Journal article
EXPRESSION OF MULTIDRUG RESISTANCE-RELATED PROTEIN (MRP-1), LUNG RESISTANCE-RELATED PROTEIN (LRP) AND TOPOISOMERASE-II (TOPO-II) IN WILMS’ TUMOR: IMMUNOHISTOCHEMICAL STUDY USING TMA METHODOLOGY
Abstract
AIMS: MRP-1, LRP and TOPO-II are all associated with protection of the cells from the adverse effects of various chemotherapeutics. The aim of this study was to measure the expression of these proteins in Wilms' tumor (WT).
MATERIALS AND METHODS: TMA block was constructed from 14 samples of WT's and from xenografts derived from them. Sections of the TMA were used for immunostaining against MRP-1, LRP and TOPO-IIa.
Authors
Fridman E; Skarda J; Pinthus JH; Ramon J; Mor Y
Journal
Biomedical Papers, Vol. 152, No. 1, pp. 47–51
Publisher
Palacky University Olomouc
Publication Date
June 1, 2008
DOI
10.5507/bp.2008.007
ISSN
1213-8118