Journal article
SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells
Abstract
SOX2 is an essential transcription factor for stem cells and plays a role in tumorigenesis, however its role in prostate cancer stem cells (PCSCs) remains unclear. We report here a significant upregulation of SOX2 at both mRNA and protein levels in DU145 PCSCs propagated as suspension spheres in vitro. The expression of SOX2 in DU145 PCSCs is positively regulated by epidermal growth factor receptor (EGFR) signaling. Activation of EGFR …
Authors
Rybak AP; Tang D
Journal
Cellular Signalling, Vol. 25, No. 12, pp. 2734–2742
Publisher
Elsevier
Publication Date
December 2013
DOI
10.1016/j.cellsig.2013.08.041
ISSN
0898-6568