Journal article
Boundaries of the butyrylcholinesterase anion site from data of a conformational analysis of substrates.
Abstract
By means of molecular mechanics, theoretical conformational analysis has been made of 19 substrates of butyrylcholinesterase - acetylcholine derivatives with different structure of the ammonium group. It was concluded that the anionic point is located in the cavity of the enzymic molecule. Dimensions and shape of this cavity were established which provide satisfactory correlation between its filling by substrate conformers and the rate of their …
Authors
Rozengart EV; Zhorov BS
Journal
Zhurnal Evoliutsionnoi Biokhimii I Fiziologii, Vol. 25, No. 2, pp. 189–194
Publication Date
1989
ISSN
0044-4529