Journal article
β2 integrin–derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis
Abstract
Spleen tyrosine kinase (Syk) induces cell survival and proliferation in a high proportion of acute myeloid leukemia (AML) blasts, but the underlying molecular events of Syk signaling have not been investigated. Proteomic techniques have allowed us to identify the multiprotein complex that is nucleated by constitutively active Syk in AML cells. This complex differs from the B-lymphoid Syk interactome with respect to several proteins, especially …
Authors
Oellerich T; Oellerich MF; Engelke M; Münch S; Mohr S; Nimz M; Hsiao H-H; Corso J; Zhang J; Bohnenberger H
Journal
Blood, Vol. 121, No. 19, pp. 3889–3899
Publisher
American Society of Hematology
Publication Date
May 9, 2013
DOI
10.1182/blood-2012-09-457887
ISSN
0006-4971
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Amino Acid SequenceCD18 AntigensCell ProliferationCell SurvivalHumansIntracellular Signaling Peptides and ProteinsLeukemia, Myeloid, AcuteModels, BiologicalMolecular Sequence DataProtein Kinase InhibitorsProtein-Tyrosine KinasesSTAT Transcription FactorsSTAT3 Transcription FactorSTAT5 Transcription FactorSignal TransductionSyk KinaseTumor Cells, Cultured