Anti–protamine-heparin antibodies: incidence, clinical relevance, and pathogenesis Journal Articles

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abstract

Key PointsImmunization against protamine/heparin complexes was frequently observed in patients undergoing cardiac surgery. Platelet-activating anti–protamine-heparin antibodies are a potential risk factor for early postoperative thrombosis and thrombocytopenia.

authors

Bakchoul, Tamam
Zöllner, Heike
Amiral, Jean
Panzer, Simon
Selleng, Sixten
Kohlmann, Thomas
Brandt, Sven
Delcea, Mihaela
Warkentin, Ted
Sachs, Ulrich J
Greinacher, Andreas

status

published

publication date

April 11, 2013

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Aged (MeSH)
Animals (MeSH)
Antibodies (MeSH)
Cardiopulmonary Bypass (MeSH)
Female (MeSH)
Heparin (MeSH)
Heparin Antagonists (MeSH)
Humans (MeSH)
Immunoenzyme Techniques (MeSH)
Immunoglobulin G (MeSH)
Immunology (Science Metrix)
Incidence (MeSH)
Male (MeSH)
Mice (MeSH)
Mice, Inbred NOD (MeSH)
Mice, SCID (MeSH)
Middle Aged (MeSH)
Platelet Count (MeSH)
Platelet Factor 4 (MeSH)
Platelet Transfusion (MeSH)
Protamines (MeSH)
Thrombocytopenia (MeSH)
Time Factors (MeSH)
Transplantation, Heterologous (MeSH)

published in

Blood Journal