Journal article
CD4+ T-Cell Modulation of Visceral Nociception in Mice
Abstract
BACKGROUND & AIMS: Although inflammatory and immune cells are present in the gut in the absence of pathology, their presence does not result in sensitization of sensory nerves, implying the existence of a local antinociceptive influence. We hypothesized that a component of the immune system exerts an antinociceptive influence, thus enabling the gut to function in the absence of undue pain or discomfort.
METHODS: Visceromotor responses to …
Authors
Verma–Gandhu M; Bercik P; Motomura Y; Verdu EF; Khan WI; Blennerhassett PA; Wang L; El–Sharkawy RT; Collins SM
Journal
Gastroenterology, Vol. 130, No. 6, pp. 1721–1728
Publisher
Elsevier
Publication Date
May 2006
DOI
10.1053/j.gastro.2006.01.045
ISSN
0016-5085