Journal article
Simultaneous Inhibition Assay for Human and Microbial Kinases via MALDI‐MS/MS
Abstract
Selective inhibition of one kinase over another is a critical issue in drug development. For antimicrobial development, it is particularly important to selectively inhibit bacterial kinases, which can phosphorylate antimicrobial compounds such as aminoglycosides, without affecting human kinases. Previous work from our group showed the development of a MALDI-MS/MS assay for the detection of small molecule modulators of the bacterial …
Authors
Smith AME; Brennan JD
Journal
ChemBioChem, Vol. 15, No. 4, pp. 587–594
Publisher
Wiley
Publication Date
March 3, 2014
DOI
10.1002/cbic.201300739
ISSN
1439-4227