Leukemia, Myeloid, Acute Concept

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• In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target  Journal Articles
• A Review of Pneumatosis Intestinalis in the Setting of Systemic Cancer Treatments, Including Tyrosine Kinase Inhibitors  Journal Articles
• A phase 1 trial evaluating thioridazine in combination with cytarabine in patients with acute myeloid leukemia  Journal Articles
• A phase I study of tipifarnib combined with conventional induction and consolidation therapy for previously untreated patients with acute myeloid leukemia aged 60 years and over  Journal Articles
• A phase I trial of two sequence-specific schedules of decitabine and vorinostat in patients with acute myeloid leukemia  Journal Articles
• A phase I/II study of sorafenib in combination with low dose cytarabine in elderly patients with acute myeloid leukemia or high-risk myelodysplastic syndrome from the National Cancer Institute of Canada Clinical Trials Group: trial IND.186  Journal Articles
• A pilot study of carboplatin augmentation therapy for patients with poor risk acute non-lymphocytic leukemia  Journal Articles
• A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopenia  Journal Articles
• ATIR101 administered after T-cell-depleted haploidentical HSCT reduces NRM and improves overall survival in acute leukemia  Journal Articles
• Abnormal dopamine receptor signaling allows selective therapeutic targeting of neoplastic progenitors in AML patients  Journal Articles
• Acute myelogenous leukemia in adolescents and young adults  Journal Articles
• Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche  Journal Articles
• Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity  Journal Articles
• American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults  Journal Articles
• An Increase in Cellular Size Variance Contributes to the Increase in Ultrasound Backscatter During Cell Death  Journal Articles
• Analysis of the recent cluster of invasive fungal sinusitis at the Toronto Hospital for Sick Children.  Journal Articles
• Anthracyclines during induction therapy in acute myeloid leukaemia: a systematic review and meta‐analysis  Journal Articles
• Assessment of the downstream portion of the mitochondrial pathway of caspase activation in patients with acute myeloid leukemia  Journal Articles
• Association Between Corticosteroids and Infection, Sepsis, and Infectious Death in Pediatric Acute Myeloid Leukemia (AML): Results From the Canadian Infections in AML Research Group  Journal Articles
• Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia  Journal Articles
• Azacitidine and its role in the upfront treatment of acute myeloid leukemia  Journal Articles
• Brief Report: Human Acute Myeloid Leukemia Reprogramming to Pluripotency Is a Rare Event and Selects for Patient Hematopoietic Cells Devoid of Leukemic Mutations  Journal Articles
• Canadian multicenter pilot trial of haploidentical donor transplantation  Journal Articles
• Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex  Journal Articles
• Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient-Specific Genomic Aberrations  Journal Articles
• Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure  Journal Articles
• Challenges in Cell Fate Acquisition to Scid-Repopulating Activity from Hemogenic Endothelium of hiPSCs Derived from AML Patients Using Forced Transcription Factor Expression  Journal Articles
• Classifying acute leukemia by immunophenotyping: a combined FAB- immunologic classification of AML  Journal Articles
• Clinical Characteristics and Treatment Outcomes of Testicular Myeloid Sarcomas After Hematopoietic Stem Cell Transplantation: A Single-institution Experience  Journal Articles
• Clinical and biological implications of driver mutations in myelodysplastic syndromes  Journal Articles
• Clinical benefit of glasdegib plus low-dose cytarabine in patients with de novo and secondary acute myeloid leukemia: long-term analysis of a phase II randomized trial  Journal Articles
• Clinical manifestations associated with the aberrant expression of the soluble granulocyte–macrophage colony‐stimulating factor receptor in patients presenting with haematological malignancies  Journal Articles
• Clostridium difficile Infection in Pediatric Acute Myeloid Leukemia  Journal Articles
• Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells  Journal Articles
• Consolidation Therapy With Autologous Bone Marrow Transplantation in Adults With Acute Myeloid Leukemia: A Meta-analysis  Journal Articles
• Diminished AHR Signaling Drives Human Acute Myeloid Leukemia Stem Cell Maintenance  Journal Articles
• Duration of first remission and hematopoietic cell transplantation-specific comorbidity index but not age predict survival of patients with AML transplanted in CR2: a retrospective multicenter study  Journal Articles
• Early Life Nutrition Factors and Risk of Acute Leukemia in Children: Systematic Review and Meta-Analysis  Journal Articles
• Early Mixed Donor Chimerism is a Strong Negative Prognostic Indicator in Allogeneic Stem Cell Transplant for AML and MDS.  Journal Articles
• Economic evaluation of allogeneic bone marrow transplantation: a rudimentary model to generate estimates for the timely formulation of clinical policy.  Journal Articles
• Epigenetic maintenance strategies after allogeneic stem cell transplantation in acute myeloid leukemia  Journal Articles
• Epigenetic regulation of noncanonical menin targets modulates menin inhibitor response in acute myeloid leukemia.  Journal Articles
• Estrogen Receptor β Is a Novel Target in Acute Myeloid Leukemia  Journal Articles
• Evaluating the Economic Burden of Acute Myeloid Leukemia in Canada  Conferences
• Evidence-based support for phenotypic drug discovery in acute myeloid leukemia  Journal Articles
• Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus  Journal Articles
• Factors and inhibitors of blood coagulation and fibrinolysis in acute nonlymphoblastic leukaemia  Journal Articles
• Functional role of BAALC in leukemogenesis  Journal Articles
• GFI1 is required for RUNX1/ETO positive acute myeloid leukemia  Journal Articles
• GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia  Journal Articles
• Glutamine Metabolism Mediates Sensitivity to Respiratory Complex II Inhibition in Acute Myeloid Leukemia  Journal Articles
• Hematopoietic colony-stimulating factor priming does not influence survival in acute myeloid leukemia: a meta-analysis of randomized trials  Journal Articles
• Hemoglobin abnormalities in neoplastic hematological disorders.  Journal Articles
• Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia  Journal Articles
• Human acute myeloid leukemia stem cells  Journal Articles
• Humanized zebrafish enhance human hematopoietic stem cell survival and promote acute myeloid leukemia clonal diversity  Journal Articles
• Humanized zebrafish enhance human hematopoietic stem cell survival and promote acute myeloid leukemia clonal diversity.  Journal Articles
• Hypoxia factors suffocate leukemic stem cell initiation  Journal Articles
• Identification of Chemotherapy-Induced Leukemic-Regenerating Cells Reveals a Transient Vulnerability of Human AML Recurrence  Journal Articles
• Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells  Journal Articles
• Identification of T-lymphocytic leukemia–initiating stem cells residing in a small subset of patients with acute myeloid leukemic disease  Journal Articles
• Identification of cells of leukemic stem cell origin with non-canonical regenerative properties  Journal Articles
• Impact of intensity of conditioning therapy in patients aged 40–60 years with AML/myelodysplastic syndrome undergoing allogeneic transplantation  Journal Articles
• Impact of registration on clinical trials on infection risk in pediatric acute myeloid leukemia  Journal Articles
• Implementation of a Routine Screening Program for Latent Tuberculosis Infection among Patients with Acute Leukemia at a Canadian Cancer Center  Journal Articles
• Importance of Nutrition in the Treatment of Leukemia in Children and Adolescents  Journal Articles
• In-depth characterization of the microRNA transcriptome in a leukemia progression model.  Journal Articles
• Incidence and predictors of treatment-related mortality in paediatric acute leukaemia in El Salvador  Journal Articles
• Infections in pediatric acute promyelocytic leukemia: from the canadian infections in acute myeloid leukemia research group  Journal Articles
• Infectious Events Prior to Chemotherapy Initiation in Children with Acute Myeloid Leukemia  Journal Articles
• Inferior outcomes for overweight children undergoing allogeneic stem cell transplantation  Journal Articles
• Intensive versus less-intensive antileukemic therapy in older adults with acute myeloid leukemia: A systematic review  Journal Articles
• Invasive fungal infections in paediatric acute myeloid leukaemia  Journal Articles
• LSD1 inhibition by tranylcypromine derivatives interferes with GFI1-mediated repression of PU.1 target genes and induces differentiation in AML  Journal Articles
• Less intensive antileukemic therapies (monotherapy and/or combination) for older adults with acute myeloid leukemia who are not candidates for intensive antileukemic therapy: A systematic review and meta-analysis  Journal Articles
• Leukapheresis and low-dose chemotherapy do not reduce early mortality in acute myeloid leukemia hyperleukocytosis: A systematic review and meta-analysis  Journal Articles
• Leukemia targeting ligands isolated from phage display peptide libraries  Journal Articles
• Leukemic progenitor compartment serves as a prognostic measure of cancer stemness in patients with acute myeloid leukemia  Journal Articles
• Long-term outcomes to fludarabine and rituximab in Waldenström macroglobulinemia  Journal Articles
• Long‐term follow‐up of VIALE‐A: Venetoclax and azacitidine in chemotherapy‐ineligible untreated acute myeloid leukemia  Journal Articles
• Loss of DEP-1 (Ptprj) promotes myeloproliferative disease in FLT3-ITD acute myeloid leukemia  Journal Articles
• Management of hemostatic complications in acute leukemia: Guidance from the SSC of the ISTH  Journal Articles
• Methodological rigor lacking in an analysis of acute myeloid leukemia incidence and geographic distribution in Canada  Journal Articles
• MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia  Journal Articles
• Mismatched unrelated hematopoietic stem cell transplantation with post-transplant cyclophosphamide for high-risk acute myeloid leukemia  Journal Articles
• Mixed acute leukaemias  Journal Articles
• Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13  Journal Articles
• Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin  Journal Articles
• NOX4-driven ROS formation mediates PTP inactivation and cell transformation in FLT3ITD-positive AML cells  Journal Articles
• Nephrotoxicity Associated with Combined Gentamicin – Amphotericin B Therapy  Journal Articles
• Neuropsychological late effects of treatment for acute leukemia in children with Down syndrome  Journal Articles
• Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs  Journal Articles
• Nonhematopoietic cells represent a more rational target of in vivo hedgehog signaling affecting normal or acute myeloid leukemia progenitors  Journal Articles
• Nutrition of Children With Cancer in Brazil: A Systematic Review  Journal Articles
• One-Year Survival and Prognosticators of Adults With Acute Leukemia at the Uganda Cancer Institute  Journal Articles
• Outcome of patients who develop acute leukemia or myelodysplasia as a second malignancy after solid tumors treated surgically or with strategies that include chemotherapy and/or radiation  Journal Articles
• PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia  Journal Articles
• Pharmacokinetics and safety results from the Phase 3 randomized, open-label, study of intravenous posaconazole in patients at risk of invasive fungal disease  Journal Articles
• Phase II study of targeted therapy with temozolomide in acute myeloid leukaemia and high‐risk myelodysplastic syndrome patients pre‐screened for low O⁶‐methylguanine DNA methyltransferase expression  Journal Articles
• Phase I/II study of the deacetylase inhibitor panobinostat after allogeneic stem cell transplantation in patients with high-risk MDS or AML (PANOBEST trial)  Journal Articles
• Phosphorylation state of the histone variant H2A.X controls human stem and progenitor cell fate decisions  Journal Articles
• Polo-like kinases in AML  Journal Articles
• Preclinical characterization and clinical trial of CFI-400945, a polo-like kinase 4 inhibitor, in patients with relapsed/refractory acute myeloid leukemia and higher-risk myelodysplastic neoplasms  Journal Articles
• Predictors and Outcomes of Viridans Group Streptococcal Infections in Pediatric Acute Myeloid Leukemia  Journal Articles
• Prognosis of older patients with newly diagnosed AML undergoing antileukemic therapy: A systematic review  Journal Articles
• Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening  Journal Articles
• Quality of life and physical function in adults treated with intensive chemotherapy for acute myeloid leukemia improve over time independent of age  Journal Articles
• Quizartinib for the treatment of acute myeloid leukemia  Journal Articles
• RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity  Journal Articles
• Randomized Trials in Oncology Stopped Early for Benefit  Journal Articles
• Re: Consolidation Therapy With Autologous Bone Marrow Transplantation in Adults With Acute Myeloid Leukemia: A Meta-analysis  Journal Articles
• Real-World Treatment Patterns and Clinical Outcomes in Canadian Patients with AML Unfit for First-Line Intensive Chemotherapy  Journal Articles
• Real-world treatment patterns and outcomes with oral azacitidine maintenance therapy in patients with acute myeloid leukemia.  Journal Articles
• Regulation of the adaptor molecule LAT2, an in vivo target gene of AML1/ETO (RUNX1/RUNX1T1), during myeloid differentiation  Journal Articles
• Relation between platinum-DNA adducts and complete remission in adult acute nonlymphocytic leukemia  Journal Articles
• Reprogramming of Acute Myeloid Leukemia Patients Cells: Harboring Cancer Mutations Requires Targeting of AML Hierarchy  Journal Articles
• Role of Maternal Diet in the Risk of Childhood Acute Leukemia: A Systematic Review and Meta-Analysis  Journal Articles
• Sam68 Allows Selective Targeting of Human Cancer Stem Cells  Journal Articles
• Selection and management of older patients with acute myeloid leukemia treated with glasdegib plus low-dose cytarabine: expert panel review  Journal Articles
• Simultaneous or sequential expression of lymphoid and myeloid phenotypes in acute leukemia  Journal Articles
• Single nucleotide polymorphism in IL1B is associated with infection risk in paediatric acute myeloid leukaemia  Journal Articles
• Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells  Journal Articles
• Sodium butyrate and a T lymphocyte cell line-derived differentiation factor induce basophilic differentiation of the human promyelocytic leukemia cell line HL-60  Journal Articles
• Sorafenib Maintenance After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With FLT3–Internal Tandem Duplication Mutation (SORMAIN)  Journal Articles
• Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models.  Journal Articles
• Spurious detection of terminal deoxynucleotidyl transferase in phytohemagglutinin-stimulated lymphocytes  Journal Articles
• Stem cell gene expression programs influence clinical outcome in human leukemia  Journal Articles
• Survival outcomes and clinical benefit in patients with acute myeloid leukemia treated with glasdegib and low-dose cytarabine according to response to therapy  Journal Articles
• Systemic infection by Rhodotorula spp. in the immunocompromised host  Journal Articles
• T cell surface antigens in blast crisis of CML [letter]  Journal Articles
• Targeting SUMOylation dependency in human cancer stem cells through a unique SAE2 motif revealed by chemical genomics  Journal Articles
• Targeting of CD44 eradicates human acute myeloid leukemic stem cells  Journal Articles
• Testicular Myeloid Sarcoma  Journal Articles
• The Patterns of Fetal Haemoglobin Production in Leukaemia  Journal Articles
• The Role of the Plasma from Platelet Concentrates in Transfusion Reactions  Journal Articles
• The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells  Journal Articles
• The impact of category, cytopathology and cytogenetics on development and progression of clonal and malignant myeloid transformation in inherited bone marrow failure syndromes  Journal Articles
• The low incidence of secondary acute myelogenous leukaemia in children and adolescents treated with dexrazoxane for acute lymphoblastic leukaemia: A report from the Dana-Farber Cancer Institute ALL Consortium  Journal Articles
• The risk of bleeding in thrombocytopenic patients with acute myeloid leukemia.  Journal Articles
• The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation  Journal Articles
• The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors  Journal Articles
• The treatment of acute myelocytic leukemia in patients 30 years of age and younger  Journal Articles
• Therapy-related leukemia associated with high-dose 4-epi-doxorubicin and cyclophosphamide used as adjuvant chemotherapy for breast cancer.  Journal Articles
• Transfusion-related Iron Overload in Children With Leukemia  Conferences
• Translocation (14;19) in acute biphenotypic leukemia  Journal Articles
• Treatment outcomes for newly diagnosed, treatment-naïve TP53-mutated acute myeloid leukemia: a systematic review and meta-analysis  Journal Articles
• Ultrasound Imaging of DNA-Damage Effects in Live Cultured Cells and in Brain Tissue  Journal Articles
• Undetectable leukemic blasts and absence of NOD/SCID leukemia-initiating cells in cord blood from a case of maternal AML  Journal Articles
• Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove  Journal Articles
• Use of the day 6 bone marrow to alter remission induction therapy in patients with acute myeloid leukaemia: a leukemia intergroup study  Journal Articles
• Very long chain fatty acid metabolism is required in acute myeloid leukemia  Journal Articles
• Vorinostat induces reactive oxygen species and DNA damage in acute myeloid leukemia cells.  Journal Articles
• WTAP and m6A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells  Journal Articles
• XXIII International Association for Comparative Research on Leukemia and Related Diseases Symposium: from Molecular Pathogenesis to Targeted Therapy in Leukemia and Solid Tumors  Conferences
• β2 integrin–derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis  Journal Articles