β2 integrin–derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis Journal Articles

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abstract

Key PointsIntegrin signaling promotes proliferative signals in AML cells that are mediated by the kinase Syk and the transcription factors STAT3 and STAT5.

authors

Oellerich, Thomas
Oellerich, Mark F
Engelke, Michael
Münch, Silvia
Mohr, Sebastian
Nimz, Marika
Hsiao, He-Hsuan
Corso, Jasmin
Zhang, Jing
Bohnenberger, Hanibal
Berg, Tobias
Rieger, Michael A
Wienands, Jürgen
Bug, Gesine
Brandts, Christian
Urlaub, Henning
Serve, Hubert

status

published

publication date

May 9, 2013

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Amino Acid Sequence (MeSH)
CD18 Antigens (MeSH)
Cell Proliferation (MeSH)
Cell Survival (MeSH)
Humans (MeSH)
Immunology (Science Metrix)
Intracellular Signaling Peptides and Proteins (MeSH)
Leukemia, Myeloid, Acute (MeSH)
Models, Biological (MeSH)
Molecular Sequence Data (MeSH)
Protein Kinase Inhibitors (MeSH)
Protein-Tyrosine Kinases (MeSH)
STAT Transcription Factors (MeSH)
STAT3 Transcription Factor (MeSH)
STAT5 Transcription Factor (MeSH)
Signal Transduction (MeSH)
Syk Kinase (MeSH)
Tumor Cells, Cultured (MeSH)

published in

Blood Journal