Clinical and biological implications of driver mutations in myelodysplastic syndromes Journal Articles

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abstract

Key Points MDS is characterized by mutations in >40 genes, a complex structure of gene-gene interactions and extensive subclonal diversification. The total number of oncogenic mutations and early detection of subclonal mutations are significant prognostic variables in MDS.

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status

published

publication date

November 21, 2013

has subject area

1102 Cardiorespiratory Medicine and Haematology (FoR)
1103 Clinical Sciences (FoR)
1114 Paediatrics and Reproductive Medicine (FoR)
Aged (MeSH)
Aged, 80 and over (MeSH)
Cohort Studies (MeSH)
Disease Progression (MeSH)
Epistasis, Genetic (MeSH)
Female (MeSH)
Humans (MeSH)
Immunology (Science Metrix)
Leukemia, Myeloid, Acute (MeSH)
Leukemia, Myelomonocytic, Chronic (MeSH)
Male (MeSH)
Middle Aged (MeSH)
Mutation (MeSH)
Myelodysplastic Syndromes (MeSH)
Myelodysplastic-Myeloproliferative Diseases (MeSH)
Oncogenes (MeSH)
Prognosis (MeSH)
RNA Splicing (MeSH)
Spliceosomes (MeSH)

published in

Blood Journal