Journal article
Multistage nanoparticle delivery system for deep penetration into tumor tissue
Abstract
Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided only modest survival benefits. This suboptimal outcome is likely due to physiological barriers that hinder delivery of the nanotherapeutics throughout the tumor. Many of these nanotherapeutics are ≈ 100 nm in diameter and …
Authors
Wong C; Stylianopoulos T; Cui J; Martin J; Chauhan VP; Jiang W; Popović Z; Jain RK; Bawendi MG; Fukumura D
Journal
Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 6, pp. 2426–2431
Publisher
Proceedings of the National Academy of Sciences
Publication Date
February 8, 2011
DOI
10.1073/pnas.1018382108
ISSN
0027-8424