Journal article
Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma
Abstract
We identified a discrete number of microRNAs differentially expressed in benign or malignant mesothelial tissues. We focused on mir-145 whose levels were significantly downregulated in malignant mesothelial tissues and malignant pleural mesothelioma (MPM) cell lines as compared to benign tissues (pleura, peritoneum or cysts). We show that promoter hyper-methylation caused very low levels in MPM cell lines and specimens. Treatment of MPM cell …
Authors
Cioce M; Ganci F; Canu V; Sacconi A; Mori F; Canino C; Korita E; Casini B; Alessandrini G; Cambria A
Journal
Oncogene, Vol. 33, No. 46, pp. 5319–5331
Publisher
Springer Nature
Publication Date
November 13, 2014
DOI
10.1038/onc.2013.476
ISSN
0950-9232
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
3' Untranslated RegionsAnimalsAntineoplastic AgentsBase SequenceCell LineCell Line, TumorCell MovementCell SurvivalCellular SenescenceDNA MethylationDown-RegulationGene Expression ProfilingGene Expression Regulation, NeoplasticGene Knockdown TechniquesGlutamatesGuanineHEK293 CellsHumansLung NeoplasmsMaleMesotheliomaMesothelioma, MalignantMice, SCIDMicroRNAsOctamer Transcription Factor-3PemetrexedPleural NeoplasmsReverse Transcriptase Polymerase Chain ReactionSequence Homology, Nucleic Acid