Journal article
Mechanisms of Mucosal and Parenteral Tuberculosis Vaccinations: Adenoviral-Based Mucosal Immunization Preferentially Elicits Sustained Accumulation of Immune Protective CD4 and CD8 T Cells within the Airway Lumen
Abstract
The mechanisms underlying better immune protection by mucosal vaccination have remained poorly understood. In our current study we have investigated the mechanisms by which respiratory virus-mediated mucosal vaccination provides remarkably better immune protection against pulmonary tuberculosis than parenteral vaccination. A recombinant adenovirus-based tuberculosis (TB) vaccine expressing Mycobacterium tuberculosis Ag85A (AdAg85A) was …
Authors
Santosuosso M; Zhang X; McCormick S; Wang J; Hitt M; Xing Z
Journal
The Journal of Immunology, Vol. 174, No. 12, pp. 7986–7994
Publisher
Oxford University Press (OUP)
Publication Date
June 15, 2005
DOI
10.4049/jimmunol.174.12.7986
ISSN
0022-1767
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AcyltransferasesAdenoviridaeAdministration, IntranasalAdoptive TransferAnimalsAntigens, BacterialBronchiCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell MovementCytotoxicity Tests, ImmunologicFemaleImmunization, SecondaryInjections, IntramuscularLungLymphocyte CountMiceMice, Inbred BALB CMice, SCIDRespiratory MucosaSpleenTuberculosisTuberculosis VaccinesVaccines, Synthetic