Journal article
Glutamine Metabolism Mediates Sensitivity to Respiratory Complex II Inhibition in Acute Myeloid Leukemia.
Abstract
Acute myeloid leukemia (AML) is a hematologic malignancy metabolically dependent on oxidative phosphorylation and mitochondrial electron transport chain (ETC) activity. AML cells are distinct from their normal hematopoietic counterparts by this metabolic reprogramming, which presents targets for new selective therapies. Here, metabolic changes in AML cells after ETC impairment are investigated. Genetic knockdown of the ETC complex II (CII) …
Authors
Roma A; Tcheng M; Ahmed N; Walker S; Jayanth P; Minden MD; Hope K; Nekkar Rao PP; Luc J; Doxey AC
Journal
Molecular Cancer Research, Vol. 20, No. 11, pp. 1659–1673
Publisher
American Association for Cancer Research (AACR)
Publication Date
November 3, 2022
DOI
10.1158/1541-7786.mcr-21-1032
ISSN
1541-7786