Journal article
Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells
Abstract
PurposeGlioblastoma (GBM) is the most aggressive adult brain cancer, with a 15 month median survivorship attributed to the existence of treatment-refractory brain tumor initiating cells (BTICs). In order to better understand the mechanisms regulating the tumorigenic properties of this population, we studied the role of the polycomb group member BMI1 in our patient-derived GBM BTICs and its relationship with CD133, a well-established marker of …
Authors
Vora P; Seyfrid M; Venugopal C; Qazi MA; Salim S; Isserlin R; Subapanditha M; O’Farrell E; Mahendram S; Singh M
Journal
Journal of Neuro-Oncology, Vol. 143, No. 3, pp. 417–428
Publisher
Springer Nature
Publication Date
July 2019
DOI
10.1007/s11060-019-03192-1
ISSN
0167-594X