Journal article
Transcriptional activation of the miR-17-92 cluster is involved in the growth-promoting effects of MYB in human Ph-positive leukemia cells
Abstract
MicroRNAs, non-coding regulators of gene expression, are likely to function as important downstream effectors of many transcription factors including MYB. Optimal levels of MYB are required for transformation/maintenance of BCR-ABL-expressing cells. We investigated whether MYB silencing modulates microRNA expression in Philadelphia-positive (Ph+) leukemia cells and if MYB-regulated microRNAs are important for the "MYB addiction" of these cells. …
Authors
Spagnuolo M; Regazzo G; De Dominici M; Sacconi A; Pelosi A; Korita E; Marchesi F; Pisani F; Magenta A; Lulli V
Journal
Haematologica, Vol. 104, No. 1, pp. 82–92
Publisher
Ferrata Storti Foundation (Haematologica)
Publication Date
January 2019
DOI
10.3324/haematol.2018.191213
ISSN
0390-6078