Journal article
EGF induces microRNAs that target suppressors of cell migration: miR-15b targets MTSS1 in breast cancer
Abstract
Growth factors promote tumor growth and metastasis. We found that epidermal growth factor (EGF) induced a set of 22 microRNAs (miRNAs) before promoting the migration of mammary cells. These miRNAs were more abundant in human breast tumors relative to the surrounding tissue, and their abundance varied among breast cancer subtypes. One of these miRNAs, miR-15b, targeted the 3' untranslated region of MTSS1 (metastasis suppressor protein 1). …
Authors
Kedmi M; Ben-Chetrit N; Körner C; Mancini M; Ben-Moshe NB; Lauriola M; Lavi S; Biagioni F; Carvalho S; Cohen-Dvashi H
Journal
Science Signaling, Vol. 8, No. 368,
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
March 17, 2015
DOI
10.1126/scisignal.2005866
ISSN
1945-0877