Journal article
Contribution of Host-Derived Tissue Factor to Tumor Neovascularization
Abstract
OBJECTIVE: The role of host-derived tissue factor (TF) in tumor growth, angiogenesis, and metastasis has hitherto been unclear and was investigated in this study.
METHODS AND RESULTS: We compared tumor growth, vascularity, and responses to cyclophosphamide (CTX) of tumors in wild-type (wt) mice, or in animals with TF levels reduced by 99% (low-TF mice). Global growth rate of 3 different types of transplantable tumors (LLC, B16F1, and ES …
Authors
Yu J; May L; Milsom C; Anderson GM; Weitz JI; Luyendyk JP; Broze G; Mackman N; Rak J
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 28, No. 11, pp. 1975–1981
Publisher
Wolters Kluwer
Publication Date
November 2008
DOI
10.1161/atvbaha.108.175083
ISSN
1079-5642
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntineoplastic Agents, AlkylatingCarcinoma, Lewis LungCell Line, TumorCell SurvivalCyclophosphamideEmbryonic Stem CellsEndothelial CellsHumansMelanoma, ExperimentalMiceMice, Inbred C57BLMice, SCIDNeoplasm MetastasisNeoplastic Stem CellsNeovascularization, PathologicSecretory VesiclesTeratomaThromboplastinTime Factors