Journal article
Lack of MHC expression and retention of ultrastructural characteristics by xenograft transmissible venereal tumor cells in SCID mice
Abstract
Canine transmissible venereal tumor (CTVT) is primarily a tumor of adult dogs with a high incidence of spontaneous regression. We recently reported a xenograft model of CTVT (XTVT) in NOD/SCID mice. XTVT cells retain cytological and histological features of CTVT as well as characteristic rearranged LINE/c-MYC junction [Am. J. Vet. Res. 62 (2001) 907]. In this paper, we demonstrate that XTVT cells maintain ultrastructural characteristics of CTVT …
Authors
Harmelin A; Pinthus JH; Friedmann-Morvinski D; Kaufman K; Brenner O
Journal
Veterinary Immunology and Immunopathology, Vol. 86, No. 3-4, pp. 245–249
Publisher
Elsevier
Publication Date
July 2002
DOI
10.1016/s0165-2427(02)00036-3
ISSN
0165-2427
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsDisease Models, AnimalDog DiseasesDogsFlow CytometryGene Expression Regulation, NeoplasticGenes, MHC Class IGenes, MHC Class IIMajor Histocompatibility ComplexMiceMice, Inbred NODMice, SCIDMicroscopy, ElectronNeoplasm TransplantationSpecific Pathogen-Free OrganismsTransplantation, HeterologousVenereal Tumors, Veterinary