Journal article
Leukemic progenitor compartment serves as a prognostic measure of cancer stemness in patients with acute myeloid leukemia
Abstract
We systematically investigate functional and molecular measures of stemness in patients with acute myeloid leukemia (AML) using a cohort of 121 individuals. We confirm that the presence of leukemic stem cells (LSCs) detected through in vivo xenograft transplantation is associated with poor survival. However, the measurement of leukemic progenitor cells (LPCs) through in vitro colony-forming assays provides an even stronger predictor of overall …
Authors
Boyd AL; Lu J; Hollands CG; Alsostovar L; Murali S; Reid JC; Ye W; Vandersluis S; Johnson P; ElRafie A
Journal
Cell Reports Medicine, Vol. 4, No. 7,
Publisher
Elsevier
Publication Date
July 2023
DOI
10.1016/j.xcrm.2023.101108
ISSN
2666-3791