Journal article
Transient Gene Transfer of Non-ELR Chemokines to Rodent Lung Induces Mononuclear Cell Accumulation and Activation
Abstract
The in vivo function of the CXC chemokines interferon-inducible protein-10 (IP-10) and monokine induced by gamma (MIG) was examined using replication-deficient adenoviral vectors expressing human IP-10 (AdIP-10) or murine MIG (AdMIG). Intratracheal and intranasal administration of AdIP-10 or AdMIG into rats and mice produced transient chemokine overexpression from the bronchial epithelium. IP-10 concentrations in the bronchoalveolar lavage …
Authors
Palmer K; Emtage PC; Strieter RM; Gauldie J
Journal
Journal of Interferon & Cytokine Research, Vol. 19, No. 12, pp. 1381–1390
Publisher
Mary Ann Liebert
Publication Date
December 1999
DOI
10.1089/107999099312849
ISSN
1079-9907
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAnimalsBase SequenceBronchoalveolar Lavage FluidChemokine CXCL10Chemokine CXCL9Chemokines, CXCCloning, MolecularDNA PrimersFemaleGene ExpressionGene Transfer TechniquesGenetic VectorsHumansIntercellular Signaling Peptides and ProteinsInterferon-gammaInterleukin-4Leukocytes, MononuclearLungLymphocyte ActivationMaleMiceMice, Inbred BALB CMice, SCIDRatsRats, Sprague-Dawley