of the enzyme, ranging in length from 3 to 12 residues, were synthesized. These included: tert-butyloxylcarbonyl (t-Boc)-Ile-Lys-Gly; Boc-Ala-Lys-Gly; N-acetyl-Ala-Lys-Gly-Ser; Hyp-Gly-Pro-Lys-Gly-Glu; …
Authors
Jiang P; Ananthanarayanan VS
Journal
Journal of Biological Chemistry, Vol. 266, No. 34, pp. 22960–22967
Publisher
Elsevier
Publication Date
December 1991
DOI
10.1016/s0021-9258(18)54448-3
ISSN
0021-9258