Mice, SCID Concept

subject area of

• A newly discovered class of human hematopoietic cells with SCID-repopulating activity  Journal Articles
• Acquisition of pluripotency through continued environmental influence on OCT4-induced plastic human fibroblasts  Journal Articles
• Activation of Neural Cell Fate Programs Toward Direct Conversion of Adult Human Fibroblasts into Tri-Potent Neural Progenitors Using OCT-4  Journal Articles
• Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity  Journal Articles
• Adenoviral-Mediated Gene Transfer of Lymphotactin to the Lungs of Mice and Rats Results in Infiltration and Direct Accumulation of CD4⁺, CD8⁺, and NK Cells  Journal Articles
• Adoptive immunotherapy of prostate cancer bone lesions using redirected effector lymphocytes  Journal Articles
• Adoptive transfer of BALb/c mouse splenocytes reduces lesion severity and induces intestinal pathophysiologic changes in the Mycobacterium avium Subspecies paratuberculosis beige/scid mouse model.  Journal Articles
• Adult skin-derived precursor Schwann cells exhibit superior myelination and regeneration supportive properties compared to chronically denervated nerve-derived Schwann cells  Journal Articles
• Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis  Journal Articles
• Amplification of MUC1 in prostate cancer metastasis and CRPC development  Journal Articles
• An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line  Journal Articles
• Analysis of the Human Fetal Liver Hematopoietic Microenvironment  Journal Articles
• Antagonists of the serotonin receptor 5A target human breast tumor initiating cells  Journal Articles
• Anti–protamine-heparin antibodies: incidence, clinical relevance, and pathogenesis  Journal Articles
• Assay of human stem cells by repopulation of NOD/SCID mice  Journal Articles
• Attenuation of the Glucocorticoid Response during Ad5IL-12 Adenovirus Vector Treatment Enhances Natural Killer Cell–Mediated Killing of MHC Class I–Negative LNCaP Prostate Tumors  Journal Articles
• Autoantibodies against the cell surface–associated chaperone GRP78 stimulate tumor growth via tissue factor  Journal Articles
• Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells  Journal Articles
• Bone Morphogenetic Proteins Regulate the Developmental Program of Human Hematopoietic Stem Cells  Journal Articles
• Bone marrow–derived stem cells initiate pancreatic regeneration  Journal Articles
• CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection  Journal Articles
• CD4+ T-Cell Modulation of Visceral Nociception in Mice  Journal Articles
• CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment  Journal Articles
• CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer  Journal Articles
• CYB5D2 displays tumor suppression activities towards cervical cancer  Journal Articles
• Cellular magnetic resonance imaging of monocyte-derived dendritic cell migration from healthy donors and cancer patients as assessed in a scid mouse model  Journal Articles
• Challenges in Cell Fate Acquisition to Scid-Repopulating Activity from Hemogenic Endothelium of hiPSCs Derived from AML Patients Using Forced Transcription Factor Expression  Journal Articles
• Changes in PKM2 Associate with Prostate Cancer Progression  Journal Articles
• Characterization of Mutational Status, Spheroid Formation, and Drug Response of a New Genomically-Stable Human Ovarian Clear Cell Carcinoma Cell Line, 105C  Journal Articles
• Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells  Journal Articles
• Clear cell renal cell carcinoma induces fibroblast-mediated production of stromal periostin  Journal Articles
• Coculture and transplant of purified CD34+Lin− and CD34−Lin− cells reveals functional interaction between repopulating hematopoietic stem cells  Journal Articles
• Common reduction of the Raf kinase inhibitory protein in clear cell renal cell carcinoma  Journal Articles
• Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway  Journal Articles
• Concepts of human leukemic development  Journal Articles
• Contribution of Host-Derived Tissue Factor to Tumor Neovascularization  Journal Articles
• Culture and Isolation of Brain Tumor Initiating Cells  Journal Articles
• Cytokine treatment or accessory cells are required to initiate engraftment of purified primitive human hematopoietic cells transplanted at limiting doses into NOD/SCID mice  Journal Articles
• Defining the roles of perforin, Fas/FasL, and tumour necrosis factor   in T cell induced mucosal damage in the mouse intestine  Journal Articles
• Derivation and Characterization of Hematopoietic Cells From Human Embryonic Stem Cells  Journal Articles
• Derivation of human induced pluripotent stem cells through continued exposure of OCT4-induced plastic human fibroblasts to reprogramming media  Journal Articles
• EGF induces microRNAs that target suppressors of cell migration: miR-15b targets MTSS1 in breast cancer  Journal Articles
• EXPRESSION OF MULTIDRUG RESISTANCE-RELATED PROTEIN (MRP-1), LUNG RESISTANCE-RELATED PROTEIN (LRP) AND TOPOISOMERASE-II (TOPO-II) IN WILMS' TUMOR: IMMUNOHISTOCHEMICAL STUDY USING TMA METHODOLOGY  Journal Articles
• Emergence of muscle and neural hematopoiesis in humans  Journal Articles
• Engineered human Tmpk fused with truncated cell-surface markers: versatile cell-fate control safety cassettes  Journal Articles
• Engraftment of human chronic lymphocytic leukemia cells in SCID mice: in vivo and in vitro studies.  Journal Articles
• Enhanced Protection Against Fatal Mycobacterial Infection in SCID Beige Mice by Reshaping Innate Immunity with IFN-γ Transgene  Journal Articles
• Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments  Journal Articles
• Epigenetic Regulation of SOX9 by the NF-κB Signaling Pathway in Pancreatic Cancer Stem Cells  Journal Articles
• Epigenomic alterations define lethal CIMP-positive ependymomas of infancy  Journal Articles
• Establishment in Severe Combined Immunodeficiency Mice of Subrenal Capsule Xenografts and Transplantable Tumor Lines from a Variety of Primary Human Lung Cancers: Potential Models for Studying Tumor Progression–Related Changes  Journal Articles
• Expression of Dual TCR on DO11.10 T Cells Allows for Ovalbumin-Induced Oral Tolerance to Prevent T Cell-Mediated Colitis Directed against Unrelated Enteric Bacterial Antigens  Journal Articles
• FoxG1 Interacts with Bmi1 to Regulate Self-Renewal and Tumorigenicity of Medulloblastoma Stem Cells  Journal Articles
• Functional analysis of human hematopoietic repopulating cells mobilized with granulocyte colony-stimulating factor alone versus granulocyte colony-stimulating factor in combination with stem cell factor  Journal Articles
• Further evidence for a role of tumor CD200 expression in breast cancer metastasis: decreased metastasis in CD200R1KO mice or using CD200-silenced EMT6  Journal Articles
• GBM secretome induces transient transformation of human neural precursor cells  Journal Articles
• Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopicHOXB4expression  Journal Articles
• Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation  Journal Articles
• Growth inhibition of prostate cancer xenografts by halofuginone*†  Journal Articles
• HSP90 inhibition alters the chemotherapy-driven rearrangement of the oncogenic secretome  Journal Articles
• Hematopoietic capacity of adult human skeletal muscle is negligible  Journal Articles
• Hierarchical and Ontogenic Positions Serve to Define the Molecular Basis of Human Hematopoietic Stem Cell Behavior  Journal Articles
• Human Embryonic Stem Cell-Derived Hematopoietic Cells Maintain Core Epigenetic Machinery of the Polycomb Group/Trithorax Group Complexes Distinctly from Functional Adult Hematopoietic Stem Cells  Journal Articles
• Human embryonic stem cells maintained in the absence of mouse embryonic fibroblasts or conditioned media are capable of hematopoietic development  Journal Articles
• Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells  Journal Articles
• Humanized mice forSalmonellatyphiinfection: new tools for an old problem  Journal Articles
• IQGAP2, A candidate tumour suppressor of prostate tumorigenesis  Journal Articles
• Identification of T-lymphocytic leukemia–initiating stem cells residing in a small subset of patients with acute myeloid leukemic disease  Journal Articles
• Identification of growth factor conditions that reduce ex vivo cord blood progenitor expansion but do not alter human repopulating cell function in vivo.  Journal Articles
• Identification of human brain tumour initiating cells  Journal Articles
• Identification of novel circulating human embryonic blood stem cells  Journal Articles
• Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy  Journal Articles
• Imaging of Fibroblast Activation Protein in Cancer Xenografts Using Novel (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine-Based Small Molecules  Journal Articles
• Immune-mediated neural dysfunction in a murine model of chronic Helicobacter pylori infection  Journal Articles
• Immuno-gene therapy of established prostate tumors using chimeric receptor-redirected human lymphocytes.  Journal Articles
• In Vivo Generation of Neural Tumors from Neoplastic Pluripotent Stem Cells Models Early Human Pediatric Brain Tumor Formation  Journal Articles
• Inability of Human Induced Pluripotent Stem Cell-Hematopoietic Derivatives to Downregulate MicroRNAs In Vivo Reveals a Block in Xenograft Hematopoietic Regeneration  Journal Articles
• Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor  Journal Articles
• Inhibition of the colony-stimulating-factor-1 receptor affects the resistance of lung cancer cells to cisplatin  Journal Articles
• Interferon γ Contributes to Initiation of Uterine Vascular Modification, Decidual Integrity, and Uterine Natural Killer Cell Maturation during Normal Murine Pregnancy  Journal Articles
• Intratumoral administration of an adenovirus expressing a kinase dead form of ErbB-2 inhibits tumor growth  Journal Articles
• Intra–bone marrow transplantation facilitates pauci-clonal human hematopoietic repopulation of NOD/SCID/β2m−/− mice  Journal Articles
• Isolation and characterization of human CD34−Lin− and CD34+Lin− hematopoietic stem cells using cell surface markers AC133 and CD7  Journal Articles
• Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency  Journal Articles
• Kaiso depletion attenuates the growth and survival of triple negative breast cancer cells  Journal Articles
• Lack of MHC expression and retention of ultrastructural characteristics by xenograft transmissible venereal tumor cells in SCID mice  Journal Articles
• Loss of Kaiso expression in breast cancer cells prevents intra-vascular invasion in the lung and secondary metastasis  Journal Articles
• Lymphocyte-mediated regulation of β-endorphin in the myenteric plexus  Journal Articles
• Mannose 6-Phosphate/Insulin-like Growth Factor II Receptor Is a Death Receptor for Granzyme B during Cytotoxic T Cell–Induced Apoptosis  Journal Articles
• Mechanisms of Mucosal and Parenteral Tuberculosis Vaccinations: Adenoviral-Based Mucosal Immunization Preferentially Elicits Sustained Accumulation of Immune Protective CD4 and CD8 T Cells within the Airway Lumen  Journal Articles
• Mesenchymal stem cells ameliorate β cell dysfunction of human type 2 diabetic islets by reversing β cell dedifferentiation  Journal Articles
• Micro-chemical synthesis of molecular probes on an electronic microfluidic device  Journal Articles
• MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia  Journal Articles
• Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13  Journal Articles
• Mucin Gene Deficiency in Mice Impairs Host Resistance to an Enteric Parasitic Infection  Journal Articles
• Mucosal Innate and Adaptive Immune Responses against Herpes Simplex Virus Type 2 in a Humanized Mouse Model  Journal Articles
• Multiple Imprinted and Stemness Genes Provide a Link between Normal and Tumor Progenitor Cells of the Developing Human Kidney  Journal Articles
• Multiple genes in human 20q13 chromosomal region are involved in an advanced prostate cancer xenograft.  Journal Articles
• Multistage nanoparticle delivery system for deep penetration into tumor tissue  Journal Articles
• Neural Cell Adhesion Protein CNTN1 Promotes the Metastatic Progression of Prostate Cancer  Journal Articles
• Noninvasive molecular imaging of apoptosis in vivo using a modified firefly luciferase substrate, Z-DEVD-aminoluciferin  Journal Articles
• Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner  Journal Articles
• Nuclear transportation of exogenous epidermal growth factor receptor and androgen receptor via extracellular vesicles  Journal Articles
• Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis  Journal Articles
• Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition  Journal Articles
• Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection  Journal Articles
• Overexpression of MUC1 and Genomic Alterations in Its Network Associate with Prostate Cancer Progression  Journal Articles
• PI3K Inhibitors Curtail MYC-Dependent Mutant p53 Gain-of-Function in Head and Neck Squamous Cell Carcinoma  Journal Articles
• Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children  Journal Articles
• Propagating factor IX-producing hepatocytes for haemophilia B therapy  Journal Articles
• Prostate cancer stem-like cells proliferate slowly and resist etoposide-induced cytotoxicity via enhancing DNA damage response  Journal Articles
• Protamine (heparin)‐induced thrombocytopenia: a review of the serological and clinical features associated with anti‐protamine/heparin antibodies  Journal Articles
• Protection by CD4 or CD8 T Cells against PulmonaryMycobacterium bovisBacillus Calmette-Guérin Infection  Journal Articles
• Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma  Journal Articles
• Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice  Journal Articles
• Quantitative Analysis Reveals Expansion of Human Hematopoietic Repopulating Cells After Short-term Ex Vivo Culture  Journal Articles
• RNAi screen identifies essential regulators of human brain metastasis-initiating cells  Journal Articles
• Reversible Lineage-Specific Priming of Human Embryonic Stem Cells Can Be Exploited to Optimize the Yield of Differentiated Cells  Journal Articles
• Role of B Cells in Mucosal Vaccine–Induced Protective CD8+ T Cell Immunity against Pulmonary Tuberculosis  Journal Articles
• SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells  Journal Articles
• STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation  Journal Articles
• Smad7 alters cell fate decisions of human hematopoietic repopulating cells  Journal Articles
• Spontaneous Abortion in Immunodeficient SCID Mice  Journal Articles
• Stem cell gene expression programs influence clinical outcome in human leukemia  Journal Articles
• Sulfasalazine‐induced cystine starvation: Potential use for prostate cancer therapy  Journal Articles
• T lymphocyte-dependent and -independent intestinal smooth muscle dysfunction in theT.spiralis-infected mouse  Journal Articles
• TH1/TH2,3 Imbalance due to Cytokine‐Producing NK, γδ T and NK‐γδ T Cells in Murine Pregnancy Decidua in Success or Failure of Pregnancy  Journal Articles
• Targeted Elimination of Prostate Cancer by Genetically Directed Human T Lymphocytes  Journal Articles
• Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer  Journal Articles
• Targeting of CD44 eradicates human acute myeloid leukemic stem cells  Journal Articles
• Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread  Journal Articles
• The Effect of Adding a Surfeit of Autologous CD8⁺T Cells to SCID Mice after Secondary Rexenografts of Graves' Thyroid Tissue  Journal Articles
• The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells  Journal Articles
• The human hematopoietic stem cell compartment is heterogeneous for CXCR4 expression  Journal Articles
• The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity  Journal Articles
• The identification of human pituitary adenoma-initiating cells  Journal Articles
• The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis  Journal Articles
• Therapeutic Potential of Spleen Tyrosine Kinase Inhibition for Treating High-Risk Precursor B Cell Acute Lymphoblastic Leukemia  Journal Articles
• Therapeutic levels of human Factor VIII in mice implanted with encapsulated cells: potential for gene therapy of haemophilia A  Journal Articles
• Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells  Journal Articles
• Transient Gene Transfer of Non-ELR Chemokines to Rodent Lung Induces Mononuclear Cell Accumulation and Activation  Journal Articles
• Treatment of Non-Obese Diabetic (NOD)/Severe-Combined Immunodeficient Mice (SCID) With flt3 Ligand and Interleukin-7 Impairs the B-Lineage Commitment of Repopulating Cells After Transplantation of Human Hematopoietic Cells  Journal Articles
• Ultrasound Imaging of Apoptosis in Tumor Response: Novel Preclinical Monitoring of Photodynamic Therapy Effects  Journal Articles
• Ultrasound Imaging of Apoptosis: Spectroscopic Detection of DNA-Damage Effects In Vivo  Journal Articles
• Undetectable leukemic blasts and absence of NOD/SCID leukemia-initiating cells in cord blood from a case of maternal AML  Journal Articles
• Upregulation of FAM84B during prostate cancer progression  Journal Articles
• Use of a murine xenograft model for canine transmissible venereal tumor  Journal Articles
• WISH-PC2: a unique xenograft model of human prostatic small cell carcinoma.  Journal Articles
• Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cellsinvivo  Journal Articles
• Wnt3a Activates Dormant c-Kit− Bone Marrow-Derived Cells with Short-Term Multilineage Hematopoietic Reconstitution Capacity    Journal Articles
• miR‐10b*, a master inhibitor of the cell cycle, is down‐regulated in human breast tumours  Journal Articles