Journal article
Characterization of Mutational Status, Spheroid Formation, and Drug Response of a New Genomically-Stable Human Ovarian Clear Cell Carcinoma Cell Line, 105C
Abstract
Ovarian clear cell carcinoma (OCCC) is a rare subtype of gynecological cancer for which well-characterized and authenticated model systems are scarce. We provide an extensive characterization of '105C', a cell line generated from an adenocarcinoma of the clear cell histotype using targeted next-generation sequencing, cytogenetic microarrays, along with analyses of AKT/mTOR signaling. We report that that the 105C cell line is a bona fide OCCC …
Authors
Kolendowski B; Valdes YR; Hirte H; Itamochi H; Lee W; Carey M; Shepherd TG; DiMattia GE
Journal
Cells, Vol. 9, No. 11,
Publisher
MDPI
DOI
10.3390/cells9112408
ISSN
2073-4409
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAntineoplastic AgentsCell AdhesionCell Line, TumorCell SurvivalChromosomes, HumanDNA Copy Number VariationsDNA Mutational AnalysisDNA-Binding ProteinsFemaleGene Expression Regulation, NeoplasticGenome, HumanGenomic InstabilityHumansMice, Inbred NODMice, SCIDMorpholinesMutationMutation RateOvarian NeoplasmsPhenotypeProto-Oncogene Proteins c-aktSignal TransductionSpheroids, CellularTOR Serine-Threonine KinasesTranscription FactorsXenograft Model Antitumor Assays